| Project/Area Number |
21610029
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Children studies (Studies of environment on children)
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
SHIMADA Yoshiya 独立行政法人放射線医学総合研究所, 放射線防護研究センター, プログラムリーダー (10201550)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NISHIMURA Mayumi 独立行政法人放射線医学総合研究所, 放射線防護研究センター, 主任研究員 (70218204)
|
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| Co-Investigator(Renkei-kenkyūsha) |
KAKINUMA Shizuko 独立行政法人放射線医学総合研究所, 放射線防護研究センター, チームリーダー (20392219)
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|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 健康影響 / 胎児 / 放射線被ばく / 発達期被ばく / 放射線 / 発がん / 寿命短縮 |
|---|
| Research Abstract |
Assessing the impact of radiation exposure during fetal development and childhood, and identifying protective measures are matters of urgency. Using a mouse model, we analyzed the effect of the age-at-exposure on lifespan shortening, the accumulation of mutations in tissues, and the mutation frequency in induced cancers. The newborn period was found to be the most radiation-sensitive compared with fetal and adult stages, and the mutation frequency was altered in an age-dependent manner, providing an important oppotunity for further analysis.
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