| Budget Amount *help |
¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2009: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Research Abstract |
We investigated the structure and functions of paralytic neurotoxins from terrestrial venomous mammals. A neurotoxin (5 kDa) was almost purified from the salivary gland extracts of the short-tailed shrew Blarina brevicauda. From the venom fluidof the duck-bill platypus Ornithorhynchus anatinus, 11 unique neurotoxins, including a heptapeptide HDHPNPR, were identified and their biological activities have beencharacterized. We also established that platypus venom contains kallikrein-type protease(s), as with reptilian and shrew venom. The present findings may lead to the development of valuable pain-relief or vasoactive substances.
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