Analysis of the salivatin function as incretin mimetics

• Project/Area Number: 21592363
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Functional basic dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: MIZUSAWA Noriko 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (80254746)
• Co-Investigator(Kenkyū-buntansha): IWATA Takeo 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (10350399) ; YOSHIMOTO Katsuhiko 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (90201863)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 糖尿病 / 膵島 / 唾液 / インクレチン / インスリン

Research Abstract

Incretin mimetics are a new class of pharmacological agents with multiple antihyperglycemic actions that mimic several of the actions of incretin hormones originating in the gut, such as glucagon-like peptide (GLP)-1.Salivatin supplied from salivary gland is a candidate to be new incretin mimetics. But the significant anti-hyperglycemic actions were unclear.

Research Products

• [Journal Article] Establishment of human dental epithelial cell lines expressing ameloblastin and enamelin by transfection of hTERT and cdk4 cDNAs (2011)
  • Author(s): S Hatakeyama, N Mizusawa, K Yoshimoto, Y Takeda
  • Journal Title: J Oral Pathol Med Volume: 40 Pages: 227-234
  • Peer Reviewed
• [Journal Article] Compressive force inhibits adipogenesis through COX-2-mediated down-regulation of PPARγ2 and C/EBPα (2010)
  • Author(s): MG Hossain, T Iwata, N Mizusawa, SW Shima, T Okutsu, K Ishimoto, K Yoshimoto
  • Journal Title: J Biosci Bioeng Volume: 109 Pages: 297-303
  • NAID: 110007612440
  • Peer Reviewed
• [Journal Article] High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer (2010)
  • Author(s): EL Wang, ZR Qian, K Yoshimoto, T Sano
  • Journal Title: Br J Cancer Volume: 102 Pages: 908-915
  • NAID: 120006812023
  • Peer Reviewed
• [Journal Article] Increased expression of HMGA1 correlates with tumour invasiveness and proliferation in human pituitary adenomas (2010)
  • Author(s): EL Wang, ZR Qian, MM Rahman, K Yoshimoto, S Yamada, E Kudo, T Sano
  • Journal Title: Histopathology Volume: 56 Pages: 501-509
  • Peer Reviewed
• [Journal Article] DNA methyltransferases 1, 3a, and 3b overexpression and clinical significance in gastroenteropancreatic neuroendocrine tumors (2010)
  • Author(s): MM Rahman, ZR Qian, EL Wang, K Yoshimoto, T Sano
  • Journal Title: Hum Pathol Volume: 41 Pages: 1069-1078
  • Peer Reviewed
• [Journal Article] Expression of p18^<INK4C> is down-regulated in human pituitary adenomas (2009)
  • Author(s): MG Hossain, T Iwata, N Mizusawa, ZR Qian, SW Shima, T Okutsu, S Yamada, T Sano, K Yoshimoto
  • Journal Title: Endocr Pathol Volume: 20 Pages: 114-121
  • Peer Reviewed
• [Journal Article] YKL-40 secreted from adipose tissue inhibits degradation of type I collagen (2009)
  • Author(s): T Iwata, M Kuwajima, A Sukeno, N Ishimaru, Y Hayashi, M Wabitsch, N Mizusawa, M Itakura, K Yoshimoto
  • Journal Title: Biochem Biophys Res Commun Volume: 388 Pages: 511-516
  • NAID: 120005708871
• [Journal Article] Identification of cis-acting promoter sequences required for expression of the glycerol-3-phosphate acyltransferase 1 gene in mice (2009)
  • Author(s): M Yoshida, N Harada, H Yamamoto, Y Taketani, T Nakagawa, K Yoshimoto, Y Nakaya
  • Journal Title: Biochim Biophys Acta Volume: 1791 Pages: 39-52
  • NAID: 120006631417
  • Peer Reviewed
• [Journal Article] Overexpression of HMGA2 relates to reduction of the let-7 and its relationship to clinicopathological features in pituitary adenomas (2009)
  • Author(s): ZR Qian, SL Asa, H Siomi, MC Siomi, K Yoshimoto, S Yamada, T Sano
  • Journal Title: Mod Pathol Volume: 22 Pages: 431-441
  • Peer Reviewed
• [Presentation] マウス膵島におけるisletasinの機能解析 (2011)
  • Author(s): 水澤典子
  • Organizer: 第54回日本糖尿病学会 学術集会
  • Place of Presentation: 札幌市(札幌プリンスホテル)(口演)
  • Year and Date: 2011-05-20
• [Presentation] Analysis of microRNA in saliva (2011)
  • Author(s): ワンナザトルシマ、水澤典子、岩田武男、吉本勝彦
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館(京都市)
• [Presentation] マウス膵島におけるisletasinの機能解析 (2011)
  • Author(s): 水澤典子、岩田武男、吉本勝彦
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: さっぽろ芸術 文化の館(札幌市)
• [Presentation] Analysis of microRNA in saliva and submandibular gland cell lines (2011)
  • Author(s): Wan Nazatul Shima, Noriko Mizusawa, Takeo Iwata, Katsuhiko Yoshimoto
  • Organizer: International Joint Symposium: The University of Tokushima, Universitas Gadjah Mada, Niigata University
  • Place of Presentation: Denpasar, Bali
• [Presentation] Analysis of microRNA in Saliva (2011)
  • Author(s): ワンナザトル シマ
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都市(国立京都国際会館)(口演)(ポスター)
• [Presentation] マウス膵島の単離 (2010)
  • Author(s): 木戸理恵、水澤典子、ワンナザトルシマ、岩田武男、吉本勝彦
  • Organizer: 126回徳島生物学会
  • Place of Presentation: 徳島大学(徳島市)
  • Year and Date: 2010-12-04
• [Presentation] D-dopachrome tautomeraseは脂肪細胞での中性脂肪量を制御する (2010)
  • Author(s): 岩田武男, 石本恭子, 水澤典子, 吉本勝彦
  • Organizer: 第52回歯科基礎医学会学術大会・総会
  • Place of Presentation: タワーホール船堀 東京(船堀)
• [Presentation] 唾液microRNAの解析 (2010)
  • Author(s): WanNazatul Shima, 水澤典子, 岩田武男, 吉本勝彦
  • Organizer: 第52回歯科基礎医学会学術大会・総会
  • Place of Presentation: タワーホール船堀 東京(船堀)
• [Presentation] 持続的圧縮力は前駆脂肪細胞からの脂肪細胞への分化を抑制する (2010)
  • Author(s): 岩田武男, Md. Golam Hossain, 水澤典子, 吉本勝彦
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山コンベンションセンター(岡山市)
• [Presentation] LXR アゴニストによるプログルカゴン遺伝子産生への影響. (2010)
  • Author(s): 水澤典子、岩田武男、ワン ナザトル シマ、吉本勝彦
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山コンベンションセンター(岡山市)
• [Presentation] Down-regulated expression of p18INK4C in pituitary adenomas (2010)
  • Author(s): Katsuhiko Yoshimoto, Md. Golam Hossain, Takeo Iwata, Noriko Mizusawa, Schadan Wan Nazatul Shima, Toru Okutsu, Kyoko Ishimoto, Zhi Rong Qian, Toshiaki Sano, Shozo Yamada
  • Organizer: 14^<th> International Congress of Endocrinology
  • Place of Presentation: Kyoto. Kyoto International Conference Center
• [Presentation] LXR アゴニストT0901317 によるプログルカゴン遺伝子発現への影響 (2009)
  • Author(s): 水澤典子、岩田武男、ワン ナザトル シマ、吉本勝彦
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2009-05-22
• [Presentation] YKL-40 secreted from macrophages infiltrating into adipose tissue inhibits degradation of type I collagen (2009)
  • Author(s): Iwata T, Kuwajima M, Sukeno A, Ishimaru N, Hayashi Y, Wabitsch M, Mizusawa N, Itakura M, Yoshimoto K
  • Organizer: International symposium on diabetes
  • Place of Presentation: Tokushima University,Tokushima (Japan)
  • Year and Date: 2009-03-16
• [Presentation] 脂肪組織におけるYKL-40 の役割 (2009)
  • Author(s): 岩田武男, 石丸直澄, 林良夫, 水澤典子, 吉本勝彦
  • Organizer: 第51回歯科基礎医学会学術大会
  • Place of Presentation: 白鷺メッセ(新潟市)
• [Presentation] Liver X receptor アゴニストによる消化管ホルモン発現調節 (2009)
  • Author(s): WanNazatul Shima, 水澤典子, 岩田武男, 吉本勝彦
  • Organizer: 第51回歯科基礎医学会学術大会
  • Place of Presentation: 白鷺メッセ(新潟市)
• [Presentation] hTERT およびcdk4遺伝子導入による不死化歯原性上皮細胞の樹立 (2009)
  • Author(s): 畠山節子, 堤玲子, 水澤典子, 吉本勝彦, 安本茂, 武田泰典
  • Organizer: 日本組織培養学会第82 回大会
  • Place of Presentation: 獨協医科大学創立30 周年記念館(栃木県壬生町)