Evaluation of herb by activation of PPARs and suppression of COX-2 expression
| Project/Area Number |
21700753
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Nara Women's University |
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Principal Investigator |
KATSUKAWA Michiko Nara Women's University, 生活環境学部, 助教 (20508519)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | COX-2 / PPAR / ハーブ / 機能性評価 |
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| Research Abstract |
Lemongrass is a widely used herb as a food flavoring, as a perfume, and for its analgesic and anti-inflammatory purposes; however, the molecular mechanisms of these effects have not been elucidated. In this study, we evaluated the essential oil of lemongrass using our established assays for COX-2, a key enzyme for prostaglandin synthesis, and PPAR, a molecular target for "lifestyle-related" diseases. We identified citral from the essential oil of lemongrass as a suppressor of COX-2 and also an activator of PPAR.
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Report
(3 results)
Research Products
(16 results)
