The probe design strategy of post-FDG tumor diagnostic agents based on the functional biomolecule expression analysis of human cultured cells

• Project/Area Number: 21659286
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: KAWAI Keiichi 金沢大学, 保健学系, 教授 (30204663)
• Co-Investigator(Renkei-kenkyūsha): TAMAI Ikumi 金沢大学, 薬学系, 教授 (20155237) ; FUJIBAYASHI Yasuhisa 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, センター長 (50165411)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,270,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,100,000 (Direct Cost: ¥1,100,000); Fiscal Year 2009: ¥1,000,000 (Direct Cost: ¥1,000,000)
• Keywords: ヒト培養細胞 / 機能性分子発現解析 / ポストFDG / 腫瘍診断薬 / PET製剤 / 腫瘍集積性 / アミノ酸トランスポータ / 設計戦略

Research Abstract

While searching this research for the functional biomolecule used by the database for the gene expression level of the human cultured cells for evaluation of imaging probes, and it has high-expressed to the tumor cell beforehand, the amino acid derivatives are especially taken up also in a post-FDG candidate probe, and the accumulation mechanism of the labeled amino acids which shows high affinity to the amino acid transporters to which high revelation is specifically accepted by a tumor was examined in detail, and the validity of the design strategy was evaluated from correlation with amino acid transporter gene expression and tumor accumulation of the probes.

Research Products

• [Journal Article] Down-regulation of Calcium/calmodulin-dependent Protein Kinase Kinase 2 by Androgen Deprivation Induces Castration-resistant ProstateCancer (2012)
  • Author(s): Shima T., Mizokami A., Miyagi T., Kawai K., Izumi K., Kumaki M., Ofude M., Zhang J., Keller E. T. and Namiki M
  • Journal Title: Prostate in press Volume: (in press)
• [Journal Article] Cerebral Oxygen Metabolism of Rats using Injectable O^<15>-Oxygen with a Steady-state Method (2012)
  • Author(s): Kobayashi M., Mori T., Kiyono Y., Tiwari V., Maruyama R., Kawai K., Okazawa H
  • Journal Title: J. Cereb. Blood Flow Metab Volume: 32 Pages: 33-40
• [Journal Article] Appropriate Parameters of Ordered-Subset Expectation Maximization Algorithm on Measurement of Myocardial Blood Flow and Oxygen Consumption with C^<11>-Acetate PET (2012)
  • Author(s): Kobayashi M., Mori T., Kiyono Y., TsujikawaT., Maruyama R., Higaki Y., Shikano N., Nishii R., Kawai K., Kudo T., Okazawa H
  • Journal Title: Nucl. Med. Commun Volume: 33 Pages: 130-138
• [Journal Article] Cerebral Oxygen Metabolism of Rats using Injectable ^<15>O-Oxygen with a Steady-state Method (2012)
  • Author(s): Kobayashi M., Mori T., Kawai K., et al
  • Journal Title: J.Cereb.Blood Flow Metab. Volume: 32(reviewed) Pages: 33-40
• [Journal Article] The Agreement of Left Ventricular Function Parameters between ^<99m>Tc-Tetrofosmin Gated Myocardial SPECT and Gated Myocardial MRI (2012)
  • Author(s): Kuroiwa Y., Nagamachi S., Kawai K., et al
  • Journal Title: Ann.Nucl.Med. Volume: 26(reviewed) Pages: 147-163
  • NAID: 10030623502
• [Journal Article] Down-regulation of Calcium/calmodulin-dependent Protein Kinase Kinase 2 by Androgen Deprivation Induces Castration-resistant Prostate Cancer (2012)
  • Author(s): Shima T., Mizokami A., Kawai K., et al
  • Journal Title: Prostate Volume: (reviewed)(in press)
• [Journal Article] Functional Characterization of Apical Transporters Expressed in Rat Proximal Tubular Cells(PTCs) in Primary Culture (2011)
  • Author(s): Nakanishi T., Fukushi A., Sato M., Yoshifuji M., Gose T., Shirasaka Y., Ohe K., Kobayashi M., Kawai K., Tamai I
  • Journal Title: Mol. Pharm Volume: 8 Pages: 2142-2150
• [Journal Article] Putative Transport Mechanism and Intracellular Fate of Anti-18F-FACBC(Trans-1-amino-3-F^<18>-fluorocyclobutanecarboxylic Acid) in Human Prostate Cancer (2011)
  • Author(s): Okudaira H., Shikano N., Nishii R., Miyagi T., Yoshimoto M., Kobayashi M., Ohe K., Nakanishi T., Tamai I., Namiki M., Kawai K
  • Journal Title: J. Nucl. Med Volume: 52 Pages: 822-829
• [Journal Article] Differential Expression of FosB, c-Fos, and Zif268 in Forebrain Regions after Acute or Chronic L-DOPA Treatment in a RatModel of Parkinson's Disease (2011)
  • Author(s): Ebihara K., Ishida Y., Takeda R., Abe H., Matsuo H., Kawai K., Magata Y., Nishimori T
  • Journal Title: Neurosci. Lett Volume: 496 Pages: 90-94
• [Journal Article] Development of an H_2^<15> O Steady-state Method Combining a Bolus and Slow Increasing Injection with a Multiprogramming Syringe Pump (2011)
  • Author(s): Kobayashi M., Kiyono Y., Maruyama R., MoriT., Kawai K., Okazawa H
  • Journal Title: J. Cereb. Blood Flow Metab Volume: 31 Pages: 527-534
• [Journal Article] Putative Transport Mechanism and Intracellular Fate of Anti-^<18>F-FACBC (Trans-1-amino-3-^<18>F-fluorocyclobutanecarboxylic Acid) in Human Prostate Cancer (2011)
  • Author(s): Okudaira H., Yoshimoto M., Kawai K., et al
  • Journal Title: J.Nucl.Med. Volume: 52(reviewed) Pages: 822-829
• [Journal Article] Comparison of Diagnostic and Prognostic Capabilities of ^<18>F-FDG PET/CT, ^<131>I-scintigraphy, and Diffusion-weighted Magnetic Resonance Imaging for Postoperative Thyroid Cancer (2011)
  • Author(s): Nagamachi S., Wakamatsu H., Kawai K., et al
  • Journal Title: Jpn.J.Radiol. Volume: 29(reviewed) Pages: 413-422
  • NAID: 50008099143
• [Journal Article] Functional Characterization of Apical Transporters Expressed in Rat Proximal Tubular Cells (PTCs) in Primary Culture (2011)
  • Author(s): Nakanishi T., Fukushi A., Kawai K., et al
  • Journal Title: Mol.Pharm. Volume: 8(reviewed) Pages: 2142-2150
• [Journal Article] Development of an H_2^<150> Steady-state Method Combining a Bolus and Slow Increasing Injction with a Multiprogramming Syringe Pump (2011)
  • Author(s): Kobavashi M., Kiyono Y., Kawai K., et al
  • Journal Title: J.Cereb.Blood Flow Metab. Volume: 31(reviewed) Pages: 527-534
• [Journal Article] Putative Trmsport Mechanism and Intracellular Fate of Anti-^<18>F-FACBC(Trans-1-amino-3-^<18>F-fluorocyclobutanecarboxylic Acid)in Human Prostate Cancer (2011)
  • Author(s): Okudaira H., Yoshimoto M., Kobayashi M., Kawai K., et al
  • Journal Title: J.Nucl.Med Volume: in press(reviewed)
• [Journal Article] Differential Expression of FosB, c-Fos, and Zif268 in Forebrain Regions after Acuteor Chronic L-DOPA Treatment in a Rat Model of Parkinson's Disease. (2011)
  • Author(s): Ebihara K., Ishida Y., Kawai K., Magata Y., et al
  • Journal Title: Neurosci.Lett. Volume: in press(reviewed)
• [Journal Article] Radioiodinated 4-Iodo-L-meta-tyrosine, a System L Selective Artificial Amino Acid : Molecular Design and Transport Characterizationin in Chinese Hamster Ovary Cells(CHO-K_1 Cells) (2010)
  • Author(s): Shikano N., Kotani T., Nakajima S., OguraM., Nakazawa S., Sagara J., Kobayashi M., Nakazawa S., Baba T., Yamaguchi N., Kubota N., Iwamura Y., Kawai K
  • Journal Title: Nucl. Med. Biol Volume: 37 Pages: 903-910
• [Journal Article] Comparison of theTranscellular Transport of FDG and D-Glucose by the Kidney Epithelial Cell Line LLC-PK_1 (2010)
  • Author(s): Kobayashi M., Shikano N., Nishii R., KiyonoY., Araki H., Nishi K., Oh M., Okudaira H., Ogura M., Yoshimoto M., Okazawa H., Fujibayashi Y., Kawai K
  • Journal Title: Nucl. Med. Commun Volume: 31 Pages: 141-146
• [Journal Article] Uptake of 3-[ I^<125>] Iodo-α-methyl-L-tyrosine intoColon Cancer DLD-1 Cells : Characterization and Inhibitory Effect of Natural Amino Acids and Amino Acid-likeDrugs (2010)
  • Author(s): Shikano N., Ogura M., Okudaira H., Nakajima S., Kotani T., Kobayashi M., Nakazawa S., Baba T., Yamaguchi N., Kubota N., Iwamura Y., Kawai K
  • Journal Title: Nucl. Med. Biol Volume: 37 Pages: 197-204
• [Journal Article] Stimulation of I^<125>-3-Iodo-alpha-methyl-L-tyrosine in Chinese Hamster Ovary(CHO-K1) Cells by Tyrosine Esters (2010)
  • Author(s): Shikano N., Ogura M., Sagara J., Nakajima S., Kobayashi M., Baba T., Yamaguchi N., Iwamura Y., Kubota N., Kawai K
  • Journal Title: Nucl. Med. Biol Volume: 37 Pages: 189-196
• [Journal Article] Comparison of the Transcellular Transport of FDG and D-Glucose by the Kidney Epithelial Cell Line LLC-PKI. (2010)
  • Author(s): Kobayashi M.Yoshimoto M., Kawai K., et al.
  • Journal Title: Nucl.Med.Commun. Volume: 31(reviewed) Pages: 141-146
• [Journal Article] Stimulation of ^<125>I-3-Iodo-alpha-methyl-L-tyrosine in Chinese Hamster Ovary(CHO-K_1) Cells by Tyrosine Esters. (2010)
  • Author(s): Shikano N., Kobayashi M., Kawai K., et al
  • Journal Title: Nucl.Med.Biol. Volume: 37(reviewed) Pages: 189-196
• [Journal Article] Uptake of 3-[^<125>I]Iodo-a-methyl-L-tyrosine into Colon Cancer DLD-1 Cells : Characterization and Inhibitory Effect of Natural Amino Acids and Amino Acid-likeDrugs. (2010)
  • Author(s): Shikano N., Kobavashi M., Kawai K., et al
  • Journal Title: Nucl.Med.Biol. Volume: 37(reviewed) Pages: 197-204
• [Journal Article] The Reproducibility of Deep-inspiration Breath-hold ^<18>F-FDG PET/CT Technique in Diagnosing Various Cancers Affected by Respiratory Motion. (2010)
  • Author(s): Nagamachi S., Wakamatsu H., Kawai K., et al
  • Journal Title: Ann.Nucl.Med. Volume: 24(reviewed) Pages: 171-178
  • NAID: 10026390940
• [Journal Article] Inhibition of Cisplatin Protein Binding : a Possible Therapeutic Advantage. (2010)
  • Author(s): Tokunaga J., Matsuo Y., Kawai K., et al
  • Journal Title: J.Appl.Therapeutic Res. Volume: 7(reviewed) Pages: 127-132
• [Journal Article] The Citrus Flavonoids Hesperetin and Naringenin Block the Lipolytic Actions of TNF-a in Mouse Adipocytes. (2010)
  • Author(s): Yoshida H., Takamura N., Kawai K., et al
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 394(reviewed) Pages: 728-732
• [Journal Article] Superior Plasma Retention of a Cross-linked Human Serum Albumin Dimer in Nephrotic Rats as a New Type of Plasma Expander. (2010)
  • Author(s): Taguchi K., Urata Y., Kawai K., et al.
  • Journal Title: Drug Metab.Dispos. Volume: 38(reviewed) Pages: 2124-2129
• [Journal Article] Radioiodinated 4-Iodo-L-meta-tyrosine, a System L Selective Artificial Amino Acid : Molecular Design and Transport Characterizationin in Chinese Hamster Ovary Cells(CHO-K_1 Cells). (2010)
  • Author(s): Shikano N., Kobayashi M., Kawai K., et al
  • Journal Title: Nucl.Med.Biol. Volume: 37(reviewed) Pages: 903-910
• [Journal Article] Atherosclerotic Lesions Rich in Macrophages or Smooth Muscle Cells Discriminated in Rabbit Iliac Arteries Based on T1 Relaxation Time and Lipid Content. (2010)
  • Author(s): Kuroiwa Y., Yamashita A., Kawai K., et al
  • Journal Title: Acad.Radiol. 17 Pages: 230-238
  • Peer Reviewed
• [Journal Article] ^<18>F-FDGを用いた脳PET検査の健常者データベースにおけるTransmission撮像および減弱補正法の影響. (2010)
  • Author(s): 小林正和, 杉本勝也, 川井恵一, 他
  • Journal Title: 日本放射線技術学会雑誌 66 Pages: 42-48
  • NAID: 10025978080
  • Peer Reviewed
• [Journal Article] Comparison of the Transcellular Transport of FDG and D-Glucose by the Kidney Epithelial Cell Line LLC-PK_1. (2010)
  • Author(s): Kobayashi M., Yoshimoto M., Kawai K., et al
  • Journal Title: Nucl.Med.Commun. 31 Pages: 141-146
  • Peer Reviewed
• [Journal Article] Stimulation of ^<125>I-3-Iodo-alpha-methyl-L-tyrosine in Chinese Hamster Ovary(CHO-K_1)Cells by Tyrosine Esters. (2010)
  • Author(s): Shikano N., Kobayashi M., Kawai K., et al
  • Journal Title: Nucl.Med.Biol. 37 Pages: 189-196
  • Peer Reviewed
• [Journal Article] Uptake of 3-[^<125>I]Iodo-α-methyl-L-tyrosine into Colon Cancer DLD-1 Cells : Characterization and Inhibitory Effect of Natural Amino Acids and Amino Acid-like Drugs. (2010)
  • Author(s): Shikano N., Kobayashi M., Kawai K., et al
  • Journal Title: Nucl.Med.Biol. 37 Pages: 197-204
  • Peer Reviewed
• [Journal Article] The Reproducibility of Deep-inspiration Breath-hold ^<18>F-FDG PET/CT Technique in Diagnosing Various Cancers Affected by Respiratory Motion. (2010)
  • Author(s): Nagamachi S., Wakamatsu H., Kawai K., et al
  • Journal Title: Ann.Nucl.Med. (in press)
  • NAID: 10026390940
  • Peer Reviewed
• [Journal Article] The Citrus Flavonoids Hesperetin and Naringenin Block the Lipolytic Actions of TNF-α in Mouse Adipocytes. (2010)
  • Author(s): Yoshida H., Takamura N., Kawai K., et al
  • Journal Title: Biochem.Biophys.Res.Commun. (in press)
  • Peer Reviewed
• [Journal Article] Evaluation of Radioiodinated Vesamicol Analogs for Sigma Receptor Imaging in Tumor and Radionuclide ReceptorTherapy (2009)
  • Author(s): Ogawa K., Shiba K., Akhter N., YoshimotoM., Washiyama K., Kinuya S., Kawai K., Mori H
  • Journal Title: Cancer Sci Volume: 100 Pages: 2188-2192
  • NAID: 10027197320
• [Journal Article] Improvement of N-isopropyl-p-[ I^<123>] iodoamphetamine Cerebral Accumulation by Competitive Displacement of Serum Protein Binding with Amino-Acid Infusion (2009)
  • Author(s): Kuga N., Shikano N., Takamura N., Nishii R., Yamasaki K., Kobayashi M., Nagamachi S., Tamura S., Kawai K
  • Journal Title: J. Nucl. Me Volume: 50 Pages: 1378-1383
• [Journal Article] Intracellular Reactions Affecting 2-Amino-4-([ C^<11>] methylthio) butyricacid([ C^<11>] Methionine) Response to Carbon Ion Radiotherapy in C10 Glioma Cells (2009)
  • Author(s): Uehara T., Nakagawa M., Takai N., Koike S., Furusawa Y., Ando K., Kawai K., Akizawa H., Irie T., Arano Y
  • Journal Title: Nucl. Med. Biol Volume: 36 Pages: 985-991
• [Journal Article] Serum Protein Binding Displacement : Theoretical Analysis using a Hypothetical Radiopharmaceutical and Experimental Analysis with ^<123>I-N-isopropyl-p-iodoamphetamine. (2009)
  • Author(s): Kawai K., Nishii R., Yoshimoto M., et al
  • Journal Title: Nucl.Med.Biol. 36 Pages: 99-106
  • Peer Reviewed
• [Journal Article] Usefulness of Competitive Inhibitors of Protein Binding for Improving the Pharmacokinetics of ^<186>Re-MAG3-conjugated Bisphosphonate(^<186>Re-MAG_3-HBP), an Agent for Treatment of Painful Bone Metastases. (2009)
  • Author(s): Ogawa K., Mukai T., Kawai K., et al
  • Journal Title: Eur.J.Nucl.Med.Mol.Imaging 36 Pages: 115-121
  • Peer Reviewed
• [Journal Article] Altered Chain-length and Glycosylation Modify the Pharmacokinetics of Human Serum Albumin. (2009)
  • Author(s): Iwao Y., Hiraike M., Kawai K., et al
  • Journal Title: Biochim.Biophys.Acta 1794 Pages: 634-641
  • Peer Reviewed
• [Journal Article] Usefulness of a Deep-inspiration Breath-hold ^<18>F-FDG PET/CT Technique in Diagnosing Liver, Bile Duct, and Pancreas Tumors. (2009)
  • Author(s): Nagamachi S., Wakamatsu H., Kawai K., et al
  • Journal Title: Nucl.Med.Commun. 30 Pages: 326-332
  • Peer Reviewed
• [Journal Article] Intracellular Reactions Affecting 2-Amino-4-([^<11>C]methylthio)butyric acid([^<11>C]Methionine)Response to Carbon Ion Radiotherapy in C10 Glioma Cells. (2009)
  • Author(s): Uehara T., Nakagawa M., Kawai K., et al
  • Journal Title: Nucl.Med.Biol. 36 Pages: 985-991
  • Peer Reviewed
• [Journal Article] Improvement of N-isopropyl-p-[^<123>I]iodoamphetamine Cerebral Accumulation by Competitive Displacement of Serum Protein Binding with Amino-Acid Infusion. (2009)
  • Author(s): Kuga N., Shikano N., Kawai K., et al
  • Journal Title: J.Nucl.Med. 50 Pages: 1378-1383
  • Peer Reviewed
• [Journal Article] Evaluation of Radioiodinated Vesamicol Analogs for Sigma Receptor Imaging in Tumor and Radionuclide Receptor Therapy. (2009)
  • Author(s): Ogawa K., Yoshimoto M., Kawai K., et al
  • Journal Title: Cancer Sci. 100 Pages: 2188-2192
  • NAID: 10027197320
  • Peer Reviewed
• [Presentation] 放射性医薬品の体内動態制御と薬物代謝機能診断法開発の可能性 (2012)
  • Author(s): 川井恵二
  • Organizer: 埼玉医科大学第3回腫瘍内科セミナー特別講演
  • Place of Presentation: 埼玉医科大学国際医療センター(埼玉県)(招待講演)
  • Year and Date: 2012-03-02
• [Presentation] Transport Mechanism of Trans-1-amino-3-F^<18>-fluorocyclobutanecarboxylic Acid(F^<18>-FACBC) in Human Prostate Cancer (2012)
  • Author(s): Okudaira H., Shikano N., Nishii R., Miyagi T., Yoshimoto M., Kobayashi M., Ohe K., Nakanishi T., Namiki M., Tamai I., Kawai K
  • Organizer: International Symposium on Past, Present and Future of Molecular Pharmacokinetics
  • Place of Presentation: University of Tokyo(Japan)
  • Year and Date: 2012-01-16
• [Presentation] Transport Mechanism of Trans-1-amino-3-^<18>F-fluorocyclobutanecarboxylic Acid (^<18>F-FACBC) in Human Prostate Cancer (2012)
  • Author(s): Okudaira H., Shikano N., Kawai K., et al
  • Organizer: International Symposium on Past, Present and Future of Molecular Pharmacokinetics
  • Place of Presentation: Univ.Tokyo (Tokyo, Japan)
  • Year and Date: 2012-01-16
• [Presentation] 放射性医薬品の開発・体内動態制御と個別化医療 (2011)
  • Author(s): 川井恵一
  • Organizer: バイオセミナー"未来へのバイオ技術"月例会
  • Place of Presentation: バイオインダストリー協会(東京都)
  • Year and Date: 2011-12-05
• [Presentation] 放射性医薬品の開発・体内動態制御と個別化医療 (2011)
  • Author(s): 川井恵一
  • Organizer: バイオインダストリー協会バイオセミナー"未来へのバイオ技術"月例会
  • Place of Presentation: バイオインダストリー協会(東京都)(招待講演)
  • Year and Date: 2011-12-05
• [Presentation] System A Amino Acid Transport PET Imaging with C-11 MeAIB in Patient with Glioblastoma Multiforme (2011)
  • Author(s): Nishii R., Higashi T., Kawai K., et al
  • Organizer: World Molecular Imaging Congress 2011
  • Place of Presentation: San Diego Convention Center (U.S.A.)
  • Year and Date: 2011-09-07
• [Presentation] Usefulness of Double Tracer PET Study using[ F^<18>] FDG and Amino Acid Radiotracer,[ C^<11>] MeAIB, in the Diagnosis of Mediastinal Diseases (2011)
  • Author(s): Higashi T., Nishii R., Kagawa S., Kishibe Y., Takahashi M., Kobayashi M., Kawai K
  • Organizer: The Society of Nuclear Medicine 58th Annual Meeting
  • Place of Presentation: San Antonio Convention Center(U. S. A.)
  • Year and Date: 2011-06-04
• [Presentation] アイソトープ施設と他分野連携研究 (2011)
  • Author(s): 川井恵一
  • Organizer: 平成22年度北海道地区大学等放射線施設協議会アイソトープ利用研究会特別講演
  • Place of Presentation: 北海道大学(北海道)[招待講演]
  • Year and Date: 2011-02-04
• [Presentation] Usefulness of Double Tracer PET Study using [^<18>F]FDG and Amino Acid Radiotracer, [^<11>C]MeAIB, in the Diagnosis of Mediastinal Diseases (2011)
  • Author(s): Higashi T., Nishii R., Kawai K., et al
  • Organizer: The Society of Nuclear Medicine 58th Annual Meeting
  • Place of Presentation: San Antonio Convention Center (U.S.A.)
• [Presentation] 薬物体内動態制御法と薬物療法の適正化を目指した個別化変動要因モニタリング法の開発 (2010)
  • Author(s): 川井恵一
  • Organizer: 第7回次世代医療システム産業化フォーラム2010定例研究会
  • Place of Presentation: 京都商工会議所(京都府)[招待講演]
  • Year and Date: 2010-12-21
• [Presentation] Clinical Application of System A Amino Acid Transport PET Imaging with [^<11>C] MeAIB. (2010)
  • Author(s): Nishii R., Higashi T., Kawai K., et al
  • Organizer: International Joint Symposium of the 8th Symposium for Future Drug Discovery and Medical Care and the 5th Symposium of the Research Center for Cooperative Projects
  • Place of Presentation: Univ.Hokkaido(Sapporo, Japan)
  • Year and Date: 2010-09-01
• [Presentation] Effects of Antiangiogenic Drugs on FDG, FLT and Methionine Uptake in LS180 and HUVEC (2010)
  • Author(s): Yoshimoto M., Kinuya S., Kawai K
  • Organizer: The Society of Nuclear Medicine 57th Annual Meeting
  • Place of Presentation: Salt Palace Convention Center(U. S. A.)
  • Year and Date: 2010-06-05
• [Presentation] Effects of Antiangiogenic Drugs on FDg FLT and Methionine Uptake in LS 180 and HWEC. (2010)
  • Author(s): Yoshimoto M., Kinuya S., Kawai K., et al
  • Organizer: The Society of Nuclear Medicine 57th Annual Meeting
  • Place of Presentation: Salt Lake City(U.S.A.)
  • Year and Date: 2010-06-05
• [Presentation] Accumulation and Transport Mechanism of Anti-1-Amino-3[^<18>F]fluorocyclobutane-1-carboxylic Acid in Representative Human Carcinomas. (2010)
  • Author(s): Kobavashi M., Yoshimoto M., Kawai K., et al
  • Organizer: The Society of Nuclear Medicine 57th Annual Meeting
  • Place of Presentation: Salt Lake City(U.S.A.)
  • Year and Date: 2010-06-05
• [Presentation] Estimation of Radioiodinated PYK as an Imaging Agent for Assessment of EGFR-TKActivity. (2010)
  • Author(s): Yoshimoto M., Hirata M., Kawai K., et al
  • Organizer: The Society of Nuclear Medicine 57th Annual Meeting
  • Place of Presentation: Salt Lalce Ciry(U.S.A.)
  • Year and Date: 2010-06-05
• [Presentation] Usefulness of New Amino Acid Radiotracer, [^<11>C]MeAIB, in the Oncologic PET Diagnosis of Chest Malignancies. (2010)
  • Author(s): Higashi T., Kawai K., Kobayashi M., et al
  • Organizer: The Society of Nuclear Medicine 57th Annual Meeting
  • Place of Presentation: Salt Lake City(U.S.A.)
  • Year and Date: 2010-06-05
• [Presentation] Accumulation and Transport Mechanism of Anti-1-Amino-3-[ F^<18>] fluorocyclobutane-1-carboxylic Acid in Representative Human Carcinomas (2010)
  • Author(s): Kobayashi M., Kagawa S., Nishii R., Takahashi F., Ohe K., Yoshimoto M., Shikano N., Higashi T., Nagamachi S., KawaiK
  • Organizer: The Society of Nuclear Medicine 57th Annual Meeting
  • Place of Presentation: Salt Palace Convention Center(U. S. A.)
  • Year and Date: 2010-05-06
• [Presentation] Assessment of Efficacy of[ C^<11>]-MeAIB PET as a Biomarker of the System A Amino Acid Transport : Comparison with[ 11C^<11>]-MET PET and[ F^<18>]-FDG PET in the Patients with Glioblastoma Multiforme (2010)
  • Author(s): Nishii R., Higashi T., Kagawa S., Kishibe Y., Takahashi M., Kobayashi M., Kawai K., Nagamachi S
  • Organizer: The Society of Nuclear Medicine 57th Annual Meeting
  • Place of Presentation: Salt Palace Convention Center(U. S. A.)
  • Year and Date: 2010-05-06
• [Presentation] 放射性医薬品の体内動態制御とターゲティングコンファーマティヴ個別化医療 (2010)
  • Author(s): 川井恵一
  • Organizer: 第66回日本放射線技術学会総会学術大会
  • Place of Presentation: パシフィコ横浜会議センター(神奈川県)
  • Year and Date: 2010-04-09
• [Presentation] 放射性医薬品の体内動態制御とターゲッティングコンファーマティヴ個別化医療 (2010)
  • Author(s): 川井恵一
  • Organizer: 第66回日本放射線技術学会総会学術大会教育講演
  • Place of Presentation: パシフィコ横浜(神奈川県)[招待講演]
  • Year and Date: 2010-04-09
• [Presentation] 核医学分子イメージングによるがん治療モニタリングと個別化医療への応用. (2009)
  • Author(s): 川井恵一
  • Organizer: 第2回重点戦略中核拠点形成-可視化と個別化医療-シンポジウム
  • Place of Presentation: 金沢大学角間キャンパス(石川県)
  • Year and Date: 2009-12-07
• [Presentation] System A and System L Amino Acid Transport Imaging with ^<11>C MeAIB and ^<11>C METPET Study. (2009)
  • Author(s): Nishii R., Higashi T., Kawai K., et al
  • Organizer: World Molecular Imaging Congress 2009
  • Place of Presentation: Palais des Congres de Montreal(Canada)
  • Year and Date: 2009-09-23
• [Presentation] Trans-stimulation of 3-I-125-Iodo-alpha-methyl-L-tyrosine Uptake into Chinese Hamster Ovary Cell by Amino Acid Esters (2009)
  • Author(s): Shikano N., Ogura M., Nakajima S., YamaguchiN., Kubota N., Iwamura Y., Kawai K
  • Organizer: 18th International Symposium on Radiopharmaceutical Sciences
  • Place of Presentation: Edmonton's Shaw Conference Centre(Canada)
  • Year and Date: 2009-07-12
• [Presentation] Uptake Inhibition of 3-I-125-Iodoalpha-methyl-L-tyrosine into Colon Cancer DLD-1 Cell by Amino Acid Like Drugs (2009)
  • Author(s): Ogura M., Shikano N., Nakajima S., Yamaguchi N., Kubota N., Iwamura Y., KawaiK
  • Organizer: 18th International Symposium on Radiopharmaceutical Sciences
  • Place of Presentation: Edmonton's Shaw Conference Centre(Canada)
  • Year and Date: 2009-07-12
• [Presentation] Serum Protein Binding Displacement : Theoretical Analysis using a Hypothetical Radiopharmaceutical. (2009)
  • Author(s): Shikano N., Kobayashi M., Kawai K., et al
  • Organizer: 18th International Symposium on Radiopharmaceutical Sciences
  • Place of Presentation: Northlands Agricom(Edmonton, Canada)
  • Year and Date: 2009-07-12
• [Presentation] Trans-stimulation of 3-I-125-Iodo-alpha-methyl-L-tyrosine Uptake into Chinese Hamster Ovary Cell by Amino Acid Esters. (2009)
  • Author(s): Shikano N., Ogura M., Kawai K., et al
  • Organizer: 18th International Symposium on Radiopharmaceutical Sciences
  • Place of Presentation: Northlands Agricom(Edmonton, Canada)
  • Year and Date: 2009-07-12
• [Presentation] Uptake Inhibition of 3-I-125-Iodo-alpha-methyl-L-tyrosine into Colon Cancer DLD-1 Cell by Amino Acid Like Drugs. (2009)
  • Author(s): Ogura M., Shikano N., Kawai K., et al
  • Organizer: 18th International Symposium on Radiopharmaceutical Sciences
  • Place of Presentation: Northlands Agricom(Edmonton, Canada)
  • Year and Date: 2009-07-12
• [Presentation] Mechanism of Renal FDG Transcellular Transport and Cellular Accumulation using LLC-PK_1 Cells (2009)
  • Author(s): Kobayashi M., Araki H., Nishi K., Shikano N., Kiyono Y., Nishii R., Fujibayashi Y., Okazawa H., Kawai K
  • Organizer: The Society of Nuclear Medicine 56th Annual Meeting
  • Place of Presentation: Metro TorontoConvention Center(U. S. A.)
  • Year and Date: 2009-06-13
• [Presentation] Mechanism of Renal FDG Transcellular Transport and Cellular Accumulation using LLC-PK_1 Cells (2009)
  • Author(s): Kobayashi M., Araki H., Nishi K., Shikano N., Kiyono Y., Nishii R., Fujibayashi Y., Okazawa H., Kawai K
  • Organizer: The Society of Nuclear Medicine 56th Annual Meeting
  • Place of Presentation: Metro Toronto Convention Center(U. S. A.)
  • Year and Date: 2009-06-13
• [Presentation] Comparison of System A and System L Amino Acid Transports in Human Pancreas with C-11 MeAIB and C-11 MET PET Study (2009)
  • Author(s): Nishii R., Kagawa S., Higashi T., Kishibe Y., Iwasaki T., Uehara T., Kobayashi M., Nagamachi S., Arano Y., Kawai K
  • Organizer: The Society of Nuclear Medicine 56th Annual Meeting
  • Place of Presentation: Metro Toronto Convention Center(U. S. A.)
  • Year and Date: 2009-06-13
• [Presentation] Estimation of Sensitivity to Gefitinib with Radioiodinated IPHY in Lung Cancer (2009)
  • Author(s): Yoshimoto M., Hirata M., Kawai K., OhmomoY
  • Organizer: The Society of Nuclear Medicine 56th Annual Meeting
  • Place of Presentation: Metro Toronto Convention Center(U. S. A.)
  • Year and Date: 2009-06-13
• [Presentation] Estimation of Sensitivity to Gefitinib with Radioiodinated IPHY in Lung Cancer. (2009)
  • Author(s): Yoshimoto M., Hirata M., Kawai K., et al
  • Organizer: The Society of Nuclear Medicine 56th Annual Meeting
  • Place of Presentation: Metro Toronto Convention Centre(Canada)
  • Year and Date: 2009-06-13
• [Presentation] Mechanism of Renal FDG Transcellular Transport and Cellular Accumulation using LLC-PK1 Cells. (2009)
  • Author(s): Kobayashi M., Araki H., Kawai K., et al
  • Organizer: The Society of Nuclear Medicine 56th Annual Meeting
  • Place of Presentation: Metro Toronto Convention Centre(Canada)
  • Year and Date: 2009-06-13
• [Presentation] Comparison of System A and System L Amino Acid Transports in Human Pancreas with C-11 MeAIB and C-11 MET PET Study. (2009)
  • Author(s): Nishii R., Kobayashi M., Kawai K., et al
  • Organizer: The Society of Nuclear Medicine 56th Annual Meeting
  • Place of Presentation: Metro Toronto Convention Centre(Canada)
  • Year and Date: 2009-06-13
• [Presentation] Measurement of Cerebral Oxygen Metabolism of Rats using Injectable O-15 Oxygen and Steady-state Method. (2009)
  • Author(s): Kobayashi M., Tiwari V.N., Kawai K., et al
  • Organizer: The Society of Nuclear Medicine 56th Annual Meeting
  • Place of Presentation: Metro Toronto Convention Centre(Canada)
  • Year and Date: 2009-06-13
• [Presentation] ビジュアルキネティクスによるターゲッティングコンファーマティヴ個別化医療 (2009)
  • Author(s): 川井恵一
  • Organizer: 第4回学際物質戦略イニシアチブバイオグループシンポジウム-可視化と治療-
  • Place of Presentation: 筑波大学東京キャンパス(東京都)
  • Year and Date: 2009-05-08
• [Book] 放射線双書「放射化学と放射線化学」(四訂版) (2012)
  • Author(s): 河村正一, 井上修, 荒野泰, 川井恵一
  • Total Pages: 255
  • Publisher: 通商産業研究社
• [Book] 「放射線関係法規概説-医療分野も含めて-」(第4版) (2011)
  • Author(s): 川井恵一
  • Total Pages: 205
  • Publisher: 通商産業研究社
• [Book] 「新放射化学・放射性医薬品学」(改訂第3版) (2011)
  • Author(s): 川井恵一, 他
  • Total Pages: 321
  • Publisher: 南江堂
• [Book] 放射線技術学シリーズ「放射線安全管理学」(改訂2版) (2011)
  • Author(s): 川井恵一, 他
  • Total Pages: 240
  • Publisher: オーム社
• [Book] 放射線関係法規概説-医療分野も含めて-(第4版) (2011)
  • Author(s): 川井恵一
  • Total Pages: 205
  • Publisher: 通商産業研究社
• [Book] 医用画像ハンドブック (2010)
  • Author(s): 川井恵一, 他
  • Total Pages: 1571
  • Publisher: オーム社
• [Book] 「放射線関係法規概説-医療分野も含めて-」(第3版) (2009)
  • Author(s): 川井恵一
  • Total Pages: 205
  • Publisher: 通商産業研究社
• [Remarks] 金沢大学研究紹介データベース
  • URL: http://kurt.kanazawa-u.ac.jp/souran_ku/info.php?teacher_id=488
• [Remarks] 金沢大学医薬保健研究域保健学系量子医療技術学講座川井研究室
  • URL: http://kawai.w3.kanazawa-u.ac.jp/index.html
• [Remarks] 金沢大学研究紹介データベース
  • URL: http://kurt.kanazawa-u.ac.jp/souran_ku/info.php?teacher_id=488
• [Remarks] 金沢大学医薬保健研究域保健学系量子医療技術学講座川井研究室
  • URL: http://kawai.w3.kanazawa-u.ac.jp/index.html
• [Remarks] 金沢大学研究紹介データベース
  • URL: http://kurt.kanazawa-u.ac.jp/souranku/info.php?teacherid=488
• [Remarks] 金沢大学医薬保健研究域保健学系 量子医療技術学講座 川井研究室
  • URL: http://kawai.w3.kanazawa-u.ac.jp/index.html
• [Remarks]
  • URL: http://kurt.kanazawa-u.ac.jp/souran_ku/info.php?teacher_id=488