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Analysis of regulatory mechanisms for Xenopus embryogenesis dependent on the dynamic shape changes of cytoplasmic organelles

Research Project

Project/Area Number 21770236
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Developmental biology
Research InstitutionYamaguchi University

Principal Investigator

UENO Shuichi  山口大学, 大学院・医学系研究科, 助教 (80363092)

Research Collaborator IWAO Yasuhiro  山口大学, 大学院・医学系研究科, 教授 (10144916)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords細胞内小器官 / 細胞周期 / Xenopus / Convergent Extension / P-body / PI3K / PTEN / MBT
Research Abstract

We have found that the cytoplasmic organelles changed dynamically their shape during which the morphogenesis began after cell proliferation at MBT. For example at MBT, the golgi apparatus, which is necessary for protein traffic and modification, was reassembled from its fragments, and the P-body, in which mRNAs degrade efficiently, emerged. We think that these changes were necessary for protein secretion and maternal mRNA degradation after MBT. Otherwise, we showed that the molecular mechanism which triggered the initiation of cell cycle elongation at MBT.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report

Research Products

(17 results)

All 2011 2010 2009 Other

All Journal Article Presentation Remarks

  • [Journal Article] Role of the PI3K-TOR-S6K pathway in the onset of cell cycle elongation during Xenopus early embryogenesis2011

    • Author(s)
      S. Ueno, T. Ueno, Y. Iwao.
    • Journal Title

      Development Growth & Differentiation

      Volume: 53 Pages: 924-933

    • NAID

      10030403909

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Presentation] ツメガエル原腸胚の背側中胚葉における細胞周期制御2011

    • Author(s)
      上野秀一、山口壮太、岩尾康宏
    • Organizer
      第82回日本動物学会
    • Place of Presentation
      旭川・旭川市大雪クリスタルホール
    • Year and Date
      2011-09-21
    • Related Report
      2011 Final Research Report
  • [Presentation] ツメガェル原腸胚の背側中胚葉における細胞周期制御2011

    • Author(s)
      上野秀一、山口壮太、岩尾康宏
    • Organizer
      第82回日本動物学会
    • Place of Presentation
      大雪アリーナ(旭川市)
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cell cycle arrest of mesodermal cells in Xenopus Keller explants2010

    • Author(s)
      上野秀一、山口壮太、岩尾康宏
    • Organizer
      第33回日本分子生物学会
    • Place of Presentation
      神戸・神戸ポートアイランド
    • Year and Date
      2010-12-08
    • Related Report
      2011 Final Research Report
  • [Presentation] Cell cycle arrest of mesodermal cells in Xenopus Kelley explants2010

    • Author(s)
      上野秀一
    • Organizer
      第33回日本分子生物学会
    • Place of Presentation
      神戸・神戸国際展示場
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] A novel role of extra-mitochondiral citrat synthase during Xenopus early embryonicdevelopment2010

    • Author(s)
      桑名貴幸、上野秀一、岩尾康宏
    • Organizer
      第43回日本発生生物学会
    • Place of Presentation
      京都・国立京都国際会館
    • Year and Date
      2010-06-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Imaging of the cell cycle phases in Xenopus Keller explants2010

    • Author(s)
      上野秀一、山口壮太、岩尾康宏
    • Organizer
      第43回日本発生生物学会
    • Place of Presentation
      京都・国立京都国際会館
    • Year and Date
      2010-06-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Imaging of the cell cycle phases in Xenopus Keller explants2010

    • Author(s)
      上野秀一
    • Organizer
      第43回日本発生生物学会
    • Place of Presentation
      京都・京都国際会館
    • Year and Date
      2010-06-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 両生類ツメガエルの初期発生におけるクエン酸合成酵素の役割2009

    • Author(s)
      桑名貴幸、上野秀一、岩尾康宏
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      横浜・パシフィコ横浜
    • Year and Date
      2009-12-11
    • Related Report
      2011 Final Research Report
  • [Presentation] ツメガエル初期胚における細胞周期位相のイメージング2009

    • Author(s)
      山口壮太、上野秀一、岩尾康宏
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      横浜・パシフィコ横浜
    • Year and Date
      2009-12-10
    • Related Report
      2011 Final Research Report
  • [Presentation] ツメガエル初期胚における細胞周期位相のイメージング2009

    • Author(s)
      山口壮太
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      神奈川県・パシフィコ横浜
    • Year and Date
      2009-12-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Beginning and progression of cell cycle elongation after MBT in Xenopus embryos2009

    • Author(s)
      上野秀一、瀧水智代、岩尾康宏
    • Organizer
      第42回日本発生生物学会
    • Place of Presentation
      新潟・朱鷺メッセ
    • Year and Date
      2009-05-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Beginning and progression of cell cycle elongation after MBT in Xenopus embryos2009

    • Author(s)
      上野秀一
    • Organizer
      第42回日本発生生物学会
    • Place of Presentation
      新潟県・朱鷺メッセ
    • Year and Date
      2009-05-30
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等(研究概要・成果公表)

    • URL

      http://ds.cc.yamaguchi-u.ac.jp/.suenoscb/index.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://ds.CC.yamaguchi-u.ac.jp/~suenoscb/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://ds.cc.yamaguchi-u.ac.jp/~suenoscb/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://ds.cc.yamaguchi-u.ac.jp/~suenoscb/index.html

    • Related Report
      2009 Annual Research Report

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Published: 2009-03-31   Modified: 2016-04-21  

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