The analysis of antigen presenting cells in mouse and human intestinal lamina propria
Project/Area Number |
21689015
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Immunology
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Research Institution | Osaka University |
Principal Investigator |
UEMATSU Satoshi 大阪大学, 免疫学フロンティア研究センター, 特任准教授 (50379088)
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Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥27,560,000 (Direct Cost: ¥21,200,000、Indirect Cost: ¥6,360,000)
Fiscal Year 2011: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2010: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2009: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
|
Keywords | Toll-like receptor / マクロファージ / 樹状細胞 / 腸管粘膜固有層 / 自然免疫 / IgA / Th応答 / CTL / 樹上細胞 |
Research Abstract |
We found that CD103^+ DC in small intestine are divided into two subsets according to CD8αexpression. CD103^+ CD8α^+ DC express TLR3, 7 and 9 and induced Th1 response and Ag-specific IgG. In contrast, CD103^+ CD8α^+ DC express TLR5 and 9 and induced Th1 and Th17 responses, Ag-specific IgG and IgA and strong CTL activity. Accordingly, CD103^+ CD8α^+ LPDCs have the different function in active immunity from CD103^+ CD8α^-LPDCs.
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Report
(4 results)
Research Products
(98 results)
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[Journal Article] A new subset of CD103^+ CD8a^+ DCs in the small intestine express TLR3, TLR7 and TLR9, and induce Th1 response and CTL activity2011
Author(s)
Fujimoto K, Karuppuchamy T, Takemura N, Shimohigoshi M, Machida T, Haseda Y, Aoshi T, Ishii KJ, Akira S, Uematsu S
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Journal Title
J Immunol
Volume: 186(11)
Pages: 6287-95
Related Report
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[Journal Article] Plasmacytoid Dendritic Cells Promote Host Defense against Acute Pneumovirus Infection via the TLR7-MyD88-Dependent Signaling Pathway2011
Author(s)
Davidson S, Kaiko G, Loh Z, Lalwani A, Zhang V, Spann K, Foo SY, Hansbro N, Uematsu S, Akira S, Matthaei KI, Rosenberg HF, Foster PS, Phipps S
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Journal Title
J Immunol
Volume: 186(10)
Pages: 5938-48
Related Report
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[Journal Article] Antigen-Specific T-Cell Responses to a Recombinant Fowlpox Virus Are Dependent on MyD88 and Interleukin-18 and Independent of Toll-Like Receptor 7(TLR7)-and TLR9-Mediated Innate Immune Recognition2011
Author(s)
Lousberg EL, Diener KR, Fraser CK, Phipps S, Foster PS, Chen W, Uematsu S, Akira S, Robertson SA, Brown MP, Hayball JD
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Journal Title
J Virol
Volume: 85(7)
Pages: 3385-96
Related Report
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[Journal Article] Airway epithelial indoleamine 2,3-dioxygenase inhibits CD4+ T cells during Aspergillus fumigatus antigen exposure.2011
Author(s)
Paveglio SA, Allard J, Foster Hodgkins SR, Ather JL, Bevelander M, Campbell JM, Whittaker Le Clair LA, McCarthy SM, van der Vliet A, Suratt BT, Boyson JE, Uematsu S, Akira S, Poynter ME.
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Journal Title
Am J Respir Cell Mol Biol.
Volume: 44(1)
Pages: 11-23
Related Report
Peer Reviewed
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[Journal Article] Role of microsomal prostaglandin E synthase-1 in the facilitation of angiogenesis and the healing of gastric ulcers2010
Author(s)
Ae T, Ohno T, Hattori Y, Suzuki T, Hosono K, Minamino T, Sato T, Uematsu S, Akira S, Koizumi W, Majima M
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Journal Title
Am J Physiol Gastrointest Liver Physiol
Volume: 299(5)
Related Report
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[Journal Article] Toll-like receptor 4(TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia2010
Author(s)
Hyakkoku K, Hamanaka J, Tsuruma K, Shimazawa M, Tanaka H, Uematsu S, Akira S, Inagaki N, Nagai H, Hara H
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Journal Title
Neuroscience
Volume: 171(1)
Pages: 258-67
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[Journal Article] Pathways regulating cytosolic phospholipase A2 activation and eicosanoid production in macrophages by Candida albicans2010
Author(s)
Suram S, Gangelhoff TA, Taylor PR, Rosas M, Brown GD, Bonventre JV, Akira S, Uematsu S, Williams DL, Murphy RC, Leslie CC
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Journal Title
J Biol Chem
Volume: 285(40)
Pages: 30676-85
Related Report
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[Journal Article] mPGES-1-expressing bone marrow-derived cells enhance tumor growth and angiogenesis in mice2010
Author(s)
Kamata H, Hosono K, Suzuki T, Ogawa Y, Kubo H, Katoh H, Ito Y, Uematsu S, Akira S, Watanabe M, Majima M
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Journal Title
Biomed Pharmacother
Volume: 64(6)
Pages: 409-16
Related Report
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[Journal Article] Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/ nucleotide-binding oligomerization domain-mediated NF-kappa B signaling2010
Author(s)
Toma C, Higa N, Koizumi Y, Nakasone N, Ogura Y, McCoy AJ, Franchi L, Uematsu S, Sagara J, Taniguchi S, Tsutsui H, Akira S, Tschopp J, Nunez G, Suzuki T
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Journal Title
J Immunol
Volume: 184(9)
Pages: 5287-97
Related Report
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[Journal Article] Airway Epithelial Indoleamine 2, 3-Dioxygenase Inhibits CD4+ T Cells During Aspergillus fumigatus Antigen Exposure2010
Author(s)
Paveglio SA, Allard J, Foster Hodgkins SR, Ather J, Bevelander M, Mayette Campbell J, Whittaker Leclair LA, McCarthy SM, van der Vliet A, Suratt BT, Boyson JE, Uematsu S, Akira S, Poynter ME
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Journal Title
Am J Respir Cell Mol Biol
Related Report
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[Journal Article] Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappa Bsignaling.2010
Author(s)
Toma C, Higa N, Koizumi Y, Nakasone N, Ogura Y, McCoy AJ, Franchi L, Uematsu S, Sagara J, Taniguchi S, Tsutsui H, Akira S, Tschopp J, Nunez G, Suzuki T.
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Journal Title
J Immunol.
Volume: 184(9)
Pages: 287-297
Related Report
Peer Reviewed
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[Journal Article] mPGES-1-expressing bone marrow-derived cells enhance tumor growth and angiogenesis in mice.2010
Author(s)
Kamata H, Hosono K, Suzuki T, Ogawa Y, Kubo H, Katoh H, Ito Y, Uematsu S, Akira S, Watanabe M, Majima M.
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Journal Title
Biomed Pharmacother.
Volume: 4(6)
Pages: 409-416
Related Report
Peer Reviewed
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[Journal Article] Pathways regulating cytosolic phospholipase A2 activation and eicosanoid production in macrophages by Candida albicans.2010
Author(s)
Suram S, Gangelhoff TA, Taylor PR, Rosas M, Brown GD, Bonventre JV, Akira S, Uematsu S, Williams DL, Murphy RC, Leslie CC.
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Journal Title
J Biol Chem.
Volume: 285(40)
Pages: 30676-30685
Related Report
Peer Reviewed
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[Journal Article] Role of microsomal prostaglandin E synthase-1 in the facilitation of angiogenesis and the healing of gastric ulcers.2010
Author(s)
Ae T, Ohno T, Hattori Y, Suzuki T, Hosono K, Minamino T, Sato T, Uematsu S, Akira S, Koizumi W, Majima M.
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Journal Title
Am J Physiol Gastrointest Liver Physiol.
Volume: 299(5)
Related Report
Peer Reviewed
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[Journal Article] Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis2009
Author(s)
Kamei D, Murakami M, Sasaki Y, Nakatani Y, Majima M, Ishikawa Y, Ishii T, Uematsu S, Akira S, Hara S, Kudo I
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Journal Title
Biochem J
Volume: 425(2)
Pages: 361-71
Related Report
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[Journal Article] NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection2009
Author(s)
Kayama H, Koga R, Atarashi K, Okuyama M, Kimura T, Mak TW, Uematsu S, Akira S, Takayanagi H, Honda K, Yamamoto M, Takeda K
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Journal Title
Related Report
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[Journal Article] Baculovirus induces type I interferon production through toll-like receptor-dependent and-independent pathways in a cell-type-specific manner2009
Author(s)
Abe T, Kaname Y, Wen X, Tani H, Moriishi K, Uematsu S, Takeuchi O, Ishii KJ, Kawai T, Akira S, Matsuura Y
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Journal Title
J Virol
Volume: 83(15)
Pages: 7629-40
Related Report
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[Journal Article] Radioresistant cells expressing TLR5 control the respiratory epithelium' s innate immune responses to flagellin2009
Author(s)
Janot L, Sirard JC, Secher T, Noulin N, Fick L, Akira S, Uematsu S, Didierlaurent A, Hussell T, Ryffel B, Erard F
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Journal Title
Eur J Immunol
Volume: 39(6)
Pages: 1587-96
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