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Study on chromosome de-condensation by analyzing the mechanism of condensin dissociation from mitotic chromosomes

Research Project

Project/Area Number 21770185
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Molecular biology
Research InstitutionOkinawa Institute of Science and Technology (2010)
Kyoto University (2009)

Principal Investigator

NAKAZAWA Norihiko  Okinawa Institute of Science and Technology, 柳田ユニット, 研究員 (70514751)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords染色体分配 / 染色体凝縮 / 細胞周期 / 遺伝子 / ゲノム / 染色体脱凝縮 / コンデンシン複合体 / リン酸化 / オーロラキナーゼ
Research Abstract

Chromosome condensation and segregation are essential phenomena for precise transmission of genome information from mother to daughter cells. In this study, we showed that the condensin complex, which is necessary for chromosome segregation, has continuous role on chromosomes throughout mitosis. Condensin is modified (phosphorylated) during mitosis, but the modification is removed when cells exit from mitosis to next phase (interphase). These results suggest that continuous role of condensin throughout mitosis and its modification changes are important for the stable transmission of genome information and progression of mitotic cells to next cell cycle.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (13 results)

All 2011 2010 2009 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (8 results) Remarks (1 results)

  • [Journal Article] Condensin phosphorylated by the Aurora-B-like kinase Ark1 is continuously required until telophase in a mode distinct from Top,2.2011

    • Author(s)
      Nakazawa N, Mehrotra R, Ebe M, Yanagida M.
    • Journal Title

      Journal of Cell Science 124(11)巻

      Pages: 1795-1807

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fission yeast Pot1 and RecQ helicase are required for efficient chromosome segregation.2011

    • Author(s)
      Takahashi K, Imano R, Kibe T, Seimiya H, Muramatsu Y, Kawabata N, Tanaka G, Matsumoto Y, Hiromoto T, Koizumi Y, Nakazawa N, Yanagida M, Yukawa M, Tsuchiya E, Ueno M.
    • Journal Title

      Molecular and Cellular Biology 31(3)巻

      Pages: 495-506

    • NAID

      120004205356

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Condensin phosphorylated by the Aurora-B-like kinase Ark1 is continuously required until telophase in a mode distinct from Top2.2011

    • Author(s)
      Nakazawa N, Mehrotra R, Ebe M, Yanagida M.
    • Journal Title

      Journal of Cell Science

      Volume: 124(11) Pages: 1795-1807

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fission yeast Pot1 and RecQ helicase are required for efficient chromosome segregation.2011

    • Author(s)
      Takahashi K, Imano R, Kibe T, Seimiya H, Muramatsu Y, Kawabata N, Tanaka G, Matsumoto Y, Hiromoto T, Koizumi Y, Nakazawa N, Yanagida M, Yukawa M, Tsuchiya E, Ueno M.
    • Journal Title

      Molecular and Cellular Biology

      Volume: 31(3) Pages: 495-506

    • NAID

      120004205356

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Phosphorylation of Cnd2/Barren by aurora B-like Ark1 ensures continuous requirement of condensin till telophase in the mode distinct from Top22011

    • Author(s)
      中沢宜彦
    • Organizer
      FEBS Advanced Lecture Course 'Trends in Genetics'
    • Place of Presentation
      アルメニア(エレヴァン)
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Phosphorylation of Cnd2/Barren by aurora B-like Ark1 ensures continuous requirement of condensin till telophase in the mode distinct from Top22010

    • Author(s)
      中沢宜彦
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場他
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Fission yeast condensin and DNA topoisomerase II are required for chromosome segregation EVEN AFTER ENTRY INTO mitosis2009

    • Author(s)
      中沢宜彦
    • Organizer
      The 4^<th> International Workshop on Cell Regulation in Division and Arrest
    • Place of Presentation
      沖縄科学技術研究基盤整備機構シーサイドハウス(沖縄県)
    • Year and Date
      2009-11-29
    • Related Report
      2010 Final Research Report
  • [Presentation] FISSION YEAST CONDENSIN AND DNA TOPOISOMERASE II ARE REQUIRED FOR CHROMOSOME SEGREGATION EVEN AFTER ENTRY INTO MITOSIS2009

    • Author(s)
      中沢宜彦
    • Organizer
      The 4^<th> International Workshop on Cell Regulation in Division and Arrest
    • Place of Presentation
      沖縄科学技術研究基盤整備機構シーサイドハウス(沖縄県)
    • Year and Date
      2009-11-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] Fission yeast condensin and DNA topoisomerase II are required for chromosome segregation EVEN AFTER ENTRY INTO mitosis2009

    • Author(s)
      中沢宜彦
    • Organizer
      国際分裂酵母学会 2009
    • Place of Presentation
      国立オリンピック記念青少年記念センター(東京都)
    • Year and Date
      2009-10-26
    • Related Report
      2010 Final Research Report
  • [Presentation] FISSION YEAST CONDENSIN AND DNA TOPOISOMERASE II ARE REQUIRED FOR CHROMOSOME SEGREGATION EVEN AFTER ENTRY INTO MITOSIS2009

    • Author(s)
      中沢宜彦
    • Organizer
      国際分裂酵母学会 2009
    • Place of Presentation
      国立オリンピック記念青少年記念センター(東京都)
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Fission yeast condensin and DNA topoisomerase II are required for chromosome segregation throughout mitosis2009

    • Author(s)
      中沢宜彦
    • Organizer
      Switzerland-Japan Joint meeting 2009
    • Place of Presentation
      ヴィラール(スイス)
    • Year and Date
      2009-05-14
    • Related Report
      2010 Final Research Report
  • [Presentation] FISSION YEAST CONDENSIN AND DNA TOPOISOMERASE II ARE REQUIRED FOR CHROMOSOME SEGREGATION THROUGHOUT MITOSIS2009

    • Author(s)
      中沢宜彦
    • Organizer
      Switzerland-Japan Joint meeting 2009
    • Place of Presentation
      ヴィラール(スイス)
    • Year and Date
      2009-05-14
    • Related Report
      2009 Annual Research Report
  • [Remarks] 中沢宜彦、京都大学総合博物館・学術映像博2009、トークイベント(生命科学の動き-映像に込められた思いを聞く-)、ゲストスピーカー、2009年9月19日、京都大学総合博物館

    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-10-28  

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