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Mechanisms of the PCP signal transduction to bend neuroepithelial layer

Research Project

Project/Area Number 21770250
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Developmental biology
Research InstitutionKobe University (2011-2012)
The Institute of Physical and Chemical Research (2009-2010)

Principal Investigator

NISHIMURA Tamako  神戸大学, 自然科学系先端融合研究環・重点研究部 (40415261)

Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥5,284,136 (Direct Cost: ¥4,064,720、Indirect Cost: ¥1,219,416)
Fiscal Year 2012: ¥1,254,136 (Direct Cost: ¥964,720、Indirect Cost: ¥289,416)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords神経管 / 平面内極性 / F-アクチン / ミオシン / neural tube / planar cell polarity / アクトミオシン / 神経上皮細胞
Research Abstract

Neural tube is the precursor of the central nervous system, andformed by the bending of the neural plate along the body axis, although underlying mechanisms were not completely understood. We found that at the apical cell-cell contact sites of the neuroepithelial cells, which constitute neural plate, actomyosin cytoskeleton is activated and contracted in the direction perpendicular to the body axis, leading to a tube formation. Furthermore, we uncovered a novel signaling pathway in which the planar cell polarity signaling regulates the polarized activation of actomyosin in the bending neural plate.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report

Research Products

(9 results)

All 2012 2011 2010 2009

All Journal Article Presentation

  • [Journal Article] Planar cell polarity links axes of spatial dynamics in neural tube closure2012

    • Author(s)
      Tamako Nishimura, Hisao Honda and Masatoshi Takeichi
    • Journal Title

      Cell

      Volume: 149:5 Pages: 1084-1097

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 1. Planar cell polarity links axes of spatial dynamics in neural tube closure.2012

    • Author(s)
      Nishimura, T.
    • Journal Title

      Cell

      Volume: 149 Pages: 1084-1097

    • DOI

      10.1016/j.cell.2012.04.021

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of a centrosomal protein kendrin in the maintenance of centrosome cohesion by modulating Nek2A kinase activity.2010

    • Author(s)
      Kazuhiko Matsuo, et al.
    • Journal Title

      Biochem Biophys Research Communication

      Volume: 398 Pages: 217-223

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Remodeling of the adherens junctions during morphogenesis2009

    • Author(s)
      Tamako Nishimuraand Masatoshi Takeichi
    • Journal Title

      Current Topics in Developmental Biology

      Volume: 89 Pages: 33-54

    • Related Report
      2012 Final Research Report
  • [Journal Article] Remodeling of the adherens junctions during morphogenesis2009

    • Author(s)
      Nishimura T., Takeichi M.
    • Journal Title

      Current Topics in Developmental Biology 89

      Pages: 33-54

    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経管形成に必要なアクトミオシンの極性的収縮は平面内極性分子 Celsr1 によって制御される2012

    • Author(s)
      西村珠子、竹市雅俊
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 神経管形成に必要なアクトミオシンの極性的収縮は平面内極性分子Celsr1によって制御される2012

    • Author(s)
      西村珠子、竹市雅俊
    • Organizer
      第85回日本生化学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] PCP signals regulate neural tube closure through polarized activation of actomyosin cables associated with the adherens junctions.2011

    • Author(s)
      西村珠子、竹市雅俊
    • Organizer
      第44回日本発生生物学会年会
    • Place of Presentation
      沖縄
    • Year and Date
      2011-06-19
    • Related Report
      2012 Final Research Report
  • [Presentation] PCP signals regulate neural tube closure through polarized activation of actomyosin cables associated with the adherens junctions2011

    • Author(s)
      西村珠子、竹市雅俊
    • Organizer
      第44回日本発生生物学会年会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県)
    • Year and Date
      2011-06-19
    • Related Report
      2011 Annual Research Report

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Published: 2009-03-31   Modified: 2019-07-29  

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