Basic study of new minimally invasive cancer treatment method of by particle sensitization method.

• Project/Area Number: 21700514
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Medical systems
• Research Institution: Gunma University
• Principal Investigator: SHIMADA Hirofumi Gunma University, 重粒子線医学推進機構, 助教 (10414575)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 医療・福祉 / 癌 / 重粒子線治療 / 光線力学的療法 / 放射線化学 / 蛍光プローブ / 光線力学療法

Research Abstract

It was able to be confirmed that fluorescence was measured by optical excitation of the irradiation sample after it irradiated it from the upper side while stirring various samples, and the generation of active oxygen species was promoted by the presence of the medicine for PDT. The cytotoxicity reaction was able to be found the survival rate of the cell decreasing compared with the control group that had not added the machine screw dyne, and improving by irradiating and using together with the photosensitization medicine when X rays were irradiated by using lung cancer epithelial cell (A-549) and the machine screw dyne (5 Gy).