脂肪組織内のBCMO1及びCRBP発現の調節に関する研究
| Project/Area Number |
21700767
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | University of Nagasaki |
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Principal Investigator |
YAMAGUCHI Noriaki University of Nagasaki, 看護栄養学部, 助教 (80516295)
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| Co-Investigator(Renkei-kenkyūsha) |
SURUGA Kazuhito 長崎県立大学, 看護栄養学部, 准教授 (70315852)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 食と栄養 / OLETFラット / 3T3L-1細胞 / βカロテン / ビタミンA / PPARβ/δ / 脂肪細胞 / 肥満 / レチノイン酸 / BCMO1 / RALDH1 / CRBP |
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| Research Abstract |
Some vitamin A metabolism-related genes were changed in adipose tissues of OLETF rats. Especially RALDH1 gene expression and contents of retinoic acid were decreased in the adipose tissues, suggesting that ability of products of retinoic acid might be lower under obesity. Additionally, β-carotene might suppressed differentiation and maturity in 3T3L-1 cells by activating PPARβ/δ.
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Report
(3 results)
Research Products
(4 results)
