Research Project
Grant-in-Aid for Young Scientists (B)
Accumulated evidence clearly indicates that ER stress is involved in the development of neurodegenerative disorders including Alzheimer's disease. We have investigated the functions of ER stress sensor OASIS, which is specifically expressed in astrocyte. Recently, we established OASIS-/- mouse which shows the increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainic acid. In this study, we found that OASIS expressed in astrocyte plays important roles on the expression and secretion of brain-derived neurotrophic factor (BDNF) to protect the neurons from the toxicity of kainic acid.
All 2011 2010 2009 Other
All Journal Article (8 results) (of which Peer Reviewed: 7 results) Presentation (10 results) Book (1 results) Remarks (3 results)
Journal of Agricultural and Food Chemistry
Volume: (印刷中)
J.Bone Miner.Metab. 28(2)
Pages: 131-138
10027207004
分子リウマチ治療
Volume: 3 Pages: 14-17
Journal of Bone and Mineral Metabolism 28(2)
Nat.Cell Biol. 11(10)
Pages: 1205-1211
J.Neurochem 110(3)
Pages: 956-965
Nature Cell Biology 11(10)
Journal of Neurochemistry 110(3)
http://www.med.u-fukui.ac.jp/biseibutu/
http://www.med.miyazaki-u.ac.jp/anatomyl/