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脂肪組織内のBCMO1及びCRBP発現の調節に関する研究

Research Project

Project/Area Number 21700767
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Eating habits, studies on eating habits
Research InstitutionUniversity of Nagasaki

Principal Investigator

YAMAGUCHI Noriaki  University of Nagasaki, 看護栄養学部, 助教 (80516295)

Co-Investigator(Renkei-kenkyūsha) SURUGA Kazuhito  長崎県立大学, 看護栄養学部, 准教授 (70315852)
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords食と栄養 / OLETFラット / 3T3L-1細胞 / βカロテン / ビタミンA / PPARβ/δ / 脂肪細胞 / 肥満 / レチノイン酸 / BCMO1 / RALDH1 / CRBP
Research Abstract

Some vitamin A metabolism-related genes were changed in adipose tissues of OLETF rats. Especially RALDH1 gene expression and contents of retinoic acid were decreased in the adipose tissues, suggesting that ability of products of retinoic acid might be lower under obesity. Additionally, β-carotene might suppressed differentiation and maturity in 3T3L-1 cells by activating PPARβ/δ.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (4 results)

All 2011 2010 2009

All Presentation (4 results)

  • [Presentation] OLETFラット脂肪組織および3T3L-1前駆脂肪細胞のビタミンA代謝関連遺伝子の発現変動に関する研究2011

    • Author(s)
      山口範晃、野口沙知子、駿河和仁
    • Organizer
      日本栄養食糧学会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-15
    • Related Report
      2010 Final Research Report
  • [Presentation] 肥満発症ラットOLETFの脂肪組織および3T3L-1脂肪細胞におけるビタミンA代謝関連遺伝子の変動2010

    • Author(s)
      山口範晃、駿河和仁
    • Organizer
      BMB2010
    • Place of Presentation
      神戸市
    • Year and Date
      2010-12-07
    • Related Report
      2010 Final Research Report
  • [Presentation] 肥満発症ラットOLETFの脂肪組織および3T3L-1脂肪細胞におけるビタミンA代謝関連遺伝子の変動2010

    • Author(s)
      山口範晃
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト小腸のβカロテン開裂酵素の遺伝子発現に及ぼすHNF-1αとHNF-4αの影響2009

    • Author(s)
      山口範晃、駿河和仁
    • Organizer
      第63回日本栄養・食糧学会
    • Place of Presentation
      長崎市
    • Year and Date
      2009-05-21
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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