Chemical biology on Phytophthora mating hormone α1

• Project/Area Number: 21710239
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Living organism molecular science
• Research Institution: Tokyo University of Agriculture
• Principal Investigator: YAJIMA Arata Tokyo University of Agriculture, 応用生物科学部, 准教授 (30328546)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: ケミカルバイオロジー / 疫病菌 / Phytophthora / 化学プローブ / 有機合成化学 / 全合成

Research Abstract

The novel sexual oospore inducing hormone α2 produced by A2 mating type of Phytophthora was synthesized. The absolute configuration of the natural product was determined. The chemical probes of hormone α1 derivatives were also prepared.

Research Products

• [Presentation] 綺麗なものを作ったからこそ起こったこと (2010)
  • Author(s): 矢島新
  • Organizer: 第45回天然物化学談話会
  • Place of Presentation: 三谷温泉ホテル明山荘(蒲郡)
  • Year and Date: 2010-07-07
• [Presentation] 病害虫に活性を有する天然有機化合物の合成 (2010)
  • Author(s): 矢島新
  • Organizer: 第14回農薬相模セミナー
  • Place of Presentation: 相模中央化学研究所(神奈川)
  • Year and Date: 2010-01-08
• [Presentation] Synthesis and SAR studies of Phytophthora mating hormone α1 (2009)
  • Author(s): 矢島新
  • Organizer: The 11th International Kyoto Conference on New Aspects of Organic Chemistry
  • Place of Presentation: リーガロイヤルホテル(京都)
  • Year and Date: 2009-11-10
• [Presentation] Synthetic studies on agriculturally important bioactive natural compounds (2009)
  • Author(s): 矢島新
  • Organizer: 5th Sino-Japanese Symposium on Organic Chemistry for Young Scientists(招待講演)
  • Place of Presentation: 中華人民共和国成都
  • Year and Date: 2009-10-11
• [Presentation] Shylaja, Harumi Kanazawa, Tomoo Nukada, Youji Sakagami, Goro Yabuta (2009)
  • Author(s): Arata Yajima, Makoto Ojika, Keisuke Shikai, Tadashi Imaoka, Tomoyo Asano, Jinhua Qi, Molli D.
  • Organizer: Synthesis and SAR studies of Phytophthora mating hormone a1(IKCOC-11)
  • Place of Presentation: 京都
• [Presentation] Synthetic studies on agriculturally important bioactive natural compounds (2009)
  • Author(s): Arata Yajima
  • Organizer: 5th Sino-Japanese Symposium on Organic Chemistry for Young Scientists
  • Place of Presentation: Chengdu
• [Presentation] 疫病菌Phytophthoraの繁殖誘導ホルモンa1の構造活性相関 (2009)
  • Author(s): 四海圭祐、今岡忠、浅野友世、威建華、Mollid Shylaja、金沢晴海、小鹿一、矢島新、額田恭郎、薮田五郎
  • Organizer: 日本農芸化学会年度大会
  • Place of Presentation: 福岡