Bach1 mRNA expression is a novel marker of heme-mediated oxidative liver injury.
| Project/Area Number |
21592307
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORITA Kiyoshi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (40108171)
TAKAHASHI Toru 岡山大学, 岡山大学病院, 准教授 (40252952)
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| Research Collaborator |
OHMORI Emiko 岡山大学, 大学院・医歯薬学総合研究科, 技術補佐員
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 集中治療学 / 急性肝不全 / 酸化ストレス / ヘム / Bach1 / ヘムオキシゲナーゼ / チトクロームp450 / 四塩化炭素 / ヘムオキシゲナーゼ1(HO-1) / ヘムオキシゲナーゼ-1(HO-1) / 非特異型デルタアミノレブリン酸合成酵素(ALAS1) |
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| Research Abstract |
Bach1 is a heme-responsive transcription factor that represses ho-1 gene expression. In the present study, a transient and dramatic induction of Bach1 was caused by heme-mediated oxidative stress in carbon tetrachloride(CCl4)-induced acute liver failure in rats. These findings suggest that Bach1 mRNA is increased by heme-mediated oxidative stress and that it may be a marker of heme-mediated oxidative stress.
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Report
(4 results)
Research Products
(20 results)
