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Functional analysis of actin-binding protein Tropomyosin4 in the spindle formation and orientation

Research Project

Project/Area Number 21770200
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Cell biology
Research InstitutionThe University of Tokyo

Principal Investigator

NISHIZUMI Noriko  東京大学, 医科学研究所, 技術専門職員 (30396882)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords減数分裂 / 紡錘体 / リン酸化 / アクチン / マウス卵 / アクチンフィラメント / トロポミオシン
Research Abstract

The mammalian oocyte is highly polarized because asymmetrical spindle migration to the oocyte cortex ensures extrusion of small polar bodies in the two meiotic divisions. To elucidate the mechanism of maintain this polarity, I analyzed the function of an actin-filament associated protein tropomyosin 4(Tm4). Tm4-depletion by siRNA causes abnormal spindles with diffused poles and polarity of spindles in oocyte. These data indicate that Tm4 plays important roles in spindle orientation and chromosome migration during meiosis.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (17 results)

All 2012 2011 2010 2009

All Presentation (17 results)

  • [Presentation] トロポミオシン4による紡錘体と分裂期細胞表層アクチン構造の制御2012

    • Author(s)
      渡海-西住紀子
    • Organizer
      第29回染色体ワークショップ
    • Place of Presentation
      仙台
    • Year and Date
      2012-01-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Tropomyosin 4, actin binding protein, contributes to the proper spindle orientation during mitosis and meiosis2011

    • Author(s)
      Noriko Tokai-Nishizumi
    • Organizer
      2011 ASCB Annual Meeting (The American Society for Cell Biology)
    • Place of Presentation
      デンバーコンベンションセンターUSA
    • Year and Date
      2011-12-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Tropomyosin 4, Actin binding protein, contributes to the proper spindle orientation during mitosis and meiosis2011

    • Author(s)
      Noriko Tokai-Nishizumi
    • Organizer
      2011 Annual Meeting The American Society for Cell Biology
    • Place of Presentation
      Colorado Convention Center
    • Year and Date
      2011-12-03
    • Related Report
      2011 Final Research Report
  • [Presentation] トロポミオシン4は細胞分裂期表層アクチン構造の安定性と紡錘体極性に寄与する/toropomyosin 4 contributes to the proper spindle orientation and cortical actin organization during mitosis2011

    • Author(s)
      渡海紀子
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      北海道大学
    • Year and Date
      2011-06-29
    • Related Report
      2011 Final Research Report
  • [Presentation] トロポミオシン4は細胞分裂期表層アクチン構造の安定性と紡錘体極性に寄与する/Tropomyosin 4 contributes to the proper spindle orientation and cortical actin organization during mitosis2011

    • Author(s)
      渡海(西住)紀子
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      北海道大学
    • Year and Date
      2011-06-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] アクチン結合蛋白質トロポミオシン4の紡錘体形成過程における機能2011

    • Author(s)
      渡海紀子
    • Organizer
      第28回染色体ワークショップ
    • Place of Presentation
      石川
    • Year and Date
      2011-01-11
    • Related Report
      2011 Final Research Report
  • [Presentation] アクチン結合蛋白質トロポミオシン4の紡錘体形成過程における機能2011

    • Author(s)
      渡海(西住)紀子
    • Organizer
      第28回染色体ワークショップ
    • Place of Presentation
      加賀山代温泉 瑠璃光
    • Year and Date
      2011-01-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Tropomyosin 4 contributes to the proper spindle orientation and cortical actomyosin organization during mitosis2011

    • Author(s)
      渡海紀子
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] Tropomyosin 4 contributes to the proper spindle orientation and cortical actomyosin organization during mitosis2011

    • Author(s)
      渡海(西住)紀子
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Toropomyosin 4, a possible substrate of polo-like kinase 1, contributes to the proper spindle orientation and cortical actin organization during mitosis2010

    • Author(s)
      Noriko Tokai-Nishizumi
    • Organizer
      第16回武田科学振興財団生命科学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2010-12-01
    • Related Report
      2011 Final Research Report
  • [Presentation]2010

    • Author(s)
      渡海-西住紀子
    • Organizer
      Global COE International symposium 2010
    • Place of Presentation
      東京大学
    • Year and Date
      2010-03-05
    • Related Report
      2011 Final Research Report
  • [Presentation] アクチン結合蛋白質トロポミオシン4の紡錘体形成過程における機能2010

    • Author(s)
      渡海(西住)紀子
    • Organizer
      第27回染色体ワークショップ
    • Place of Presentation
      御殿場 時之栖
    • Year and Date
      2010-01-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] アクチン結合蛋白質トロポミオシン4の紡錘体形成過程における機能2010

    • Author(s)
      渡海-西住紀子
    • Organizer
      第27回染色体ワークショップ
    • Place of Presentation
      御殿場
    • Related Report
      2011 Final Research Report
  • [Presentation] Toropomyosin 4, a possible substrate of polo-like kinase 1, contributes to the proper spindle orientation during mitosis2009

    • Author(s)
      Noriko Tokai-Nishizumi
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Toropomyosin 4, a possible substrate of polo-like kinase 1, contributes to the proper spindle orientation during mitosis2009

    • Author(s)
      渡海(西住)紀子
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-12-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] polo-like kinase 1の基質候補トロポミオシン4は細胞分裂過程の紡錘体の位置に寄与している2009

    • Author(s)
      Noriko Tokai-Nishizumi
    • Organizer
      第61回日本細胞生物学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-06-04
    • Related Report
      2011 Final Research Report
  • [Presentation] polo-like kinase 1の基質候補トロポミオシン4は細胞分裂過程の紡錘体の位置に寄与している2009

    • Author(s)
      渡海(西住)紀子
    • Organizer
      第61回日本細胞生物学会大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-06-04
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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