Elucidating the bone resorption mechanism using a glycobiological approach
| Project/Area Number |
21659346
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
IWASAKI Norimasa 北海道大学, 大学院・医学研究科, 准教授 (30322803)
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| Co-Investigator(Kenkyū-buntansha) |
ABE Yuichirou 北海道大学, 北海道大学病院, 助教 (80547604)
高畑 雅彦 北海道大学, 大学病院, 助教 (40374368)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,180,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2009: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | 骨吸収 / 破骨細胞 / 糖鎖 / ガングリオシド / 脂質ラフト / 糖脂質 / 糖鎖受容体 / レクチン / 細胞融合 / RANKL / シアリル糖鎖 / 骨代謝 / 糖蛋白質 |
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| Research Abstract |
We established expression profiles of N-linked glycans and glycosphingolipids during osteoclastogenesis. Among glycosphingolipids expressed on osteoclasts and these precursor cells, we identified GD1/ganglioside as a negative regulator of proliferation of osteoclast precursor cells.
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Report
(4 results)
Research Products
(5 results)
