Involvement of cytokine network in the pathology of neuropathic pain following peripheral nerve injury
| Project/Area Number |
21600017
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Kimiko 兵庫医科大学, 医学部, 助教 (70418961)
ARIMURA Yoshinobu 兵庫医科大学, 医学部, 助教 (30419824)
NAKANO Susumu 兵庫医科大学, 医学部, 助教 (40412019)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 末梢神経損傷 / マイクログリア / アストロサイト / TNF alpha / 脊髄後角 / 神経因性疼痛 / サイトカイン / 神経傷害性疼痛 / TNF受容体 |
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| Research Abstract |
Tumor necrosis factor(TNF)-alpha is one of a pro-inflammatory cytokines that may play a key role for the induction of neuropathic pain following nerve injury. However, the precise histological expression of TNF alpha and its receptors mRNA in the spinal cord after nerve injury is not fully understood. TNF alpha mRNA showed the transient increase from 18 hour and peaked at 24 hour following SNI. In the spinal cord of naive rats, TNF alpha and TNFR2 showed a low level expression and TNFR1 mRNA signal was detected in neurons and glial cells in the dorsal horn. Twenty-four hours after SNI, TNF alpha mRNA signals increased in the ipsilateral microglia. TNFR1 and TNF R2 mRNA signals increased strikingly in ipsilateral glial cells at 3 days after SNI.
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Report
(4 results)
Research Products
(8 results)
