Fundamental Study for Development of An Engineering Model of Remodeling Mechanism of Blood Vessel Walls in Response to Mechanical Environment
| Project/Area Number |
21700457
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Biomedical engineering/Biological material science
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
SAKAMOTO Naoya Tohoku University, 大学院・工学研究科, 助教 (20361115)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 生体システム・フィジオーム / 細胞・組織 / 力学刺激 / リモデリング / 血管内皮細胞 / 細胞外基質分解酵素 / 生物・生体工学 / 生物物理 |
|---|
| Research Abstract |
To understand quantitative relationship between hemodynamic environment and remodeling of vessel walls, I investigated functional changes in vascular endothelial cells (ECs) exposed to fluid shear stress conditions. The results indicate that EC activity in wall degradation is suppressed under a physiological shear stress condition and higher shear stress may enhance the activity in degradation of vessel walls. Furthermore, I found that spatial gradient of shear stress also has an impact on ECs functions, which may be crucial to formation of vascular diseases.
|
Report
(3 results)
Research Products
(43 results)
