The development of the bi-directional support system for the homecare patients by using Skype

• Project/Area Number: 21659529
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Community health/Gerontological nurisng
• Research Institution: Kyoto University
• Principal Investigator: KINOSHITA Ayae 京都大学, 医学研究科, 教授 (80321610)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,340,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥800,000 (Direct Cost: ¥800,000); Fiscal Year 2009: ¥1,500,000 (Direct Cost: ¥1,500,000)
• Keywords: IT / 在宅介護 / Skype / テレビカメラ / 認知症 / 在宅支援 / テレビ電話 / スカイプ

Research Abstract

We have been focusing on the usefulness of information technology(IT) as a tool to support the homecare patients of dementia and their caregivers. IT is often regarded as a"mere"technology in Japan. It is mainly used in tracking the wandering dementia patients using GPS system, however, its usefulness is not yet well understood in the field of clinical medicine. We believe that development of a new system which connects medical staff and homecare patients bi-directionally is a key to curb growing medical costs and increase the well-being of the patients and caregivers. In this research proposal, we utilized FletsPhone(by NTT West Japan) as an easy and portable TV phone. We performed the intervention program for dementia patients(Kyoto University Hospital) once a week for 3 months to check health status and give a rehabilitation program utilizing the touch panel system of FletsPhone. Although the cognitive score was not improved significantly compared to the control group, the score of PGC Moral Scale increased to some extent. The patients and caregivers showed great satisfaction about the intervention via TV camera. From this result we conclude that the intervention program using IT-based TV camera is effective to support homecare patients and caregivers. The cost-effectiveness was excellent and should be utilized in the field of clinical medicine widely.

Research Products

• [Journal Article] Gain of function by phosphorylation in Presenilin 1-mediated regulation of insulin signaling (2012)
  • Author(s): Maesako M, Uemura K, Kuzuya A, Sasaki K, Asada M, Watanabe K, Ando K, Kubota M, Akiyama H, Takahashi R, Kihara T, Shimohama S, Kinoshita A.
  • Journal Title: J Neurochem Volume: 121 Issue: 6 Pages: 964-973
  • DOI: 10.1111/j.1471-4159.2012.07741.x
  • Peer Reviewed
• [Journal Article] 産学連携による共同研究の取り組み & ICT機器の在宅医療への応用 (2011)
  • Author(s): 久保田正和、古家彩名、木下彩栄
  • Journal Title: 健康科学 Volume: Vol7 Pages: 81-86
  • NAID: 120004140450
  • Peer Reviewed
• [Journal Article] テレビ電話を用いた定期的な介入が糖尿病患者の血糖コントロールに与える影響 (2011)
  • Author(s): 久保田正和、細田公則、江口恭子、古家彩名、西嶋ゆき、中尾一和、木下彩栄
  • Journal Title: 癌と化学療法 Volume: 38 Pages: 97-99
• [Journal Article] Presenilin regulates insulin signaling viagamma-secretase independent mechanism (2011)
  • Author(s): Maesako M, Uemura K, Kuzuya A, Sasaki K, Asada M, Watanabe K, Ando K, Kubota M, Kihara T, Ayae Kinoshita
  • Journal Title: J Biol Chem Volume: 286 Pages: 25309-16
  • Peer Reviewed
• [Journal Article] Insightinto"synaptopathy"in Alzheimer' sdisease : From lifestyle to PS1/N-cadherininteraction. (2011)
  • Author(s): Kuzuya A, Kinoshita A, Uemura K.
  • Journal Title: Alz Dis Res J Volume: 3 Pages: 47-56
  • Peer Reviewed
• [Journal Article] N-cadherin regulates p38MAPK signaling via association with JNK-associated leucine zipper protein implications for neurodegeneration in Alzheimer disease (2011)
  • Author(s): Ando K, Uemura K, Kuzuya A, Maesako M, Asada-Utsugi M, Kubota M, Aoyagi N, Yoshioka K, Okawa K, Inoue H, Kawamata J, Shimohama S, Arai T, Takahashi R, Kinoshita A.
  • Journal Title: J Biol Chem Volume: 286 Pages: 7619-7628
  • Peer Reviewed
• [Journal Article] Effect of glycogensynthase kinase 3β-mediated presenilin 1phosphorylation on amyloidβproductionis negatively regulated by insulin receptor cleavage (2011)
  • Author(s): Maesako M, Uemura K, Kubota M, HiyoshiK, Ando K, Kuzuya A, Kihara T, Asada M, Akiyama H, Kinoshita A.
  • Journal Title: Neuroscience Volume: 177 Pages: 298-307
  • Peer Reviewed
• [Journal Article] 産学連携による共同研究の取り組みICT機器の在宅医療への応用 (2011)
  • Author(s): 久保田正和、古家彩名、木下彩栄
  • Journal Title: 健康科学 Volume: 11(in press)
  • NAID: 120004140450
  • Peer Reviewed
• [Journal Article] N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein : implications for neurodegeneration in Alzheimer disease (2011)
  • Author(s): Ando K, Uemura K, Kuzuya A, Maesako M, Asada-Utsugi M, Kubota M, Aoyagi N, Yoshioka K, Okawa K, Inoue H, Kawamata J, Shimohama S, Arai T, Takahashi R, Kinoshita A
  • Journal Title: Journal of Biological Chemistry Volume: 286 Pages: 7619-7628
  • Peer Reviewed
• [Journal Article] Effect of glycogen synthase kinase 3 β-mediated presenilin 1 phosphorylation on amyloid β production is negatively regulated by insulin receptor cleavage (2011)
  • Author(s): Maesako M, Uemura K, Kubota M, Hiyoshi K, Ando K, Kuzuya A, Kihara T, Asada M, Akiyama H, Kinoshita A
  • Journal Title: Neuroscience Volume: 177 Pages: 298-307
  • NAID: 120002970866
  • Peer Reviewed
• [Journal Article] Insight into "synaptopathy" in Alzheimer's disease (2011)
  • Author(s): Kuzuya A, Uemura K, Kinoshita A
  • Journal Title: Journal of Alzheimer's Disease Research Volume: (In press)
• [Journal Article] Insulin regulates Presenilin1 localization viaPI3K/Akt signaling (2010)
  • Author(s): Maesako M, Uemura K, Kubota M, Ando K, Kuzuya A, Kihara T, Kinoshita A.
  • Journal Title: Neurosci Lett. Volume: 483 Pages: 157-161
  • NAID: 120002484938
  • Peer Reviewed
• [Journal Article] Insulin regulates Presenilin 1 localization via PI3K/Akt signaling (2010)
  • Author(s): Maesako M, Uemura K, Kubota M, Ando K, Kuzuya A, Asada M, Kihara T, Kinoshita A
  • Journal Title: Neuroscience Letters Volume: 483 Pages: 157-161
  • NAID: 120002484938
  • Peer Reviewed
• [Journal Article] Blogging is an effective way to reduce a stress for caregivers who are involved in caring dementia patients at home--the result from the questionnaire survey (2010)
  • Author(s): Hori M, Kubota M, Kinoshita A
  • Journal Title: Gan to Kagaku Ryoho Volume: Supple 2 Pages: 192-194
• [Journal Article] The cleavage of N-cadherin is essential for chondrocyte differentiation (2010)
  • Author(s): Nakazora S, Matsumine A, Iino T, Hasegawa M, Kinoshita A, Uemura K, Niimi R, Uchida A, Sudo A
  • Journal Title: Biochem Biophys Res Commun Volume: 400 Pages: 493-499
  • Peer Reviewed
• [Journal Article] N-cadherin-based adhesion enhances Aβrelease and decrerased Aβ42/40 ratio (2009)
  • Author(s): Uemura K, Lill CM, Banks M, Aoyagi N, Ando, K., Kubota M, Kihara T, Nishimoto T, Sugimoto H, Takahashi R, Hyman BT, Shimohama S, Berezovska O, Kinoshita, A
  • Journal Title: J Neurochem Volume: 156 Pages: 350-360
  • Peer Reviewed
• [Journal Article] 在宅認知症高齢者とその家族介護者に対するテレビ電話システムを用いたコミュニケーションの有効性 (2009)
  • Author(s): 保利美也子、久保田正和、安藤功一、木原武士、高橋良輔、木下彩栄
  • Journal Title: 癌と化学療法 Volume: 36 Pages: 36-38
• [Journal Article] N-cadherin-based adhesion enhances Abeta release and decreased Abet a42/40 ratio (2009)
  • Author(s): Uemura K, Lill CM, Banks M, Aoyagi N, Ando K, Kubota M, Kihara T, Nishimoto T, Sugimoto H, Takahashi R, Hyman BT, Shimohama S, Kinoshita A
  • Journal Title: Journal of Neurochemistry 156 Pages: 350-360
  • Peer Reviewed
• [Journal Article] Chronic cerebral hypoperfusion accelerates amyloid beta deposition in APPSwedish transgenic mouse (2009)
  • Author(s): Kitaguchi H, Tomimoto H, Ihara M, Shibata M, Uemura K, Kalaria RN, Kihara T, Asada-Utsugi M, Kinoshita A, Takahashi R
  • Journal Title: Brain Research 1294 Pages: 202-210
  • Peer Reviewed
• [Journal Article] 在宅認知症高齢者とその家族介護者に対するテレビ電話システムを用いたコミュニケーションの有効性 (2009)
  • Author(s): 保利美也子, 久保田正和, 安藤功一, 木原武士, 高橋良輔, 木下彩栄
  • Journal Title: 癌と化学療法 36(Suppl) Pages: 36-38
• [Journal Article] (2009)
  • Author(s): 木下彩栄, 他
  • Journal Title: ガイドライン 外来診療 2009(日経メディカル開発) Pages: 395-402
• [Journal Article] (2009)
  • Author(s): 木下彩栄, 他
  • Journal Title: 外来診療ハンディガイド(日経メディカル開発) Pages: 200-203
• [Journal Article] Exercise is more effective than diet control in preventing high fat diet-inducedβ-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice
  • Author(s): Masato Maesako, Kengo Uemura, Masakazu Kubota, Akira Kuzuya, Kazuki Sasaki, Naoko Hayashida, Megumi Asada-Utsugi, Kiwamu Watanabe, Maiko Uemura, TakeshiKihara, Ryosuke Takahashi, Shun Shimohama and Ayae Kinoshita
  • Journal Title: The Journal of Biological Chemistry
  • Peer Reviewed
• [Journal Article] Environmental enrichment ameliorated high fat diet-induced Aβdeposition and memory deficit in APP transgenic mice
  • Author(s): Maesako M, Uemura K, Kubota M, Kuzuya A, Sasaki K, Asada M, Watanabe K, Hayashida N, Ihara M, Ito H, Kihara T, Kinoshita A.
  • Journal Title: Neurobiology of Aging
  • NAID: 120003988394
  • Peer Reviewed
• [Journal Article] N-cadherin enhances APP dimerization at the extra cellular domain and modulates A beta production
  • Author(s): Asada-Utsugi M, Uemura K, Noda Y, Kuzuya A, Maesako M, Ando K, Kubota M, Watanabe K, Takahashi M, Kihara T, Shimohama S, Takahashi R, Berezovska O, Kinoshita A.
  • Journal Title: J Neurochem
  • Peer Reviewed
• [Presentation] アルツハイマー病の最前線 (2011)
  • Author(s): 木下彩栄
  • Organizer: 福知山医師会
  • Place of Presentation: 福知山医師会(招待講演)
  • Year and Date: 2011-11-19
• [Presentation] ITを利用した在宅支援の取り組み (2011)
  • Author(s): 木下彩栄
  • Organizer: 乙訓郡医師会
  • Place of Presentation: 乙訓郡医師会(招待講演)
  • Year and Date: 2011-10-29
• [Presentation] テレビ電話を用いた定期的な介入が糖尿病患者の血糖コントロールに与える影響 (2011)
  • Author(s): 久保田正和、細田公則、江口恭子、古家彩名、西嶋ゆき、中尾一和、木下彩栄
  • Organizer: 日本在宅医療学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-06-29
• [Presentation] テレビ電話を用いた定期的な介入が糖尿病患者の血糖コントロールに与える影響 (2011)
  • Author(s): 久保田正和、細田公則、江口恭子、古家彩名、西嶋ゆき、中尾一和、木下彩栄
  • Organizer: 日本在宅医療学会学術集会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-06-29
• [Presentation] アルツハイマー病の最前線 (2011)
  • Author(s): 木下彩栄
  • Organizer: 福知山医師会招待講演
• [Presentation] ITを利用した在宅支援のとりくみ乙訓郡 (2011)
  • Author(s): 木下彩栄
  • Organizer: 医師会招待講演
• [Presentation] ITを利用した双方向性コミュニケーションによる患者支援システム (2010)
  • Author(s): 古家彩名、保利美也子、久保田正和、武地一、木下彩栄
  • Organizer: 日本認知症ケア学会
  • Place of Presentation: 神戸
• [Presentation] APPシスダイマー化におけるN-cadherin、ネクチン1の影響 (2010)
  • Author(s): 浅田めぐみ、植村健吾、葛谷聡、山田奈央、前迫真人、安藤功一、渡辺究、久保田正和、Oksana Berezovska, Brad Hyman, 下浜俊、高橋良輔、木下彩栄
  • Organizer: 神経科学会
  • Place of Presentation: 神戸
• [Presentation] Effects of Presenilin 1 phosphorylation on Insulin Receptor (2010)
  • Author(s): 前迫真人、植村健吾、久保田正和、安藤功一、葛谷聡、山田奈央、浅田めぐみ、秋山治彦、木下彩栄
  • Organizer: 神経科学会
  • Place of Presentation: 神戸
• [Presentation] インスリンシグナルがPS1に与える影響の解明 (2010)
  • Author(s): 前迫真人、植村健吾、佐々木和樹、安藤功一、葛谷聡、浅田めぐみ、久保田正和、秋山治彦、木下彩栄
  • Organizer: 日本認知症学会
  • Place of Presentation: 名古屋
• [Presentation] インスリンシグナルがプレセニリンの局在・機能に与える影響の解明 (2010)
  • Author(s): 木下彩栄、前迫真人、浅田めぐみ、葛容聡、安藤功一、久保田正和、植村健吾、秋山治彦
  • Organizer: 日本神経学会総会
  • Place of Presentation: 東京
• [Presentation] Analysis of N-cadherin interacting proteins in Alzheimer's disease (2010)
  • Author(s): Koichi A, Maesako M, Asada M, Aoyagi N, Kubota M, Kuzuya A, Uemura K, Kawamata J, Takahashi R, Kinoshita A
  • Organizer: International Conference of Alzheimer's disease
  • Place of Presentation: 米国ハワイ州ホノルル
• [Presentation] Presenilin1, a causative gene for Alzheimer's disease, is regulated by insulin signaling (2010)
  • Author(s): Kinoshita A
  • Organizer: International Conference for Alzheimer's disease(Peking University)
  • Place of Presentation: 中国北京市
• [Presentation] 認知症の病態とケア (2009)
  • Author(s): 木下彩栄
  • Organizer: 聖母女学院短期大学特別講演
  • Place of Presentation: 京都
• [Presentation] 認知症高齢者の身体合併症に対する一般病院の対応 (2009)
  • Author(s): 江口恭子、木下彩栄
  • Organizer: 認知症ケア学会
  • Place of Presentation: 東京
• [Presentation] 認知症患者の尊厳死に対する意識調査 (2009)
  • Author(s): 古家彩名、久保田正和、木下彩栄
  • Organizer: 認知症ケア学会
  • Place of Presentation: 東京
• [Presentation] 在宅要介護高齢者を介護する家族主介護者の結婚満足度と介護要因の検討 (2009)
  • Author(s): 日吉和子、カール・ベッカー、木下彩栄
  • Organizer: 日本在宅医療学会
  • Place of Presentation: 東京
• [Presentation] 在宅認知症高齢者とその家族介護者に対するテレビ電話システムを用いたコミュニケーションの有効性 (2009)
  • Author(s): 保利美也子、久保田正和、安藤功一、木原武士、高橋良輔、木下彩栄
  • Organizer: 日本在宅医療学会
  • Place of Presentation: 東京
• [Presentation] IT利用が在宅介護者の介護ストレスに与える影響 (2009)
  • Author(s): 久保田正和、保利美也子、宋慶華、日吉和子、木下彩栄
  • Organizer: 日本老年看護学会
  • Place of Presentation: 横浜
• [Presentation] 認知症の病態とケア (2009)
  • Author(s): 木下彩栄
  • Organizer: 聖母女学院短期大学特別講演
  • Place of Presentation: 聖母女学院短期大学
• [Presentation] 認知症の病態と治療の現状 (2009)
  • Author(s): 木下彩栄
  • Organizer: 日本作業療法士協会専門作業療法士取得研修
  • Place of Presentation: 京都大学
• [Presentation] APPダイマー化に対するN-カドヘリンの影響 (2009)
  • Author(s): 浅田めぐみ, 植村健吾, 葛谷聡, 久保田正和, 下浜俊, 高橋良輔, 木下彩栄
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] アルツハイマー病におけるN-カドヘリン関連たんぱく質の解析 (2009)
  • Author(s): 安藤功一, 前迫真人, 浅田めぐみ, 久保田正和, 青柳信寿, 植村健吾, 葛谷聡, 川又純, 高橋良輔, 木下彩栄
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] インスリンシグナルを介したプレセニリン1の機能制御 (2009)
  • Author(s): 前迫真人, 植村健吾, 久保田正和, 青柳信寿, 葛谷聡, 安藤功一, 池内健, 浅田めぐみ, 木下彩栄
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] APPダイマー化におけるN-カドヘリンの影響 (2009)
  • Author(s): 浅田めぐみ, 植村健吾, 葛谷聡, 渡辺拡人, 久保田正和, 下濱俊, 高橋良輔, 木下彩栄
  • Organizer: 日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] 細胞内たんぱく質分解系がPS1によるAPPの切断に及ぼす影響の検討 (2009)
  • Author(s): 渡辺拡人, 葛谷聡, 浅田めぐみ, 植村健吾, 渡辺拡人, 前迫真人, 久保田正和, 高橋良輔, 木下彩栄
  • Organizer: 日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] プレセニリンのリン酸化がインスリン受容体の切断に与える影響 (2009)
  • Author(s): 前迫真人, 植村健吾, 久保田正和, 安藤功一, 葛谷聡, 浅田めぐみ, 渡辺拡人, 山田奈央, 秋山治彦, 木下彩栄
  • Organizer: 日本分子生物学会
  • Place of Presentation: 横浜
• [Remarks] ホームページ等京都大学大学院医学研究科在宅医療看護学分野木下研究室
  • URL: http://hs.med.kyoto-u.ac.jp/kinoshita-lab/index.html