Antitumor effect of neutrophil-derived TRAIL for oral squamous cell carcinoma

• Project/Area Number: 21592562
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Tsurumi University (2011); Showa University (2009-2010)
• Principal Investigator: IWASE Masayasu 鶴見大学, 歯学部, 非常勤講師 (50193743)
• Co-Investigator(Kenkyū-buntansha): 栗原 祐史 昭和大学, 歯学部, 助教 (90514969) ; 羽鳥 仁志 昭和大学, 歯学部, 准教授 (20245814) ; 河野 葉子 昭和大学, 歯学部, 准教授 (40195681)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: TRAIL / 好中球 / アポトーシス / 抗腫瘍効果 / 臨床腫瘍学 / OK432 / インターフェロン / 分子標的治療 / デスレセプター

Research Abstract

BCG and OK432 enhanced TRAIL production and chemotaxis of neutrophils in a dose-dependent manner. Although TRAIL derived from neutrophils was insufficient cytotoxicity for squamous cell carcinoma cells, TRAIL from neutrophils possessed a priming effect for anti-tumor drugs or irradiation-induce cytotoxicity. These results are suggested that a combination of OK-432 and conventional therapy such as anti-tumor drugs and irradiation is a new anti-tumor strategy.

Research Products

• [Journal Article] Proteasome inhibitor sensitizes oral squamous cell carcinoma cells to TRAIL-mediated apoptosis (2011)
  • Author(s): SAYAKA YOSHIBA, MASAYASU IWASE, SAYAKA TAKAOKA, MAKIKO UCHIDA, YUJI KURIHARA, HITOSGI WATANABE, SATORU SHINTANI
  • Journal Title: Oncology Reports Volume: 25 Pages: 645-652
• [Journal Article] Protease inhibitor sensitizes oral squamous cell carcinoma cells to TRAIL-mediated apotpsis. (2011)
  • Author(s): Yoshiba S, Iwase K, et al
  • Journal Title: Oncol Rep Volume: 25 Pages: 645-652
  • Peer Reviewed
• [Presentation] Enhanced susceptibility to TRAIL-mediated apoptosis in oral squamous cell carcinoma cells through down-regulation of cellular FLIP (2009)
  • Author(s): MASAYASU IWASE, SAYAKA TAKAOKA, MAKIKO UCHIDA, SAYAKA YOSHIBA, TATSUO SHIROTA, MASASHI HATORI, SATORU SHINTANI
  • Organizer: 2nd World Congress of the International Academy of Oral Oncology
  • Place of Presentation: Toronto, Canada
• [Presentation] Enhanced susceptibility to TRAIL-mediated apoptosis in oral squamous cell carcinoma cells through down-regulation of cellular FLIP. (2009)
  • Author(s): Iwase M, Takaoka S, et al.
  • Organizer: 2nd World Congress of Oral Oncology
  • Place of Presentation: Toronto, Canada