| Project/Area Number |
21710034
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Environmental impact assessment/Environmental policy
|
|---|
| Research Institution | Ehime University |
|---|
Principal Investigator |
NISHIMOTO Sogo Ehime University, 沿岸環境科学研究センター・グローバル, COE研究員 (70392066)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | 健康影響評価 / 免疫撹乱化学物質 / 免疫 / 農薬 / 環境化学物質 / 精子形成 / 環境リスク / テストステロン / 健康 / エンドサルファン / アレルギー / サイトカイン |
|---|
| Research Abstract |
In this research, we investigated the influence of endosulfan used in various countries on mammalian immune system, especially allergy response. Endosulfan increased the amount of antigen-specific IgE in serum from allergy-induced mice. Moreover, endosulfan enhanced the IL-4 production in serum and splenocytes culture medium. Endosulfan not only induced the initiation of allergy response, but also stimulated the release of chemical mediator as inflammatory substances. We suggested that the effect of endosulfan was concerned with both initiation and inflammation.
|
