| Project/Area Number |
21592289
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
UENO Masaki 香川大学, 医学部, 準教授
HAMAMOTO Yhusuke 香川大学, 医学部, 助教
KOGURE Tetukuni 香川大学, 医学部, 助教
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 多血小板血漿 / FGF-2 / 細胞増殖因子 / 細胞外マトリックス / 再生組織 / 多血漿板血漿 / FGF / 再生医療 / 血管付き軟組織 / tissue engineering chamber / 骨髄液由来多血小板血漿 / 線維芽細胞増殖因子 |
|---|
| Research Abstract |
We evaluated a method to regenerate soft tissue flap in a tissue engineering chamber(TEC) as a site of regeneration by concomitantly using an AV bundle, artificial dermis, FGF-2, and platelet-rich plasma(PRP). The samples were divided into control, FGF-2, non-activated PRP, activated PRP, non-activated PRP+ FGF-2, and activated PRP+ FGF-2 groups, and the amount of regenerated tissue, degree of maturation of organization were evaluated. Results : Non-activated PRP induced more satisfactory regeneration of vascularized soft tissue than Activated PRP. Regenerated tissue with the highest degree of maturation was obtained in the non-activated PRP+ FGF-2group. The results indicate that the simultaneous use of non-activated PRP and FGF-2 is advantageous for the regeneration of vascularized soft tissue in a TEC.
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