Mesenchymal stem cells-photocurable gelatin-based gelation material for application to periodontal regeneration
Project/Area Number |
21592501
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Dental engineering/Regenerative dentistry
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Research Institution | Keio University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
MORIKAWA Satoru 慶應義塾大学, 医学部, 助教 (00424169)
HOSAKA Yasuo 慶應義塾大学, 医学部, 助教 (30246350)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 再生歯学 / 間葉系幹細胞 / 歯周組織再生 / 足場材料 / 光硬化型ゼラチン / 細胞分化誘導 / 組織再生 / 足場 / 幹細胞 / 光硬化性ゼラチン / 動物実験 |
Research Abstract |
We confirmed that prospective isolatedMSCs showed a 120, 000-fold higher colony forming frequency thanthe conventional MSCs. Furthermore, Our results suggested that MSCs in adultbone marrow have at least two developmental origins, one of which is the neural crest. Furthermore, prospectively enrichedMSCs are a promising candidate for the efficient generation of high-quality iPS cells. This photocurable solution also has adequate viscosity at room temperature before curing, and it manipulation is enhanced. It is assumed that forms suitable for various bone defects will thus be easily rendered, and it is also assumed that the shape can be retained with the mechanical strength required by photocurable.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Antibacterial activity of povidone-iodine against an artificial biofilm of Porphyromonas gingivalis and Fusobacterium nucleatum2012
Author(s)
Hosaka, Y., Saito, A., Maeda, R., Fukaya, C., Morikawa, S., Makino, A., Ishihara, K., Nakagawa, T
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Journal Title
Arch Oral Biol
Volume: 57
Issue: 4
Pages: 364-368
DOI
Related Report
Peer Reviewed
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[Journal Article] Purified Mesenchymal Stem Cells Are an Efficient Source for iPS Cell Induction2011
Author(s)
Kunimichi Niibe, Yoshimi Kawamura, Daisuke Araki, Satoru Morikawa, Kyoko Miura, Sadafumi Suzuki, Shigeto Shimmura, Takehiko Sunabori, Yo Mabuchi, Yasuo Nagai, Taneaki Nakagawa, Hideyuki Okano Yumi Matsuzaki.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Anti-IL-6-receptor antibody promotes repair of spinal cord injury by inducing microglia-dominant inflammation2010
Author(s)
Masahiko Mukaino, Masaya Nakamura, Osamu Yamada, Seiji Okada, Satoru Morikawa, Francois Renault-Mihara, Akio Iwanami, Takeshi Ikegami, Yoshiyuki Ohsugi, Osahiko Tsuji, Hiroyuki Katoh, Yumi Matsuzaki, Yoshiaki Toyama, Meigen Liu, and Hideyuki Okano
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Journal Title
Experimental Neurology Aug
Volume: 224(2)
Pages: 403-414
Related Report
Peer Reviewed
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[Journal Article] Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow2009
Author(s)
Satoru Morikawa, Yo Mabuchi, Yoshiaki Kubota, Yasuo Nagai, Kunimichi Niibe, Emi Hiratsu, Sadafumi Suzuki, Chikako Miyauchi-Hara, Narihito Nagoshi, Takehiko Sunabori, Shigeto Shimmura, Atsushi Miyawaki, Taneaki Nakagawa, Toshio Suda, Hideyuki Okano, and Yumi Matsuzaki
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Journal Title
The Journal of Experimental Medicine
Volume: 206(11)
Pages: 2483-2496
Related Report
Peer Reviewed
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[Presentation] Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow2010
Author(s)
Satoru Morikawa, Yo Mabuchi, Yoshiaki Kubota, Kunimichi Niibe, Narihito Nagoshi, Shigeto Shimmura, Taneaki Nakagawa, Toshio Suda, Hideyuki Okano, and Yumi Matsuzaki
Organizer
第9回日本再生医療学会総会
Place of Presentation
広島
Related Report
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