A live-imaging analysis of cell death dynamics and its physiological significance during mouse development
Project/Area Number |
21770229
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Developmental biology
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Research Institution | The University of Tokyo |
Principal Investigator |
YAMAGUCHI Yoshifumi The University of Tokyo, 大学院・薬学系研究科, 助教 (10447443)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 細胞死 / アポトーシス / カスパーゼ / ライブイメージング / 神経発生 / 発生生物学 / 神経管閉鎖 |
Research Abstract |
Cell death is an inevitable event for multicellular organisms, but its dynamics and physiological significance in vivo remain to be elucidated. To reveal the dynamics and physiological significance of apoptosis during the neural tube closure, wherein massive apoptosis occurs, we performed a simultaneous live-imaging analysis them by using a novel transgenic mice expressing a genetically-encoded fluorescent reporter for caspase activation.
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Report
(3 results)
Research Products
(28 results)
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[Presentation] Live-imaging analysis of apoptosis and caspase activation reveals that apoptosis is a facilitator of the neural tube closure.2010
Author(s)
Yamaguchi, Y., Shinotsuka, N., Nonomura, K., Takemoto, K., Miura, M.
Organizer
16^<th> International conference of the International Society of Differentiation.
Place of Presentation
Nara, Japan
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[Presentation] Analyzing the contribution of apoptosis and caspase activation during neural tube closure by using time-lapse imaging.2010
Author(s)
Shinotsuka, N., Yamaguchi, Y., Nonomuts, K., Takemoto, K., Kuida, K., Yoshida, H., Miura, M.
Organizer
The 16th Takeda Science Foundation Symposium on Bioscience
Place of Presentation
東京
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[Presentation] Utilization of the Tol2 transposon system for investigating glial development ; cell-type specific expression of transgene in glia by in utero electroporation.2009
Author(s)
Yoshida, A., Yamaguchi, Y., Nonomura, K., Kawakami, K., Takahashi, Y., Miura, M.
Organizer
第3回神経発生討論会
Place of Presentation
岡崎
Related Report
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[Presentation] Targeted expression of transgene in glial cells by the combination of the Tol2 transposon system and in utero electroporation2009
Author(s)
Yoshida, A., Yamaguchi, Y., Nonomura, K., Kawakami, K., Takahashi, Y., Miura, M.
Organizer
第32回日本神経科学会大会
Place of Presentation
名古屋
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