The effect of pesticides on mammalian immune system

• Project/Area Number: 21710034
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Environmental impact assessment/Environmental policy
• Research Institution: Ehime University
• Principal Investigator: NISHIMOTO Sogo Ehime University, 沿岸環境科学研究センター・グローバル, COE研究員 (70392066)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 健康影響評価 / 免疫撹乱化学物質 / 免疫 / 農薬 / 環境化学物質 / 精子形成 / 環境リスク / テストステロン / 健康 / エンドサルファン / アレルギー / サイトカイン

Research Abstract

In this research, we investigated the influence of endosulfan used in various countries on mammalian immune system, especially allergy response. Endosulfan increased the amount of antigen-specific IgE in serum from allergy-induced mice. Moreover, endosulfan enhanced the IL-4 production in serum and splenocytes culture medium. Endosulfan not only induced the initiation of allergy response, but also stimulated the release of chemical mediator as inflammatory substances. We suggested that the effect of endosulfan was concerned with both initiation and inflammation.

Research Products

• [Journal Article] Inhibition of myotube formation by paraquat in the myoblast cell line C2C12. (2011)
  • Author(s): Akiyama, K., et al.
  • Journal Title: The Journal of Toxicological Sciences Volume: (In press)
  • Peer Reviewed
• [Journal Article] Bfr1p is responsible for tributyltin resistance in Schizosaccharomyces pombe. (2011)
  • Author(s): Akiyama, K., et al.
  • Journal Title: The Journal of Toxicological Sciences Volume: 36 Pages: 117-120
  • Peer Reviewed
• [Journal Article] Oral administration of paraquat perturbs immunoglobulin productivity in mouse. (2010)
  • Author(s): Okabe, M., et al.
  • Journal Title: The Journal of Toxicological Sciences Volume: 35 Pages: 257-263
  • Peer Reviewed
• [Journal Article] Oral administration of paraquat perturbs immunoglobulin productivity in mouse. (2010)
  • Author(s): Okabe, M., et al.
  • Journal Title: The Journal of Toxicological Sciences 35 Pages: 257-263
  • Peer Reviewed
• [Journal Article] The effects of pesticides on immune cells. (2009)
  • Author(s): Nishimoto, S., Kanda, K., Okabe, M., Akiyama, K., Kakinuma, Y., Sugahara, T.
  • Journal Title: Animal Cell Technology : Basic, Applied Aspects 1 6 Pages: 377-381
• [Journal Article] Heavy oil fractions induce the negative influences on mouse immune system. (2009)
  • Author(s): Nishimoto, S., Kanda, K., Yamawaki, M., Okabe, M., Akiyama, K., Kakinuma, Y., Sugahara, T.
  • Journal Title: The Journal of Toxicological Sciences 3 4 Pages: 459-468
  • NAID: 110007358582
  • Peer Reviewed
• [Journal Article] abnormalities in the reproductive organs of mice caused by chemical substances in heavy oil. (2009)
  • Author(s): Nishimoto, S., Yamawaki, M., Akiyama, K., Kakinuma, Y., Kitamura, S-I., Sugahara, T.Severe
  • Journal Title: The Journal of Toxicological Sciences 3 4 Pages: 239-324
  • Peer Reviewed
• [Journal Article] Abnormal response induced by pesticides in mammalian immune system. (2009)
  • Author(s): Nishimoto, S., Kanda, K., Okabe, M., Akiyama, K., Kakinuma, Y., Sugahara, T.
  • Journal Title: Interdisciplinary Studies on Environmental Chemistry 2 Pages: 211-217
  • Peer Reviewed
• [Journal Article] Heavy oil fractions induce the negative influences on mouse immune system. (2009)
  • Author(s): Nishimoto, S., et al.
  • Journal Title: The Journal of Toxicological Sciences 34 Pages: 459-468
  • NAID: 110007358582
  • Peer Reviewed
• [Journal Article] Severe abnormalities in the reproductive organs of mice caused by chemical substances in heavy oil. (2009)
  • Author(s): Nishimoto, S., et al.
  • Journal Title: The Journal of Toxicological Sciences 34 Pages: 239-244
  • Peer Reviewed
• [Presentation] エンドスルファンが雄マウスの生殖系に及ぼす影響 (2011)
  • Author(s): 細羽康介、西本壮吾、中田雄一郎、柿沼喜己、菅原卓也
  • Organizer: 日本農芸化学会2011年度大会
  • Place of Presentation: 京都
  • Year and Date: 2011-03-27
• [Presentation] オルトフェニルフェノールの生体毒性について (2011)
  • Author(s): 中田雄一郎、西本壮吾、柿沼喜己、細羽康介、菅原卓也
  • Organizer: 日本農芸化学会2011年度大会
  • Place of Presentation: 京都
  • Year and Date: 2011-03-27
• [Presentation] エンドスルファンが雄マウスの生殖系に及ぼす影響 (2011)
  • Author(s): 細羽康介, 他
  • Organizer: 日本農芸化学会 2011年度大会
  • Place of Presentation: 京都女子大学(京都府)
  • Year and Date: 2011-03-27
• [Presentation] オルトフェニルフェノールの生体毒性について (2011)
  • Author(s): 中田雄郎, 他
  • Organizer: 日本農芸化学会 2011年度大会
  • Place of Presentation: 京都女子大学(京都府)
  • Year and Date: 2011-03-27
• [Presentation] The risk assessment of chemical substances in heavy oil on mammalian reproductive organs. (2010)
  • Author(s): Nishimoto, S., Akiyama, K., Kakinuma, Y., Sugahara, T.
  • Organizer: The 5th Global COE international Symposium.Modeling and Analysis of Marine Environmental Problems
  • Place of Presentation: Matsuyama, Japan.
  • Year and Date: 2010-09-22
• [Presentation] Endosulfan exaggerates allergy symptoms. (2010)
  • Author(s): Sugahara, T., Nishimoto, S., Atobe, S., Hosoba, K., Kakinuma, Y.
  • Organizer: The 5th Global COE international Symposium.Modeling and Analysis of Marine Environmental Problems.
  • Place of Presentation: Matsuyama, Japan
  • Year and Date: 2010-09-22
• [Presentation] The risk assessment of chemical substances in heavy oil on mammalian reproductive organs. (2010)
  • Author(s): Nishimoto S., et al.
  • Organizer: The 5th Global COE international Symposium.Modeling and Analysis of Marine Environmental Problems.
  • Place of Presentation: 愛媛大学(愛媛県)
  • Year and Date: 2010-09-22
• [Presentation] Endosulfan exaggerates allergy symptoms. (2010)
  • Author(s): Sugahara T., et al.
  • Organizer: The 5th Global COE international Symposium.Modeling and Analysis of Marine Environmental Problems.
  • Place of Presentation: 愛媛大学(愛媛県)
  • Year and Date: 2010-09-22
• [Presentation] Influence of endosulfan on allergic response in mouse. (2010)
  • Author(s): Nishimoto, S., Atobe, S., Okabe, M., Akiyama, K., Kakinuma, Y., Sugahara, T.
  • Organizer: The 14th International Biotechnology Symposium and Exhibition.P-M.64,
  • Place of Presentation: Rimini, Italy
  • Year and Date: 2010-09-14
• [Presentation] Influence of endosulfan on allergic response in mouse. (2010)
  • Author(s): Nishimoto S., et al.
  • Organizer: The 14th International Biotechnology Symposium and Exhibition.
  • Place of Presentation: Rimini, Italy
  • Year and Date: 2010-09-14
• [Presentation] Immunoglobulin productivity is perturbed by the oral administration of paraquot in mouse. (2010)
  • Author(s): Okabe M., et al.
  • Organizer: The 14th International Biotechnology Symposium and Exhibition.
  • Place of Presentation: Rimini, Italy
  • Year and Date: 2010-09-14
• [Presentation] Influence of chemical compounds in heavy oil on mouse reproductive system. (2010)
  • Author(s): Nishimoto, S., Okabe, M., Akiyama, K., Kakinuma, Y., Sugahara, T.
  • Organizer: The 23th Annual and International Meeting of the Japanese Association for Animal Cell Technology, p.215.
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2010-09-03
• [Presentation] Effect of endosulfan on allergic response. (2010)
  • Author(s): Sugahara, T., Nishimoto, S., Atobe, S., Hosoba, K., Kakinuma, Y.
  • Organizer: The 23th Annual and International Meeting of the Japanese Association for Animal Cell Technology, p.211.(2010)
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2010-09-03
• [Presentation] Influence of chemical compounds in heavy oil on mouse reproductive system. (2010)
  • Author(s): Nishimoto S., et al.
  • Organizer: The 23th Annual and International Meeting of the Japanese Association for Animal Cell Technology
  • Place of Presentation: 北海道大学(札幌)
  • Year and Date: 2010-09-03
• [Presentation] Effect of endosulfan on allergic response. (2010)
  • Author(s): Sugahara T., et al.
  • Organizer: The 23th Annual and International Meeting of the Japanese Association for Animal Cell Technology
  • Place of Presentation: 北海道大学(札幌)
  • Year and Date: 2010-09-03
• [Presentation] 重油水溶性画分がマウス生殖系に及ぼす影響 (2010)
  • Author(s): 西本壮吾、岡部正明、秋山浩一、柿沼喜己、菅原卓也
  • Organizer: 日本農芸化学会2010年度大会
  • Place of Presentation: 東京
  • Year and Date: 2010-03-28
• [Presentation] β-endosulfan のマウス免疫系に与える影響 (2010)
  • Author(s): 跡部聡子、西本壮吾、岡部正明、柿沼喜己、菅原卓也
  • Organizer: 日本農芸化学会2010年度大会
  • Place of Presentation: 東京
  • Year and Date: 2010-03-28
• [Presentation] β-endosulfanのマウス免疫系に与える影響 (2010)
  • Author(s): 跡部聡子, 他
  • Organizer: 日本農芸化学会
  • Place of Presentation: 東大駒場キャンパス(東京都)
  • Year and Date: 2010-03-28
• [Presentation] 重油水溶性画分がマウス生殖系に及ぼす影響 (2010)
  • Author(s): 西本壮吾, 他
  • Organizer: 日本農芸化学会
  • Place of Presentation: 東大駒場キャンパス(東京都)
  • Year and Date: 2010-03-28
• [Presentation] パラコートによる抗体産生かく乱作用 (2010)
  • Author(s): 岡部正明, 他
  • Organizer: 日本農芸化学会
  • Place of Presentation: 東大駒場キャンパス(東京都)
  • Year and Date: 2010-03-28
• [Presentation] パラコートによる筋芽細胞の筋管細胞への分化制御 (2009)
  • Author(s): 秋山浩一, 他
  • Organizer: 日本分子生物学会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-12-12
• [Presentation] マウスの免疫機能に及ぼすパラコートの経口投与の影響 (2009)
  • Author(s): 岡部正明, 他
  • Organizer: 日本農芸化学会関西・中四国・西日本支部、日本栄養・食糧学会九州・沖縄支部、日本食品科学工学会西日本支部2009年度合同沖縄大会
  • Place of Presentation: 琉球大学(沖縄県)
  • Year and Date: 2009-10-31
• [Book] Animal Cell Technology : Basic & Applied Aspects (2010)
  • Author(s): Nishimoto S., et al.
  • Publisher: Springer
• [Book] Animal Cell Technology : Basic & Applied Aspects (2010)
  • Author(s): Okabe M., et al.
  • Publisher: Springer
• [Book] Interdisciplinary Studies on Environmental Chemistry, vol.2, Environmental Research in Asia for Establishing a Scientist's Network (2009)
  • Author(s): Nishimoto, S., et al.
  • Publisher: TERRAPUB
• [Book] Interdisciplinary Studies on Environmental Chemistry, vol.2, Environmental Research in Asia for Establishing a Scientist's Network (2009)
  • Author(s): Okabe, S., et al.
  • Publisher: TERRAPUB