| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Structural studies of the proteins that are associated with human accelerated-aging diseases and the proteins that function in the cell signaling pathway, have been performed. Three-dimensional structures of the “RQC domain of Werner syndrome WRN helicase in complex with double-stranded DNA”, “HRDC domain of Bloom syndrome BLM helicase”, and the “heterotrimeric G protein in complex with its specific inhibitor YM-254890” have been determined. These new structures offered insights into the field of biology and medicine.
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