• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Research on the Albatross protein, a regulator of epithelial cell polarity, with its binding partners and related TPHD proteins

Research Project

Project/Area Number 21770225
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Cell biology
Research InstitutionAichi Cancer Center Research Institute

Principal Investigator

INOKO Akihito  愛知県がんセンター(研究所), 発がん制御研究部, 主任研究員 (30393127)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords上皮分化 / ケラチン / 中心体 / 細胞増殖 / 微小管 / 上皮 / 細胞極性 / 細胞間接着
Research Abstract

Keratins are the components specifically expressed in differentiated epithelial cells. Nevertheless, their contribution to the regulation of the differentiation was still unknown. We identified keratin filament-binding proteins, Albatross and trichoplein, as TPHD (trichohyalin and plectin homology domain) proteins, according to their unique amino acid sequences. In this study, we focused on their relation to cellular phenomenon and the molecular mechanistic insight with the binding partners. The findings raised the possibility that TPHD proteins are "bi-player proteins"which coordinate differentiation and proliferation. By further examinations from other aspects, this study may pave the way for understanding the mechanism of the transition between epithelial differentiation and proliferative state, through keratins and keratin-binding proteins.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (12 results)

All 2011 2010 2009 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (7 results) Remarks (3 results)

  • [Journal Article] Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein.2011

    • Author(s)
      Ibi M*, Zou P*, Inoko A*, Shiromizu T, Matsuyama M, Hayashi Y, Enomoto M, Mori D, Hirotsune S, Kiyono T, Tsukita S, Goto H, Inagaki M.
    • Journal Title

      J Cell Sci. 124

      Pages: 857-864

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein2011

    • Author(s)
      Ibi, et al.
    • Journal Title

      J.Cell Sci.

      Volume: 124 Pages: 857-864

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ケラチン結合蛋白質であるトリコプレインは一次線毛形成を抑制する2010

    • Author(s)
      猪子誠人
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] The keratin-binding protein Albatross regulates polarization of epithelial cells2009

    • Author(s)
      猪子誠人
    • Organizer
      Receptor Program Ad Hoc Seminar
    • Place of Presentation
      Abo Akademi(Finland)
    • Year and Date
      2009-06-15
    • Related Report
      2010 Final Research Report
  • [Presentation] The keratin-binding protein Albatross regulates polarization of epithelial cells2009

    • Author(s)
      猪子誠人
    • Organizer
      Receptor Program Ad Hoc Seminar
    • Place of Presentation
      AAbo Akademi(Finland)
    • Year and Date
      2009-06-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] The keratin-binding protein Albatross regulates polarization of epithelial cells2009

    • Author(s)
      猪子誠人
    • Organizer
      Regulation and Manipulation of Information Flow within Dynamic Protein and Lipid Environments(SFB 645 Workshop Cell Architecture and Cell Signalling)
    • Place of Presentation
      University of Bonn(Germany)
    • Year and Date
      2009-06-12
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] ケラチン結合蛋白質アルバトロスは上皮細胞極性を制御する2009

    • Author(s)
      猪子誠人
    • Organizer
      第61回日本細胞生物学会大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2009-06-02
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] The keratin-binding protein Albatross regulates polarization of epithelial cells2009

    • Author(s)
      猪子誠人
    • Organizer
      The 6th European Conference on Intermediate Filaments (Nanofilaments) in Health and Disease
    • Place of Presentation
      Sarohus (Sweden)
    • Related Report
      2010 Final Research Report
  • [Presentation] The keratin-binding protein Albatross regulates polarization of epithelial cells2009

    • Author(s)
      猪子誠人
    • Organizer
      The 6th European Conference on Intermediate Filaments (Nanofilaments) in Health and Disease
    • Place of Presentation
      Sarohus(Sweden)
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.pref.aichi.jp/cancer-center/400/420/421/421-08.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.pref.aichi.jp/cancer-center/400/420/421/421-08.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.pref.aichi.jp/cancer-center/400/420/421/421-08.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi