Exploring dysfunction of centrally inhibiting muscle tone and descending inhibition of pain

• Project/Area Number: 21592468
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Prosthetic dentistry
• Research Institution: Keio University
• Principal Investigator: WAJIMA Koichi 慶應義塾大学, 医学部, 講師 (70138105)
• Co-Investigator(Kenkyū-buntansha): MURAOKA Wataru 慶應義塾大学, 医学部, 共同研究員 (70317254)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 筋性顎関節症 / 中枢感作 / 下行抑制系機能不全 / 熱刺激 / 閾値上侵害刺激 / 残感覚 / 時間的加算 / 顎関節症 / 筋障害 / 中枢性感作 / 筋抑制不全 / 下行抑制系不全 / 冷温痛覚刺激の時間的加重

Research Abstract

Central sensitization appears to play an important role in the pathophysiology of persistent orofacial pain. The primary aim of the present study was to compare patients with combined tension-type headache(TTH) and myofascial temporomandibular disorder(TMD) and control subjects on two measures of central processing, i. e., temporal summation(TS) and aftersensations to heat stimulation in the trigeminal nerve territory as well as spinal nerve.

Research Products

• [Journal Article] Lack of temporal summ ation but distinct after-sensations to thermal stimulation in patients with co mbined tension-type headache and myofas cial temporomandibular disorders (2012)
  • Author(s): Hitoshi Sato, Hironori Saisu, Wataru Muraoka, Taneaki Nakagawa, Peter Svenss on, Koichi Wajima
  • Journal Title: The Jo urnal of Orofacial Pain
  • Peer Reviewed
• [Journal Article] Lack of temporal summation but distinct aftersensations to thermal stimulation in patients with combined tension-type headache and myofascial temporomandibular disorders (2012)
  • Author(s): Hitoshi Sato, Hironori Saisu, Wataru Muraoka, Taneaki Nakagawa, Peter Svensson, Koichi Wajima
  • Journal Title: The Journal of Orofacial Pain Volume: (印刷中)
  • Peer Reviewed
• [Presentation] Diagnosis and treatment of orofacial pain attributed to muscle disorders (2011)
  • Author(s): Koichi Wajima
  • Organizer: 2011 annual meeting Taiwan academy of craniomandibular disorders
  • Place of Presentation: 台湾大学医学部、Taipei Taiwan
  • Year and Date: 2011-12-03
• [Presentation] Diagnosis and treatment of orofacial pain attributed to muscle disorders (2011)
  • Author(s): Koichi Wajima
  • Organizer: 2011 annual meeting Taiwan academy of cranio mandibular disorders
  • Place of Presentation: 台湾大学第8講堂(Taipei Taiwan)(招待講演)
  • Year and Date: 2011-12-03
• [Presentation] 三環系抗うつ薬が奏効した中枢性感作による治療抵抗性顎関節症2例 (2011)
  • Author(s): 井上裕梨、和嶋浩一, 他
  • Organizer: 第16回日本口腔顔面痛学会学術大会
  • Place of Presentation: 国際交流会館、神戸市
  • Year and Date: 2011-10-08
• [Presentation] 三環系抗うつ薬が奏効した中枢性感作による治療抵抗性顎関節症2例 (2011)
  • Author(s): 井上裕梨、和嶋浩一, 他
  • Organizer: 第16回日本口腔顔面痛学会学術大会
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2011-10-08
• [Presentation] アメリカの大規模研究にみる顎関節症の新しい流れ (2011)
  • Author(s): 和嶋浩一
  • Organizer: 第24回日本顎関節学会総会学術大会
  • Place of Presentation: 広島県民文化センター(広島県)
  • Year and Date: 2011-07-24
• [Presentation] アメリカの大規模研究にみる顎関節症の新しい流れ (2011)
  • Author(s): 和嶋浩一
  • Organizer: 第24回日本顎関節学会総会学術大会
  • Place of Presentation: 広島県民文化センター(広島県)(招待講演)
  • Year and Date: 2011-07-24
• [Presentation] 難治性歯痛の病態-非歯原性歯痛、特発性歯痛- (2011)
  • Author(s): 和嶋浩一
  • Organizer: 第65回日本口腔科学会総会学術大会
  • Place of Presentation: 東京都
  • Year and Date: 2011-04-21
• [Presentation] 難治性歯痛の病態-非歯原性歯痛、特発性歯痛- (2011)
  • Author(s): 和嶋浩一
  • Organizer: 第65回日本口腔科学会総会学術大会
  • Place of Presentation: タワーホール船堀(東京都)(招待講演)
  • Year and Date: 2011-04-21
• [Presentation] Central sensitization phenomena in orofacial pain patients-assessing after sensation upon application of heat- (2011)
  • Author(s): Koichi Wajima
  • Organizer: The Musculoskeletal Disorders and Chronic Pain conference
  • Place of Presentation: Los Angeles, California USA
• [Presentation] 慢性疼痛における中枢性感作の評価電気刺激感覚および温冷感覚閾値の標準値設定 (2009)
  • Author(s): 佐藤仁、和嶋浩一
  • Organizer: 第37回日本頭痛学会
  • Place of Presentation: 栃木県宇都宮市
  • Year and Date: 2009-11-29
• [Presentation] 慢性疼痛における中枢性感作の評価 電気刺激感覚および温冷感覚閾値の標準値設定 (2009)
  • Author(s): 佐藤仁, 和嶋浩一
  • Organizer: 第37回日本頭痛学会
  • Place of Presentation: 栃木県宇都宮市
  • Year and Date: 2009-11-29
• [Patent(Industrial Property Rights)] 中枢感作診断装置及びその動作方法 (2012)
  • Inventor(s): 和嶋浩一, 他
  • Industrial Property Rights Holder: 慶應義塾
  • Filing Date: 2012-02-20
• [Patent(Industrial Property Rights)] 中枢感作診断装置及びその動作方法 (2012)
  • Inventor(s): 和嶋浩一, 他
  • Industrial Property Rights Holder: 慶應義塾
  • Industrial Property Number: 2012-033972
  • Filing Date: 2012-02-20