Effect of unbalanced diet on expression of gut disease-associated gene and intestinal microflora
| Project/Area Number |
21700757
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | The University of Tokushima |
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Principal Investigator |
ARIMOCHI Hideki The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (30311822)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 腸内細菌 / 大腸癌細胞 / サイトカイン / 腸内菌 / 腸疾患 / 大腸癌 / Bacteroides属 / マトリックスメタロプロテアーゼ |
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| Research Abstract |
Bacteroides fragilis, B.vulgatus, and B.thetaiotaomicron were attached on colon tumor cells, then matrix metalloprotease and cytokines produced by the cells were determined. These bacteria could induce these proteins but the level and the pattern of the proteins was quietly different. The differences of the expression pattern were also observed after challenging with distinct strains in one species of bacteria. These results suggest that proteins associated with development of intestinal disease are affected by bacteria attached on intestinal epithelial cells, and their expression pattern is very complicated.
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Report
(3 results)
Research Products
(1 results)
