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Molecular mechanism of regulation of mitosis-specific chromosome dynamics

Research Project

Project/Area Number 21770222
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Cell biology
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

KINOSHITA Kazuhisa  独立行政法人理化学研究所, 平野染色体ダイナミクス研究室, 専任研究員 (60447886)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords細胞周期 / 細胞分裂 / 染色体 / リン酸化 / キナーゼ
Research Abstract

Condensin complexes play an essential role in regulation of mitotic chromosome dynamics. We developed an experimental system to express, purify and reconstitute recombinant condensin complexes in vitro. Finally, we have succeeded in reconstituting active, recombinant holo-complexes. Using the recombinant complexes, we elucidated the contributions of the ATPase cycle and the non-SMC subunits to condensin functions.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (5 results)

All 2012 2011 2010

All Journal Article (2 results) Presentation (1 results) Book (2 results)

  • [Journal Article] SMC ATPase :コンデンシンとコヒーシンのコアサブユニット2011

    • Author(s)
      木下和久、平野達也
    • Journal Title

      生体の科学

      Volume: 62巻 Pages: 446-449

    • Related Report
      2011 Final Research Report
  • [Journal Article] SMC ATPase:コンデンシンとコヒーシンのコアサブユニット2011

    • Author(s)
      木下和久、平野達也
    • Journal Title

      生体の科学

      Volume: 62巻 Pages: 446-449

    • Related Report
      2011 Annual Research Report
  • [Presentation] 組換えコンデンシン複合体の再構成と機能解析2012

    • Author(s)
      木下和久
    • Organizer
      第29回染色体ワークショップ
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2012-01-26
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Book] 細胞周期フロンティア(「細胞周期M期におけるコンデンシンの動態とリン酸化による制御機構」の項)2010

    • Author(s)
      木下和久
    • Publisher
      共立出版
    • Related Report
      2011 Final Research Report
  • [Book] 細胞周期フロンティア(分担執筆:「細胞周期M期におけるコンデンシンの動態とリン酸化による制御機構」の項)2010

    • Author(s)
      木下和久
    • Publisher
      共立出版
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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