| Project/Area Number |
21592423
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
YUMOTO Hiromichi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (60284303)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUO Takashi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (30173800)
OZAKI Kazumi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (90214121)
NAKANISHI Tadashi 徳島大学, 病院, 講師 (00217770)
NAKAE Hideaki 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (30227730)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 歯内療法学 / 根尖性歯周炎 / 電磁・高周波 / 細菌 / 骨芽細胞 / 遺伝子発現 / 成長因子 / シグナル伝達 / 歯内療法 / マイクロアレイ / オステオポンティン / バイオフィルム |
|---|
| Research Abstract |
The Electro-Magnetic Wave Irradiation(EMWI) exhibited great bactericidal activity(> 95. 65%) to kill various oral pathgens. This bactericidal activity by EMWI at 500 kHz(1 sec/ time) increased in an irradiation number-dependent manner. Moreover, EMWI activated MC3T3-E1 cell proliferation. After EMWI(500kHz, 5sec), various growth factors were upregulated. This study suggests that EMWI may contribute to the beneficial effects on bone tissue repair as regenerative therapy and be applicable to refractory periapical periodontitis.
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