Development of novel peptide-polymer hybrids for the design of artificial spider silk
| Project/Area Number |
21750130
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Polymer chemistry
|
|---|
| Research Institution | Doshisha University |
|---|
Principal Investigator |
KOGA Tomoyuki 同志社大学, 理工学部, 准教授 (10388043)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | ペプチド / 自己組織化 / スパイダーシルク / ブロックポリマー / 合成高分子 / 高次構造 / β-シート構造 / ネットワーク構造 / β-シート / グラフトポリマー / ナノ構造 |
|---|
| Research Abstract |
Spider silk protein is a self-assembling biopolymer and shows exceptional physical characteristics based on its unique nanostructure. In this study, we designed and synthesized various types of peptide-polymer hybrids such as block-type and graft-type, at which β-sheet-formable oligopeptides were incorporated into conventional synthetic polymers, to create artificial spider silk. These hybrid polymers were found to self-assemble into spider silk-like β-sheet network structure in aqueous media depending on the amino acid sequences of peptide domains and environmental factors. Transparent films were successfully obtained by casting from solutions of these hybrids. The higher order structures and mechanical properties of these films were also examined in detail.
|
Report
(4 results)
Research Products
(93 results)
