Search for genes and neural circuits involved in medaka interindividual interaction.

• Project/Area Number: 21700341
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: The University of Tokyo
• Principal Investigator: TAKEUCHI Hideaki The University of Tokyo, 大学院・理学系研究科, 助教 (00376534)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: メダカ / 社会性行動 / 条件的遺伝子操作法 / 初期応答遺伝子 / アデノウイルス / 神経新生 / 群れ行動 / 視運動反応 / 神経ペプチド / 脳 / 終脳 / サブスタンスP

Research Abstract

We established a behavioral system to induce medaka coordinated movements. Furthermore we established a method for the conditional gene manipulation in the medaka brain and identified some genes encoding neuropeptides as candidate genes involved in medaka social behavior.

Research Products

• [Journal Article] Induction of c-fos transcription in the medaka brain (Oryzias latipes) in response to mating stimuli. (2011)
  • Author(s): Okuyama T, Suehiro Y, Imada H, Shimada A, Naruse K, Takeda H, Kubo T, Takeuchi H
  • Journal Title: Biochem.Biophys.Res.Commun. 404 Pages: 453-457
• [Journal Article] Induction of c-fos transcription in the medaka brain (Oryzias latipes) in response to mating stimuli. (2011)
  • Author(s): Okuyama T, Suehiro Y, Imada H, Shimada A, Naruse K, Takeda H, Kubo T, Takeuchi H
  • Journal Title: Biochemical and biophysical research communications Volume: 404 Pages: 453-457
  • Peer Reviewed
• [Journal Article] Transient and permanent gene transfer into the brain of the teleost fish medaka (Oryzias latipes) using human adenovirus and the Cre-loxP system. (2010)
  • Author(s): Suehiro Y, Kinoshita M, Okuyama T, Shimada A, Naruse K, Takeda H, Kubo T, Hashimoto M, Takeuchi H
  • Journal Title: FEBS lett. 584 Pages: 3545-3549
• [Journal Article] Coordinated and Cohesive Movement of Two Small Conspecific Fish Induced by Eliciting a Simultaneous Optomotor Response. (2010)
  • Author(s): Imada H, Hoki M, Suehiro Y, Okuyama T, Kurabayashi D, Shimada A, Naruse K, Takeda H, Kubo T, Takeuchi H
  • Journal Title: PLoS ONE 5
• [Journal Article] Proliferation zones in adult medaka (Oryzias latipes) brain. (2010)
  • Author(s): Kuroyanagi Y, Okuyama T, Suehiro Y, Imada H, Shimada A, Naruse K, Takeda H, Kubo T, Takeuchi H
  • Journal Title: Brain Res. 1323 Pages: 33-40
• [Journal Article] Transient and permanent gene transfer into the brain of the teleost fish medaka (Oryzias latipes) using human adenovirus and the Cre-loxP system (2010)
  • Author(s): Suehiro Y, Kinoshita M, Okuyama T, Shimada A, Naruse K, Takeda H, Kubo T, Hashimoto M, Takeuchi H
  • Journal Title: FEBS letters Volume: 584 Pages: 3545-3549
  • Peer Reviewed
• [Journal Article] Coordinated and Cohesive Movement of Two Small Conspecific Fish Induced by Eliciting a Simultaneous Optomotor Response (2010)
  • Author(s): Imada H, Hoki M, Suehiro Y, Okuyama T, Kurabayashi D, Shimada A, Naruse K, Takeda H, Kubo T, Takeuchi H
  • Journal Title: PLoS ONE Volume: 5
  • Peer Reviewed
• [Journal Article] Proliferation zones in adult medaka (Oryzias latipes) brain. (2010)
  • Author(s): Kuroyanagi Y, Okuyama T, Suehiro Y, Imada H, Shimada A, Naruse K, Takeda H, Kubo T, Takeuchi H
  • Journal Title: Brain Research Volume: 1323 Pages: 33-40
  • Peer Reviewed
• [Journal Article] Mass spectrometric map of neuropeptide expression and analysis of the gamma-prepro-tachykinin gene expression in the medaka (Oryzias latipes) brain. (2009)
  • Author(s): Suehiro Y, Yasuda A, Okuyama, Imada H, Kuroyanagi, Y, Kubo T, Takeuchi H
  • Journal Title: Gen.Comp.Endocrinol. 161 Pages: 138-145
• [Journal Article] Mass spectrometric map of neuropeptide expression and analysis of the gamma-prepro-tachykinin gene expression in the medaka (Oryzias latipes) brain. (2009)
  • Author(s): Suehiro Y, Yasuda A, Okuyama T, Imada H, Kuroyanagi Y, Kubo T, Takeuchi H
  • Journal Title: General and Comparative Endocrinology Volume: 161 Pages: 138-145
  • Peer Reviewed
• [Journal Article] Analysis of Schooling-like Behavior of Medaka Fish and Identification of a Telencephalon-and-Hypothalamus-Preferential Gene in the Medaka Brain (2009)
  • Author(s): Haruka Imada, Yuji Suehiro, Teruhiro Okuyama, Daisuke Kurabayashi, Atsuko Shimada, Kiyoshi Naruse, Hiroyuki Takeda, Takeo Kubo, Hideaki Takeuchi
  • Journal Title: Proceeding of the Third International Symposium on Mobiligence Pages: 295-298
  • Peer Reviewed
• [Journal Article] Analysis of neural mechanism for the optomotor response of the medaka fish (2009)
  • Author(s): Yuji Suehiro, Teruhiro Okuyama, Haruka Imada, Kiyoshi Naruse, Daisuke Kurabayashi Atsuko Shimada, Hiroyuki Takeda Takeo Kubo, Hideaki Takeuchi
  • Journal Title: Proceeding of the Third International Symposium on Mobiligence Pages: 308-311
  • Peer Reviewed
• [Presentation] メダカ脳におけるアデノウィルスを用いた条件的遺伝子操作法 (2010)
  • Author(s): 末廣勇司、木下政人、奥山輝大、今田はるか、島田敦子、成瀬清、武田洋幸、橋本光広、久保健雄、竹内秀明
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-07
• [Presentation] Analysis of neural mechanism for mate guarding behavior (2010)
  • Author(s): 横井佐織、奥山輝大、竹内秀明、久保健雄
  • Organizer: 第33回日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-07
• [Presentation] Identification of medaka mutants with a defect in female mating acceptance depending on visual information (2010)
  • Author(s): 奥山輝大、末廣勇司、今田はるか、阿部秀樹、田中実、島田敦子、成瀬清、武田洋幸、岡良隆、久保健雄、竹内秀明
  • Organizer: 第33回日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-07
• [Presentation] Identification of medaka mutants with a defect in female mating acceptance depending on visual information (2010)
  • Author(s): Teruhiro Okuyama, Yuji Suehiro, Haruka Imada, Hideki Abe, Atsuko Shimada, Minoru Tanaka, Kiyoshi Naruse, Hiroyuki Takeda, Yoshitaka Oka, Takeo Kubo, Hideaki Takeuchi
  • Organizer: 日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-07
• [Presentation] Analysis of neural mechanism for mate guarding behavior (2010)
  • Author(s): 横井佐織、奥山輝大、竹内秀明、久保健雄
  • Organizer: 日本分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 2010-12-07
• [Presentation] メダカ脳におけるアデノウィルスを用いた条件的遺伝子操作法 (2010)
  • Author(s): 末廣勇司、木下政人、奥山輝大、今田はるか、島田敦子、成瀬清、武田洋幸、橋本光広、久保健雄、竹内秀明
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-07
• [Presentation] Identification of medaka mutants with a defect in Identification of medaka mutants with a defect in female mating acceptance depending on visual female mating acceptance depending on visual information information (2010)
  • Author(s): Teruhiro Okuyama, Yuji Suehiro, Haruka Imada, Atsuko Shimada, Minoru Tanaka, Kiyoshi Naruse, Hiroyuki Takeda, Takeo Kubo, Hideaki Takeuchi
  • Organizer: Society for Neuroscience meeting
  • Place of Presentation: サンディエゴ、米国
  • Year and Date: 2010-11-16
• [Presentation] Identification of medaka mutants with a defect in female mating acceptance depending on visual female mating acceptance depending on visual information (2010)
  • Author(s): Okuyama, T., Suehiro, Y., Imada, H., Tanaka, M., Shimada, A., Naruse, K., Takeda, H., Kubo, T., Takeuchi, H.
  • Organizer: The 40th annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego
  • Year and Date: 2010-11-15
• [Presentation] Gene transfer into the brain of the teleost fish medaka (Oryzias latipes) using human adenovirus and the Cre-loxP system (2010)
  • Author(s): Suehiro, Y., Kinoshita, M., Okuyama, T., Shimada, A., Naruse, K., Takeda, H., Kubo, T., Hashimoto, M., Takeuchi, H.
  • Organizer: The 40th annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego
  • Year and Date: 2010-11-15
• [Presentation] Gene transfor into the brain of the teleost fish medaka (Oryzias latipes, using human adenovirus and the Cre-loxP system (2010)
  • Author(s): Suehiro Y, Kinoshita M, Okuyama T, Shimada A, Naruse K, Takeda H, Kubo T, Hashimoto M, Takeuchi H
  • Organizer: Society for Neuroscience meeting
  • Place of Presentation: サンディエゴ、米国
  • Year and Date: 2010-11-15
• [Presentation] メダカ脳におけるアデノウィルスを用いた条件的遺伝子操作法 (2010)
  • Author(s): 末廣勇司、木下政人、奥山輝大、今田はるか、島田敦子、成瀬清、武田洋幸、橋本光広、久保健雄、竹内秀明
  • Organizer: 日本動物学会第81回大会
  • Place of Presentation: 東京
  • Year and Date: 2010-09-23
• [Presentation] メダカ脳におけるアデノウィルスを用いた条件的遺伝子操作法 (2010)
  • Author(s): 末廣勇司、木下政人、奥山輝大、今田はるか、島田敦子、成瀬清、武田洋幸、橋本光広、久保健雄、竹内秀明
  • Organizer: 日本動物学会第81回大会
  • Place of Presentation: 駒場
  • Year and Date: 2010-09-23
• [Presentation] メダカの集団学習に関わる個体間相互作用の解析とそれを担う脳領域の探索 (2010)
  • Author(s): 落合崇, 末廣勇司, 久保健雄, 竹内秀明
  • Organizer: 第16回小型魚類研究会
  • Place of Presentation: 埼玉
  • Year and Date: 2010-09-18
• [Presentation] メダカを用いたオスの配偶者防衛行動の解析 (2010)
  • Author(s): 横井佐織、奥山輝大、竹内秀明、久保健雄
  • Organizer: 第16回小型魚類研究会
  • Place of Presentation: 埼玉
  • Year and Date: 2010-09-18
• [Presentation] メダカを用いたオスの配偶者防衛行動の解析 (2010)
  • Author(s): 横井佐織、奥山輝大、竹内秀明、久保健雄
  • Organizer: 第16回 小型魚類研究会
  • Place of Presentation: 埼玉
  • Year and Date: 2010-09-18
• [Presentation] メダカの集団学習に関わる個体間相互作用の解析とそれを担う脳領域の探索 (2010)
  • Author(s): 落合崇, 末廣勇司, 久保健雄, 竹内秀明
  • Organizer: 第16回 小型魚類研究会
  • Place of Presentation: 埼玉
  • Year and Date: 2010-09-18
• [Presentation] Analysis of Social behaviors in Adult Medaka Fish (2010)
  • Author(s): Takeuchi, H.
  • Organizer: The BRH Seminar "Evolution & Diversity of Fishes(招待講演)
  • Place of Presentation: 大阪
  • Year and Date: 2010-06-24
• [Presentation] Analysis of Social behaviors in Adult Medaka Fish (2010)
  • Author(s): Hideaki Takeuchi
  • Organizer: The BRH Seminar "Evolution & Diversity of Fishes"
  • Place of Presentation: 大阪
  • Year and Date: 2010-06-24
• [Presentation] メダカの社会性行動を生み出す脳機能の解析 (2010)
  • Author(s): 竹内秀明
  • Organizer: 日本分子生物学会春季シンポジウム「身体・脳システムの心理表出行動と分子動態基盤(招待講演)
  • Place of Presentation: 松島
  • Year and Date: 2010-06-08
• [Presentation] 視覚依存の配偶者選別において行動異常を示すメダカ変異体の同定 (2010)
  • Author(s): 奥山輝大、末廣勇司、今田はるか、島田敦子、田中実、成瀬清、武田洋幸、久保健雄、竹内秀明
  • Organizer: 日本分子生物学会春季シンポジウム「身体・脳システムの心理表出行動と分子動態基盤」(招待講演)
  • Place of Presentation: 松島
  • Year and Date: 2010-06-08
• [Presentation] メダカの社会性行動を生み出す脳機能の解析 (2010)
  • Author(s): 竹内秀明
  • Organizer: 日本分子生物学会春季シンポジウム「身体・脳システムの心理表出行動と分子動態基盤」
  • Place of Presentation: 松島
  • Year and Date: 2010-06-08
• [Presentation] 視覚依存の配偶者選別において行動異常を示すメダカ変異体の同定 (2010)
  • Author(s): 奥山輝大、末廣勇司、今田はるか、島田敦子、田中実、成瀬清、武田洋幸、久保健雄、竹内秀明
  • Organizer: 日本分子生物学会春季シンポジウム「身体・脳システムの心理表出行動と分子動態基盤」
  • Place of Presentation: 松島
  • Year and Date: 2010-06-08
• [Presentation] Molecular/neural basis involved in social interaction among medaka fish (2010)
  • Author(s): Takeuchi, H.
  • Organizer: 第87回日本生理学会大会「比較的単純なモデル動物を用いた運動・行動研究」(招待講演)
  • Place of Presentation: 松島
  • Year and Date: 2010-05-21
• [Presentation] Molecular/neural basis involved in social interaction among medaka fish (2010)
  • Author(s): Hideaki Takeuchi
  • Organizer: 第87回日本生理学会大会「比較的単純なモデル動物を用いた運動・行動研究」
  • Place of Presentation: 盛岡
  • Year and Date: 2010-05-21
• [Presentation] メダカ近交系間における、視覚刺激に対する逃避様反応の定量的比較 (2009)
  • Author(s): 坪子理美、末廣勇司、奥山輝大、島田敦子、武田洋幸、成瀬清、久保健雄、竹内秀明
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-10
• [Presentation] 小型魚類メダカを用いた配偶者選別の分子・神経基盤解析 (2009)
  • Author(s): 奥山輝大、末廣勇司、今田はるか、島田敦子、武田洋幸、久保健雄、竹内秀明
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-10
• [Presentation] メダカ近交系間における、視覚刺激に対する逃避様反応の定量的比較 (2009)
  • Author(s): 坪子理美、末廣勇司、奥山輝大、島田敦子、武田洋幸、成瀬清、久保健雄、竹内秀明
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-12-10
• [Presentation] Neural Mechanism for Female Mating Acceptance of Medaka Mediated by Visual Information (2009)
  • Author(s): Teruhiro Okuyama, Yuji Suehiro, Haruka Imada, Atsuko Shimada, Minoru Tanaka, Kiyoshi Naruse, Hiroyuki Takeda, Takeo Kubo, Hideaki Takeuchi
  • Organizer: 第32回日本分子生物学会年会第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-12-10
• [Presentation] Optomotor response of medaka fish to rotating stripes at sinusoidal speed (2009)
  • Author(s): Yuji Suehiro, Teruhiro Okuyama, Haruka Imada, Kiyoshi Naruse, Daisuke Kurabayashi, Atsuko Shimada, Hiroyuki Takeda, Takeo Kubo, Hideaki Takeuchi.
  • Organizer: The 3rd International Symposium on Mobiligence
  • Place of Presentation: 淡路夢舞台国際会議場
  • Year and Date: 2009-11-20
• [Presentation] Mapping of brain regions involved in female mating acceptance mediated by visual information in medaka fish (2009)
  • Author(s): Okuyama, T., Suehiro, Y., Imada, H., Shimada, A., Naruse, K., Takeda, H., Kubo, T., Takeuchi H.
  • Organizer: The 39th annual meeting of the Society for Neuroscience
  • Place of Presentation: Chicago
  • Year and Date: 2009-10-19
• [Presentation] Analysis of neural mechanism for the optomotor response of the medaka fish (2009)
  • Author(s): Suehiro, Y., Okuyama, T., Imada, H., Shimada, A., Naruse, K., Kurabayashi, D., Takeda, T., Kubo, T., Takeuchi, H.
  • Organizer: The 39th annual meeting of the Society for Neuroscience
  • Place of Presentation: Chicago
  • Year and Date: 2009-10-19
• [Presentation] Analysis of neural mechanism for the optomotor response of the medaka fish (2009)
  • Author(s): Yuji Suehiro, Teruhiro Okuyama, Haruka Imada, Kiyoshi Naruse, Daisuke Kurabayashi, Atsuko Shimada, Hiroyuki Takeda, Takeo Kubo, Hideaki Takeuchi.
  • Organizer: The 39th annual meeting of the Society for Neuroscience
  • Place of Presentation: シカゴ、米国
  • Year and Date: 2009-10-18
• [Presentation] Mapping of brain regions involved in female mating acceptance mediated by visual information in medaka fish (2009)
  • Author(s): Teruhiro Okuyama, Yuji Suehiro, Haruka Imada, Atsuko Shimada, Minoru Tanaka, Kiyoshi Naruse, Hiroyuki Takeda, Takeo Kubo, Hideaki Takeuchi
  • Organizer: Society for Neuroscience neeting 2009
  • Place of Presentation: シカゴ、米国
  • Year and Date: 2009-10-18
• [Presentation] メダカOryzias latipes近交系間における、視覚刺激に対する逃避様行動の定量的比較 (2009)
  • Author(s): 坪子理美、末廣勇司、奥山輝大、島田敦子、武田洋幸、成瀬清、久保健雄、竹内秀明
  • Organizer: 日本動物学会第80回大会
  • Place of Presentation: 静岡
  • Year and Date: 2009-09-17
• [Presentation] メダカOryzias latipes近交系間における、視覚刺激に対する逃避様行動の定量的比較 (2009)
  • Author(s): 坪子理美、末廣勇司、奥山輝大、島田敦子、武田洋幸、成瀬清、久保健雄、竹内秀明
  • Organizer: 日本動物学会 第80回大会
  • Place of Presentation: 静岡コンベンションアーツセンター
  • Year and Date: 2009-09-17
• [Presentation] メダカ近交系間における、明暗刺激に対する逃避様反応の定量的比較 (2009)
  • Author(s): 坪子理美、末廣勇司、奥山輝大、島田敦子、武田洋幸、成瀬清、久保健雄、竹内秀明
  • Organizer: 第15回小型魚類研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-12
• [Presentation] メダカ近交系間における、明暗刺激に対する逃避様反応の定量的比較 (2009)
  • Author(s): 坪子理美、末廣勇司、奥山輝大、島田敦子、武田洋幸、成瀬清、久保健雄、竹内秀明
  • Organizer: 第15回小型魚類研究会
  • Place of Presentation: 名古屋大学野依記念学術交流館
  • Year and Date: 2009-09-12
• [Presentation] Analysis of The Neural and Molecular bases that Underlie Female Mating Acceptance of Medaka Depending on Visual Information (2009)
  • Author(s): Okuyama, T., Suehiro, Y., Imada, H., Shimada, A., Naruse, K., Takeda, H., Kubo, T., Takeuchi, H.
  • Organizer: The 18th CDB Meeting "Common Themes and New Concepts in Sensory Formation"
  • Place of Presentation: 神戸
  • Year and Date: 2009-04-14
• [Presentation] Analysis of neural mechanism for the optomotor response of the medaka fish (2009)
  • Author(s): Suehiro, Y., Okuyama, T., Imada, H., Shimada, A., Naruse, K., Takeda, H., Kubo, T., Takeuchi, H.
  • Organizer: The 18th CDB Meeting "Common Themes and New Concepts in Sensory Formation"
  • Place of Presentation: 神戸
  • Year and Date: 2009-04-14
• [Presentation] Analysis of Social Interactions Using Adult Medaka Fish (2009)
  • Author(s): Takeuchi, H.
  • Organizer: The 18th CDB Meeting "Common Themes and New Concepts in Sensory Formation" (招待講演)
  • Place of Presentation: 神戸
  • Year and Date: 2009-04-14
• [Presentation] Analysis of Social Interactions Using Adult Medaka Fish (2009)
  • Author(s): Hideaki Takeuchi
  • Organizer: Common Themes and New Concepts in Sensory Formation, The 18th CDB Meeting
  • Place of Presentation: 神戸 理化学研究所発生・再生科学総合研究センター
  • Year and Date: 2009-04-14
• [Presentation] Analysis of neural mechanism for the optomotor response of the medaka fish (2009)
  • Author(s): Yuji Suehiro, Teruhiro Okuyama, Haruka Imada, Kiyoshi Naruse, Daisuke Kurabayashi, Atsuko Shimada, Hiroyuki Takeda, Takeo Kubo, Hideaki Takeuchi.
  • Organizer: The 18^<th> CDB Meeting
  • Place of Presentation: 神戸 理化学研究所発生・再生科学総合研究センター
  • Year and Date: 2009-04-14
• [Presentation] Analysis of The Neural and Molecular bases that Underlie Female Mating Acceptance of Medaka Depending on Visual Information (2009)
  • Author(s): Teruhiro Okuyama, Yuji Suehiro, Haruka Imada, Atsuko Shimada, Minoru Tanaka, Kiyoshi Naruse, Hiroyuki Takeda, Takeo Kubo, Hideaki Takeachi
  • Organizer: Common Themes and New Concepts in Sensory Formation, The 18th CDB Meeting
  • Place of Presentation: 神戸 理化学研究所発生・再生科学総合研究センター
  • Year and Date: 2009-04-14
• [Remarks] ホームページ等
  • URL: http://researchmap.jp/Takeuchi/
• [Remarks]
  • URL: http://researchmap.jp/Takeuchi/
• [Remarks]
  • URL: http://researchmap.jp/Takeuchi/