Mechanical control of the Brownian process for bio nano-motors
| Project/Area Number |
21710120
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | Osaka University |
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Principal Investigator |
IWAKI Mitsuhiro Osaka University, 医学系研究科, 助教 (30432503)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 1分子生理 / 生化学 / 生体ナノモーター / ミオシン / 1分子計測 / 1分子操作 / レーザートラップ / 確率共鳴 |
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| Research Abstract |
I constructed the dark-field microscopy combined with an optical trap for the single molecule measurements. Using this apparatus, I succeeded in both direct observation of Brownian search process in the stepping motion of bio nano-motor, myosin-V and mechanical control of the process. Dwell time analysis, noise analysis for the Brownian process and the load dependency enabled us to model bio nano-motor from a viewpoint of the roll of thermal noise in mechanical function. This is an important result toward control of nano-machine using noise such as stochastic resonance.
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Report
(3 results)
Research Products
(51 results)
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[Presentation] Micro-mechanicalmodelofmusclecontraction2009
Author(s)
L.Marcucci, T.Shimokawa, M.Iwaki, T.Yanagida
Organizer
International Workshop on Single molecule spectroscopy and ultra sensitive analysis in the life sciences
Place of Presentation
Berlin, Berlin-Adlershof, Germany
Related Report
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