Role of PFR cells during digit identity determination.
| Project/Area Number |
21770226
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | Tohoku University |
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Principal Investigator |
SUZUKI Takayuki Tohoku University, 加齢医学研究所, 助教 (40451629)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 指の個性 / 骨 / BMP / PFR / 指間部 / ニワトリ / 分子生物学 / 発生生物学 |
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| Research Abstract |
We found that the cells located distal to the digital lay received positional information from interdigit. These cells get BMP signaling from adjacent interdigit located at the posterior side. I named this region 'PFR'. We found that digit identity is controlled by physical flow in the interdigit, and this conclusion brings us new insight how morphogen gradient works in the embryos. Further, we identified single point mutation in Silkie chicken that causes preaxial polydactyly in the leg. We will publish this data in this May, in press now
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Report
(3 results)
Research Products
(14 results)
