Functional food to help reduce the risk of diabetic complications
| Project/Area Number |
21700765
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
ITO Tomoko (OYA Tomoko) 京都府立医科大学, 医学研究科, 准教授 (80329648)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 健康と食生活 / 糖尿病合併症 / 酸化ストレス / 消化管 / プロテオミクス解析 / 翻訳後修飾 / がん / 糖化反応 / 食品 / ストレス / 癌 / 糖尿病 / タンパク質 |
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| Research Abstract |
Methylglyoxal (MG), an endogenous metabolite that increases in diabetes and is a common intermediate in the Maillard reaction (glycation), reacts with proteins and forms advanced glycation end products. (1) By using a monoclonal antibody to MG-modified proteins, we found that heat-shock protein 27 (Hsp27) was modified by MGin ascending colon and rectum of patients with cancer. However, MG-modified Hsp25/Hsp27 was not detected in non cancerous cell lines or in normal subject. (2) Many tea extracts and antioxidants inhibited both generation of reactive oxygen species and impaired phagocytosis in neutrophils under high glucose condition. It is expected that a number of antioxidant can prevent the development of diabetes and inflammatory disease.
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Report
(4 results)
Research Products
(99 results)
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[Journal Article] Hemopexin is upregulated in rat intestinal mucosa injured by indomethacin2012
Author(s)
Takagi T, Naito Y, Okada H, Takaoka M, Oya-Ito T, Yamada S, Hirai Y, Mizushima K, Yoshida N, Kamada K,Katada K, Uchiyama K, Ishikawa T, Handa O, Yagi N, Konishi H, Kokura S, Ichikawa H, Yoshikawa T
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Journal Title
J Gastroenterol Hepatol
Volume: J Gastroenterol Hepatol
Issue: s3
Pages: 70-75
DOI
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Peer Reviewed
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[Journal Article] Identification of dihalogenated proteins in rat intestinal mucosa injured by indomethacin2011
Author(s)
Takagi T, Naito Y, Okada H, Okayama T, Mizushima K, Yamada S, Fukumoto K, Inoue K, Takaoka M, Oya-Ito T, Uchiyama K, Ishikawa T, Handa O, Kokura S, Yagi N, Ichikawa H, Kato Y, Osawa T, Yoshikawa T
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Journal Title
Journal of Clinical Biochemistry and Nutrition
Volume: 48
Issue: 2
Pages: 178-182
DOI
NAID
ISSN
0912-0009, 1880-5086
Related Report
Peer Reviewed
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[Journal Article] Identification of dihalogenated proteins in rat intestinal mucosa injured by indomethacin2011
Author(s)
Takagi T, Naito Y, Okada H, Okayama T, Mizushima K, Yamada S, Fukumoto K, Inoue K, Takaoka M, Oya-Ito T, Uchiyama K, Ishikawa T, Handa O, Kokura S, Yagi N, Ichikawa H, Kato Y, Osawa T, Yoshikawa T
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Journal Title
J Clin Biochem Nutr
Volume: 48(2)
Pages: 178-182
Related Report
Peer Reviewed
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[Journal Article] Impaired gastric ulcer healing in diabetic mice: role of methylglyoxal2009
Author(s)
Naito Y, Takagi T, Oya-Ito T, Okada H, Suzuki T, Hirata I, Hirai M, Uchiyama K, Handa O, Uchida K, Yoshikawa T
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Journal Title
J Physiol Pharmacol
Volume: vol.60
Pages: 123-130
Related Report
Peer Reviewed
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[Journal Article] Impaired gastric ulcer healing in diabetic mice : role of methylglyoxal.2009
Author(s)
Naito Y, Takagi T, Oya-Ito T, Okada H, Suzuki T, Hirata I, Hirai M, Uchiyama K, Handa O, Uchida K, Yoshikawa T.
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Journal Title
J Physiol Pharmacol.
Volume: 60
Pages: 123-130
Related Report
Peer Reviewed
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[Presentation] Identification of Dihalogenated Proteins involved in Rat Intestinal Mucosa Injured by Indomethacin2010
Author(s)
Yoriki H, Naito Y, Takagi T, Handa O, Okada H, Oya-Ito T, Uchiyama K, Ichikawa H, Kato Y, Osawa T, Yoshikawa T
Organizer
SFRBM's 17th Annual Meeting
Place of Presentation
Caribe Royale Hotel & Conference Center(Orland, USA)
Year and Date
2010-11-19
Related Report
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[Presentation] Identification of acrolein modified proteins Involved in the pathogenesis of delayed gastric ulcer healing in diabetic mice2010
Author(s)
Horie R, Naito Y, Takagi T, Handa O, Oya-Ito T, Okada H, Uchiyama K, Ichikawa H, Uchida K, Yoshikawa T
Organizer
SFRBM's 17th Annual Meeting
Place of Presentation
Caribe Royale Hotel & Conference Center(Orland, USA)
Year and Date
2010-11-19
Related Report
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[Presentation] Identification of acrolein modified proteins Involved in the pathogenesis of delayed gastric ulcer healing in diabetic mice2010
Author(s)
Horie R, Naito Y, Takagi T, Handa O, Oya-Ito T, Okada H, Uchiyama K, Ichikawa H, Uchida K, Yoshikawa T
Organizer
SFRBM's 17th Annual Meeting
Place of Presentation
Caribe Royale Hotel & Conference Center (Orland, USA)
Year and Date
2010-11-19
Related Report
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[Presentation] Identification of Dihalogenated Proteins involved in Rat Intestinal Mucosa Injured by Indomethacin2010
Author(s)
Yoriki H, Naito Y, Takagi T, Handa O, Okada H, Oya-Ito T, Uchiyama K, Ichikawa H, Kato Y, Osawa T, Yoshikawa T
Organizer
SFRBM's 17th Annual Meeting
Place of Presentation
Caribe Royale Hotel & Conference Center (Orland, USA)
Year and Date
2010-11-19
Related Report
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[Presentation] 加齢性糖代謝不全マウスにおける骨格筋アデニル酸キナーゼのニトロ化修飾2010
Author(s)
青井渉, 内藤裕二, 岡田ひとみ, 大矢友子, 高波嘉一, 川合ゆかり, 谷村祐子, 市川寛, 加藤陽二, 大澤俊彦, 吉川敏
Organizer
第63回日本酸化ストレス学会学術集会
Place of Presentation
神奈川県県民ホール(神奈川)
Year and Date
2010-06-24
Related Report
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[Presentation] 炎症性腸疾患における抗酸化酵素Peroxiredoxin-VIの役割2010
Author(s)
高木智久, 内藤祐二, 尾松達司, 岡田ひとみ, 高岡恵, 大矢友子, 水島かつら, 林奈津子, 平井素子, 石川剛, 半田修, 八木信明, 古倉聡, 市川寛, 吉川敏一
Organizer
第63回日本酸化ストレス学会学術集会
Place of Presentation
神奈川県県民ホール(神奈川)
Year and Date
2010-06-24
Related Report
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[Presentation] Identification of Acrolein Modified Proteins in the Gastric Ulcer Mucosa of Diabetic Mice2010
Author(s)
Takagi T, Naito Y, Oya-Ito T, Suzuki T, Mizushima K, Hayashi N, Hirata I, Okada H, Horie R, Yoshida N, Uchiyama K, Uchiyama K, Ishikawa T, Handa O, Konishi H, Wakabayashi N, Yagi N, Kokura S, Ichikawa H, Yoshikawa T
Organizer
2010 Digestive Disease Week
Place of Presentation
New Orleans, USA.
Year and Date
2010-05-05
Related Report
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[Presentation] Identification of Acrolein Modified Proteins in the Gastric Ulcer Mucosaod Diabetic Mice2010
Author(s)
Takagi T, Naito Y, Oya-Ito T, Suzuki T, Mizushima K, Hayashi N, Hirata I, Okada H, Horie R, Yoshida N, Uchiyama K, Uchiyama K, Ishikawa T, Handa O, Konishi H, Wakabayashi N, Yagi N, Kokura S, Ichikawa H, Yoshikawa T
Organizer
2010 Digestive Disease Week
Place of Presentation
New Orleans, USA
Year and Date
2010-05-05
Related Report
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[Presentation] The expression of peroxiredoxin-vi (prxvi) in murine dextran sodium sulfate (DSS)-induced colitis2009
Author(s)
Takagi T, Naito Y, Omatsu T, Okada H, Oya-Ito T, Mizushima K, Hayashi N, Hirai Y, Harusato A, Fukumoto K, Yamada S, Inoue K, Horie R, Hirata I, Ishikawa T, Handa O, Kokura S, Ichikawa H, Yoshikawa T
Organizer
5th Joint Meeting of The Societies for Free Radical Research Australasia and Japan
Place of Presentation
VeterinaryScience Conference Centre, University of Sydney (Sydney, Australia)
Year and Date
2009-12-01
Related Report
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[Presentation] The expression of peroxiredoxin-vi (prxvi) in murine dextran sodium sulfate(DSS)-induced colitis.2009
Author(s)
Takagi T, Naito Y, Omatsu T, Okada H, Oya-Ito T, Mizushima K, Hayashi N, Hirai Y, Harusato A, Fukumoto K, Yamada S, Inoue K, Horie R, Hirata I, Ishikawa T, Handa O, Kokura S, Ichikawa H, Yoshikawa T.
Organizer
5th Joint Meeting of The Societies for Free Radical Research Australasia and Japan.
Place of Presentation
Sydney, Australia.
Year and Date
2009-12-01
Related Report
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[Presentation] Proteomic discovery of the down-regulation of peroxiredoxin-6 in murine dextran sodium sulfate-induced colitis2009
Author(s)
Omatsu T, Naito Y, Takagi T, Mizushima K, Okada H, Inoue K, Yamada S, Fukumoto K, Harusato A, Hirata I, Oya-Ito T, Uchiyama K, Handa O, Yagi N, Kokura S, Ichikawa H, Yoshikawa T
Organizer
The United European Gastroenterology Week 2009
Place of Presentation
ExCeL London (London, UK)
Year and Date
2009-11-24
Related Report
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[Presentation] Proteomic discovery of the down-regulation of peroxiredoxin-6 in murine dextran sodium sulfate-induced colitis.2009
Author(s)
Omatsu T, Naito Y, Takagi T, Mizushima K, Okada H, Inoue K, Yamada S, Fukumoto K, Harusato A, Hirata I, Oya-Ito T, Uchiyama K, Handa O, Yagi N, Kokura S, Ichikawa H, Yoshikawa T.
Organizer
The United European Gastroenterology Week 2009.
Place of Presentation
London, UK.
Year and Date
2009-11-24
Related Report
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[Presentation] The exhaustive proteomics revealed the down-regulation of peroxiredoxin-6 in murine dextran sodium sulfate-induced colitis2009
Author(s)
Omatsu T, Naito Y, Takagi T, Mizushima K, Okada H, Inoue K, Yamada S, Fukumoto K, Harusato A, Hirata I, Oya-Ito T, Handa O, Yagi N, Kokura S, Ichikawa H, Yoshikawa T
Organizer
The 14th International Congress of Mucosal Immunology
Place of Presentation
Marriott Boston Copley Place (Boston, USA)
Year and Date
2009-07-07
Related Report
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[Presentation] The exhaustive proteomics revealed the down-regulation of peroxiredoxin-6 in murine dextran sodium sulfate-induced colitis.2009
Author(s)
Omatsu T, Naito Y, Takagi T, Mizushima K, Okada H, Inoue K, Yamada S, Fukumoto K, Harusato A, Hirata I, Oya-Ito T, Handa O, Yagi N, Kokura S, Ichikawa H, Yoshikawa T.
Organizer
The 14th International Congress of Mucosal Immunology.
Place of Presentation
Boston, USA.
Year and Date
2009-07-07
Related Report
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[Presentation] Decreased expression of peroxiredoxin-6 in murine dextran sodium sulfate-induced colitis identified by 2-dimensional fluorescence difference in gel electrophoresis2009
Author(s)
Omatsu T, Naito Y, Takagi T, Mizushima K, Okada H, Fukumoto K, Harusato A, Hirata I, Hamano Y, Oya-Ito T, Handa O, Yagi N, Kokura S, Ichikawa H, Fujiwake H, Yoshikawa T
Organizer
The 110th Annual Meeting of the AGA Institute.Digestive Disease Week
Place of Presentation
Chicago, USA
Year and Date
2009-05-31
Related Report
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[Presentation] Decreased expression of peroxiredoxin-6 in murine dextran sodium sulfate-induced colitis identified by 2-dimensional fluorescence difference ingel electrophoresis.2009
Author(s)
Omatsu T, Naito Y, Takagi T, Mizushima K, Okada H, Fukumoto K, Harusato A, Hirata I, Hamano Y, Oya-Ito T, Handa O, Yagi N, Kokura S, Ichikawa H, Fujiwake H, Yoshikawa T.
Organizer
The 110th Annual Meeting of the AGA Institute.Digestive Disease Week.
Place of Presentation
Chicago, USA.
Year and Date
2009-05-31
Related Report
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[Book] 消化器と免疫NO.46マウス腸炎モデルに対するプロテオミクス的手法を用いたアプローチ-ペルオキシレドキシン6発現低下の発見-(恩地森一監修,日比紀文,淀井淳司,渡辺守他編集)2010
Author(s)
尾松達司, 内藤裕二, 高木智久, 岡田ひとみ, 大矢友子, 水島かつら, 平井泰子, 福本晃平, 春里暁人, 平田育大, 内山和彦, 半田修, 八木信明, 古倉聡, 市川寛, 吉川敏一
Publisher
(株)マイライフ(東京)
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