Epigenetic regulation of glioma stem cell by using rho/mDia signaling
| Project/Area Number |
21659339
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyoto University |
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Principal Investigator |
ARAKAWA Yoshiki 京都大学, 大学院・医学研究科, 助教 (20378649)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,240,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2009: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | 悪性神経膠腫 / バイオイメージング / 腫瘍幹細胞 / エピジェネティクス / CD133 / エピジェネティック / グリオーマ / 分化誘導 / Rho / 接着因子 / FRET |
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| Research Abstract |
Cancer stem cells(CSC) reside in the specialized microenvironment"niche"and the cell differentiation of CSC is regulated in response to microenvironment changes. We studied the epigenetic regulation of glioma stem cell by using Rho/mDia signaling. By using inhibitors for Rho signaling, we found that rho signaling is involved in induction of differentiation of CSC. Our findings support that Rho/mDia signaling plays an important role in epigenetic regulation of CSC.
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Report
(4 results)
Research Products
(27 results)
