Induction mechanism of peripheral nervous system in ascidian
| Project/Area Number |
21770252
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
OHTSUKA Yukio 独立行政法人産業技術総合研究所, バイオメディカル研究部門, 研究員 (90344192)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 進化発生 / ホヤ / 誘導 / nodalシグナル / 転写調節 |
|---|
| Research Abstract |
In order to understand the induction of ascidian peripheral nervous system, I investigated the role of nodal signaling pathway in neural plate border induction. My results show that nodal regulates the specification of ascidian peripheral neurons via induction of chordin and BMPs in neural plate border. In addition, I isolate the cis-regulatory elements of nodal target genes, ci-chordin and ci-Pax3/7, and identify their nodal response elements.
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Report
(4 results)
Research Products
(3 results)
