| Project/Area Number |
21659238
|
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Sojo University (2011)
Tottori University (2009-2010) |
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Principal Investigator |
|
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| Co-Investigator(Renkei-kenkyūsha) |
KUROSAKI Hajime 鳥取大学, 大学院・医学系研究科, 助教 (70464295)
|
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,370,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | 分子血栓止血学 / 遺伝子治療 / 組換えタンパク / 血友病 / 遺伝子工学 / 細胞工学 / 移植・再生医療 / 遺伝子 / ゲノム / 組換えタンパク質 / 人工染色体 / iPS細胞 / ヒト人工染色体 / 血小板 / 血液凝固 / 第VIII因子 / 凝固因子 / 血液凝固因子 / 凝固第VIII因子 |
|---|
| Research Abstract |
Human artificial chromosome(HAC) vectors show considerable promise for gene therapy applications as they have the capacity to deliver an extremely large genetic region and are stably maintained independent of the host chromosome, thus diminishing risks of insertional mutagenesis. In this study, we have developed HAC vectors for gene therapy of hemophilia.
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