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Development of an novel method for studying relationships between neural circuits and behaviors using optogenetic approaches.

Research Project

Project/Area Number 21680028
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Neuroscience in general
Research InstitutionNational Institute for Basic Biology

Principal Investigator

HIYAMA Takeshi  National Institute for Basic Biology, 統合神経生物学研究部門, 助教 (90360338)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Fiscal Year 2010: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2009: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Keywords光活性化型チャンネル / 神経科学 / 生理学 / 生物物理 / 光スイッチ / 行動学
Research Abstract

The purpose of this research is development of a new method for studying the relationship of neural circuit and behaviors using light-activated channels and pumps. We developed a new system for optical stimulation of free-moving animals with optical fiber coupled to lasers. Using this system and a transgenic mice expressing KikGR, a photomodulatable fluorescent protein, we estimated the size of illuminated area in free-moving mice.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (20 results)

All 2010 2009 Other

All Journal Article (7 results) (of which Peer Reviewed: 4 results) Presentation (5 results) Book (1 results) Remarks (7 results)

  • [Journal Article] Autoimmunity to the sodium-level sensor in the brain causes essential hypernatremia.2010

    • Author(s)
      Hiyama TY, Matsuda S, Fujikawa A, Matsumoto M, Watanabe E, Kajiwara H, Niimura F, Noda M.
    • Journal Title

      Neuron 66

      Pages: 508-522

    • NAID

      40017363776

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Na_xに対する自己抗体の産生が本態性高Na血症の原因となる2010

    • Author(s)
      檜山武史, 野田昌晴
    • Journal Title

      細胞工学 29(11)

      Pages: 1132-1138

    • Related Report
      2010 Final Research Report
  • [Journal Article] Nax-deficient mice show normal vasopressin response to dehydration.2010

    • Author(s)
      Nagakura A, Hiyama TY, Noda M.
    • Journal Title

      Neuroscience Letters 472

      Pages: 161-165

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autoimmunity to the sodium-level sensor in the brain causes essential hypernatremia.2010

    • Author(s)
      Hiyama TY, Matsuda S, Fujikawa A, Matsumoto M, Watanabe E, Kajiwara H, Niimura F, Noda M.
    • Journal Title

      Neuron.

      Volume: 66 Pages: 508-522

    • NAID

      40017363776

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Na_xに対する自己抗体の産生が本態性高Na血症の原因となる2010

    • Author(s)
      檜山武史、野田昌晴
    • Journal Title

      細胞工学

      Volume: 29 Pages: 1132-1138

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Na_x-deficient mice show normal vasopressin response to dehydration2010

    • Author(s)
      Nagakura A, Hiyama TY, Noda M.
    • Journal Title

      Neurosci Lett. 473

      Pages: 161-165

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 化学受容から行動までの情報ハイウエイ-4 脳のナトリウムセンサー2009

    • Author(s)
      檜山武史, 渡辺英治, 野田昌晴
    • Journal Title

      日本味と匂学会誌 16

      Pages: 133-140

    • Related Report
      2010 Final Research Report
  • [Presentation] Autoimmunity to the sodium-level sensor in the brain causes essential hypernatremia2010

    • Author(s)
      Hiyama TY, Matsuda S, Fujikawa A, Matsumoto M, Watanabe E, Kajiwara H, Niimura F, Noda M.
    • Organizer
      BMB2010
    • Place of Presentation
      神戸コンベンションセンター(神戸市)
    • Year and Date
      2010-12-10
    • Related Report
      2010 Final Research Report
  • [Presentation] 脳の体液NaレベルセンサーNa_xに対する自己抗体の産生が本態性高Na血症の原因となる2010

    • Author(s)
      檜山武史、松田晋一、藤川顕寛、松本匡史、渡辺英治、梶原博、新村文男、野田昌晴
    • Organizer
      第33回日本分子生物学会年会(BMB2010)
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 体液塩濃度の恒常性:脳で感じるNa濃度2010

    • Author(s)
      檜山武史
    • Organizer
      第7回コンビナトリアル・バイオエンジニアリング会議「感覚の不思議をはかるために」
    • Place of Presentation
      千里阪急ホテル(吹田市)
    • Year and Date
      2010-11-12
    • Related Report
      2010 Final Research Report
  • [Presentation] Autoimmunity to the sodium-level sensor in the brain causes essential hypernatremia2010

    • Author(s)
      Hiyama TY, Matsuda S, Fujikawa A, Matsumoto M, Watanabe E, Kajiwara H, Niimura F, Noda M.
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸コンベンションセンター(神戸市)
    • Year and Date
      2010-09-04
    • Related Report
      2010 Final Research Report
  • [Presentation] 脳の体液NaレベルセンサーNa_xに対する自己抗体の産生が本態性高Na血症の原因となる2010

    • Author(s)
      檜山武史、松田晋一、藤川顕寛、松本匡史、渡辺英治、梶原博、新村文男、野田昌晴
    • Organizer
      第33回日本神経科学大会(Neuro2010)
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Book] トランスポートソームの世界-膜輸送研究の源流から未来へ-(金井好克, 竹島浩, 森泰生, 久保義弘編)(その他の生体内センサーチャネル)2010

    • Author(s)
      檜山武史, 野田昌晴
    • Publisher
      京都廣川書店
    • Related Report
      2010 Final Research Report
  • [Remarks] 新聞報道等

    • Related Report
      2010 Final Research Report
  • [Remarks] 2010/05/27 日経産業新聞「原因不明「高ナトリウム血症」 免疫異常が関与基礎生物研など解明」

    • Related Report
      2010 Final Research Report
  • [Remarks] 2010/05/27 日経プレスリリース「基礎生物学研究所、高ナトリウム血症の発症機構を解明原因不明だった高ナトリウム血症の発症機構を解明~脳の体液Naレベルセンサーに対する抗体が産生される自己免疫疾患だった~」

    • Related Report
      2010 Final Research Report
  • [Remarks] Web報道

    • Related Report
      2010 Final Research Report
  • [Remarks] 2010/06/17 Faculty of 1000 "Must Read Paper" by Angela Vincent (University of Oxford, UK)

    • Related Report
      2010 Final Research Report
  • [Remarks] 2010/05/27 Neuron誌トップページ"Featured Case Study"

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.nibb.ac.jp/press/100527/100527.html

    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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