| Budget Amount *help |
¥26,910,000 (Direct Cost: ¥20,700,000、Indirect Cost: ¥6,210,000)
Fiscal Year 2011: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2010: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2009: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Research Abstract |
RNAi is currently an important experimental tool for basic research into gene function. RNAi also has many potential uses in various biotechnological and therapeutic applications. We recently developed photoinducible RNAi method, termed CLIP-RNAi. In this study, we improved the photoresponsive RNA carrier for CLIP-RNAi. We demonstrate the use of CLIP-RNAi with several fluorescent dyes that can be excited at different wavelengths. We used CLIP-RNAi method in in vitro and in vivo applications.
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