Analysis of molecular mechanism of hypophosphatasia
| Project/Area Number |
21592355
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SOHDA Miwa 新潟大学, 医歯学系, 助教 (20258528)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 遺伝子疾患 / 発症メカニズム / 突然変異 / 石灰化不全 / 骨代謝異常 / 石灰化 / 骨と歯 / アルカリフォスファターゼ / 発症の分子基盤 / アルカリホスファターゼ / 先天性 / 代謝異常 |
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| Research Abstract |
Hypophosphatasia(HPP), an inborn error of metabolism, is caused by various loss-in-function mutations in the tissue-nonspecific alkaline phosphatase gene. However, little has been known as to how these mutations lead to development of HPP. In this study we have examined two missense mutations related with disulfide bond linkage and one mutation involved in dominantly transmitted HPP at the molecular level.
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Report
(4 results)
Research Products
(62 results)
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[Journal Article] Morphological assessment of bone mineralization in tibial metaphyses of ascorbic acid-deficient ODS rats2011
Author(s)
Hasegawa T, Li M, Hara K, Sasaki M, Tabata C, de Freitas PH, Hongo H, Suzuki R, Kobayashi M, Inoue K, Yamamoto T, Oohata N, Oda K, Akiyama Y, Amizuka N
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Journal Title
Biomed Res
Volume: 32
Pages: 259-69
NAID
Related Report
Peer Reviewed
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[Journal Article] Eldecalcitol, a second-generation vitamin D analog, drives bone minimodeling and reduces osteoclastic number in trabecular bone of ovariectomized rats2011
Author(s)
de Freitas PH, Hasegawa T, Takeda S, Sasaki M, Tabata C, Oda K, Li M, Saito H, Amizuka N.
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Journal Title
Bone
Volume: 49
Pages: 335-42
Related Report
Peer Reviewed
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[Journal Article] Tissue nonspecific alkaline phosphatase is activated via a two-step mechanism by zinc transport complexes in the early secretory pathway2011
Author(s)
Fukunaka A, Kurokawa Y, Teranishi F, Sekler I, Oda K, Ackland ML, Faundez V, Hiromura M, Masuda S, Nagao M, Enomoto S, Kambe T
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Journal Title
J Biol Chem
Volume: 286
Pages: 16363-73
Related Report
Peer Reviewed
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[Journal Article] Ultrastructural observation on cells meeting the histological criteria for preosteoblasts-a study in the mouse tibial metaphysis2010
Author(s)
Narimatsu K, Li M, de Freitas PH, Sultana S, Ubaidus S, Kojima T, Zhucheng L, Ying G, Suzuki R, Yamamoto T, Oda K, Amizuka N
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Journal Title
J Electron Microsc
Volume: 59
Pages: 427-36
Related Report
Peer Reviewed
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[Journal Article] FGFR3 down-regulates PTH/PTHrP receptor gene expression by mediating JAK/STAT signaling in chondrocytic cell line2010
Author(s)
Li M, Seki Y, Freitas PH, Nagata M, Kojima T, Sultana S, Ubaidus S, Maeda T, Shimomura J, Henderson JE, Tamura M, Oda K, Liu Z, Guo Y, Suzuki R, Yamamoto T, Takagi R, Amizuka N
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Journal Title
J Electron Microsc
Volume: 59
Pages: 227-36
NAID
Related Report
Peer Reviewed
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[Journal Article] Immunolocalization of sclerostin synthesized by osteocytes in relation to bone remodeling in the interradicular septa of ovariectomized rats
Author(s)
Guo Y., Li M., Liu Z., Sasaki M., Hasegawa T., Hongo H., Tabata C., Suzuki R., Oda K., Yamamoto T., Kawanami M., Amizuka N.
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Journal Title
J Electron Microsc
Volume: (in press)
NAID
Related Report
Peer Reviewed
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[Journal Article] Morphological Aspects on Osteocytic Function on Bone Mineralization
Author(s)
Sasaki M., Hongo H., Hasegawa T., Suzuki R., Liu Z., Freitas PHL., Oda K., Yamamoto T., Li M., Totsuka Y., Amizuka N.
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Journal Title
Oral Science International
Volume: (in press)
Related Report
Peer Reviewed
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