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Temporal regulation of cortical neural precursor cell fate by polycomb group proteins

Research Project

Project/Area Number 21770231
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Developmental biology
Research InstitutionThe University of Tokyo

Principal Investigator

HIRABAYASHI Yusuke  The University of Tokyo, 分子細胞生物学研究所, 助教 (80447391)

Co-Investigator(Renkei-kenkyūsha) GOTOH Yukiko  東京大学, 分子細胞生物学研究所, 教授 (70252525)
Research Collaborator KOSEKI Haruhiko  理化学研究所, 免疫器官形成研究グループ, グループディレクター (40225446)
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords神経幹細胞 / 大脳皮質発生 / ポリコーム / 多分化能 / エピジェネティクス
Research Abstract

During neocortical development, neural precursor cells (NPCs, or neural stem cells) produce various types of neurons and glial cells in a sequential manner. Although the timing of the fate switch during this sequential process is critical for determining the number of each cell type, the mechanisms are not fully understood. The results obtained in this project show that the polycomb group complex (PcG) restricts the competence of NPCs.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (26 results)

All 2011 2010 2009 2007

All Journal Article (8 results) (of which Peer Reviewed: 6 results) Presentation (18 results)

  • [Journal Article] Epigenetic control of neural precursor cell fate during development.2010

    • Author(s)
      Yusuke Hirabayashi, Yukiko Gotoh
    • Journal Title

      Nature Reviews Neuroscience 11(6)

      Pages: 377-388

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Wnt signaling and its downstream target N-Myc regulate basal progenitors in the developing neocortex2010

    • Author(s)
      Atsushi Kuwahara, Yusuke Hirabayashi, Paul S.Knoepfler, Makoto M.Taketo, Juro Sakai, Tatsuhiko Kodama, Yukiko Gotoh
    • Journal Title

      Development 137

      Pages: 1035-1044

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] ポリコーム複合体による神経系前駆細胞のニューロン分化能制御2010

    • Author(s)
      平林祐介、後藤由季子
    • Journal Title

      実験医学 Vol.28 No.3

    • Related Report
      2010 Final Research Report
  • [Journal Article] Epigenetic control of neural precursor cell fate during development2010

    • Author(s)
      Yusuke Hirabayashi, Yukiko Gotoh
    • Journal Title

      Nature Reviews Neuroscience (掲載確定, 印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wnt signaling and its downstream target N-myc regulate basal progenitors in the developing neocortex2010

    • Author(s)
      Kuwahara A, Hirabayashi Y, Knoepfler PS, Taketo MM, Sakai J, Kodama T, Gotoh Y
    • Journal Title

      Development(Cambridge, England) 137

      Pages: 1035-44

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition.2009

    • Author(s)
      Yusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Takaho A Endo, Tetsuro Toyoda, Jun Shinga, Haruhiko Koseki, Miguel Vidal, Yukiko Gotoh
    • Journal Title

      Neuron 63(5)

      Pages: 600-613

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 大脳皮質においてニューロンの数を決定するメカニズム2009

    • Author(s)
      平林祐介、後藤由季子
    • Journal Title

      細胞工学 Vol.28 No.1

    • Related Report
      2010 Final Research Report
  • [Journal Article] Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition2009

    • Author(s)
      Hirabayashi Y, Suzki N, Tsuboi M, Endo TA, Toyoda T, Shinga J, Koseki H, Vidal M, Gotoh Y
    • Journal Title

      Neuron 63

      Pages: 600-13

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Temporal Regulation of Cortical Neural Precursor Cell Fate by Polycomb Group Proteins2011

    • Author(s)
      Yusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Miguel Vidal, Haruhiko Koseki, Yukiko Gotoh
    • Organizer
      CDB Symposium 2011
    • Place of Presentation
      理化学研究所 発生・再生科学総合研究センター(神戸市)
    • Year and Date
      2011-03-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Temporal regulation of cortical neural precursor cell fate by polycomb group proteins2011

    • Author(s)
      Yusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Miguel Vidal, Haruhiko Koseki, Yukiko Gotoh
    • Organizer
      CDB Symposium
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] Temporal regulation of cortical neural precursor cell fate by polycomb group proteins2010

    • Author(s)
      Yusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Yukiko Gotoh
    • Organizer
      Minisymposium on Developmental Neurobiology
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] ポリコーム群タンパク質による大脳皮質神経系前駆細胞の分化運命制御2010

    • Author(s)
      Yusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Yukiko Gotoh
    • Organizer
      分生研シンポジウム2011
    • Place of Presentation
      東京大学弥生講堂
    • Year and Date
      2010-11-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Temporal regulation of cortical neural precursor cell fate by polycomb group proteins2010

    • Author(s)
      Yusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Yukiko Gotoh
    • Organizer
      The 3rd International Congress on Stem Cells and Tissue Formation
    • Place of Presentation
      Dresden, Germany
    • Year and Date
      2010-07-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Temporal regulation of cortical neural precursor cell fate by polycomb group proteins2010

    • Author(s)
      Yusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Miguel Vidal, Haruhiko Koseki, Yukiko Gotoh
    • Organizer
      Keystone Symposium-Dynamics of Eukaryotic Transcription during Development
    • Place of Presentation
      BIg Sky, USA
    • Year and Date
      2010-04-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Temporal regulation of cortical neural precursor cell fate by polycomb group proteins2010

    • Author(s)
      Yusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Miguel Vidal, Haruhiko Koseki, Yukiko Gotoh
    • Organizer
      Minisymposium on Developmental Neurobiology
    • Place of Presentation
      San Diego, CA
    • Related Report
      2010 Final Research Report
  • [Presentation] ポリコーム群タンパク質による大脳皮質神経系前駆細胞の分化運命制御2010

    • Author(s)
      平林祐介、鈴木菜央、壷井將史、後藤由季子
    • Organizer
      分生研シンポジウム2010(口頭発表)
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] ポリコーム群タンパク質による大脳皮質神経系前駆細胞の分化運命制御2010

    • Author(s)
      平林祐介、鈴木菜央、壷井將史、後藤由季子
    • Organizer
      包括型脳科学研究推進支援ネットワーク夏のワークショップ(ポスター発表)
    • Place of Presentation
      札幌
    • Related Report
      2010 Final Research Report
  • [Presentation] Temporal regulation of cortical neural precursor cell fate by polycomb group proteins2010

    • Author(s)
      Yusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Miguel Vidal, Haruhiko Koseki, Yukiko Gotoh
    • Organizer
      2nd German-Japanese Neurogenesis Meeting 2010
    • Place of Presentation
      Spreewald, Germany
    • Related Report
      2010 Final Research Report
  • [Presentation] Temporal regulation of cortical neural precursor cell fate by polycomb group proteins2009

    • Author(s)
      Yusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Miguel Vidal, Haruhiko Koseki, Yukiko Gotoh
    • Organizer
      EuroEpiStem-2009 Meeting
    • Place of Presentation
      Cambridge, UK
    • Year and Date
      2009-11-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] ポリコーム群タンパク質による大脳皮質神経系前駆細胞の分化運命制御2009

    • Author(s)
      Yusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Miguel Vidal, Haruhiko Koseki, Yukiko Gotoh
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Temporal regulation of cortical neural precursor cell fate by polycomb group proteins2009

    • Author(s)
      Yusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Miguel Vidal, Haruhiko Koseki, Yukiko Gotoh
    • Organizer
      ISSCR 8th Annual Meeting
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2009-07-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Temporal regulation of cortical neural precursor cell fate by polycomb group proteins2009

    • Author(s)
      Yusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Miguel Vidal, Haruhiko Koseki, Yukiko Gotoh
    • Organizer
      EuroEpiStem--2009 Meeting
    • Place of Presentation
      Cambridge, UK
    • Related Report
      2010 Final Research Report
  • [Presentation] ポリコーム群タンパク質による大脳皮質神経系前駆細胞の分化運命制御2009

    • Author(s)
      平林祐介、鈴木菜央、壷井將史、Miguel Vidal, 古関明彦, 後藤由季子
    • Organizer
      第82回日本生化学会大会(口頭発表)
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] Temporal regulation of cortical neural precursor cell fate by polycomb group proteins2009

    • Author(s)
      Yusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Miguel Vidal, Haruhiko Koseki, Yukiko Gotoh
    • Organizer
      ISSCR 8th Annual Meeting
    • Place of Presentation
      (Barcelona, Spain) Poster presentation
    • Related Report
      2010 Final Research Report
  • [Presentation] Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition2009

    • Author(s)
      Yusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Miguel Vidal, Haruhiko Koseki, Yukiko Gotoh
    • Organizer
      Keystone Symposia-Chromatin Dynamics and Higher Order Organization
    • Place of Presentation
      (Coeurd'Alene, ID) Poster presentation
    • Related Report
      2010 Final Research Report
  • [Presentation] Epigenetic modification regulates the termination of Wnt-dependent neurogenesis in the developing mouse neocortex2007

    • Author(s)
      Yusuke Hirabayashi, Tokushige Nakano, Norihisa Masuyama, Yukiko Gotoh
    • Organizer
      ISSCR 8th Annual Meeting
    • Place of Presentation
      (Cairns, Australia) Poster presentation
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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