Analysis of vaccinia virus induced oncolytic bioresponse and bioimaging in malignant glioma
| Project/Area Number |
21689039
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyoto University |
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Principal Investigator |
ARAKAWA Yoshiki 京都大学, 大学院・医学研究科, 助教 (20378649)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥22,230,000 (Direct Cost: ¥17,100,000、Indirect Cost: ¥5,130,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2009: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
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| Keywords | 悪性神経膠腫 / ウイルス治療 / ワクシニアウイルス / バイオイメージング / 種痘ウイルス / がん / グリオーマ / Rho / Ras / がん免疫 |
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| Research Abstract |
To develop the new treatment strategy, I have analyzed vaccinia virus induced oncolytic bioresponse and bioimaging in malignant glioma. We found that modifications of cell signaling enhanced the oncolytic effect in glioma cells. In vivo studies with rat glioma model, the mechanism of viral anti-tumor effect are immunological response as well as oncolytic effect.
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Report
(4 results)
Research Products
(26 results)
