The association among folate intakes, homocysteine and atherosclerosis.

• Project/Area Number: 21770267
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Applied anthropology
• Research Institution: Nagasaki University
• Principal Investigator: NAKAZATO Mio 長崎大学, 大学院・医歯薬学総合研究科, 助教 (00380973)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 葉酸 / 動脈硬化 / 頸動脈内中膜複合体厚 / 心臓足首血管指数 / ホモシステイン / 離島 / へき地 / 頸動脈内中膜複合体 / 赤血球中葉酸

Research Abstract

This study was investigated the association among homocysteine, folate, methylene-tetrahydrofolate reductase gene C677Tpolymorphism, and clinical evaluations of atherosclerosis on three remote islands with different populations. Although homocysteine reversely correlated to folate, homocysteine or folate were not correlate to clinical evaluations of atherosclerosis. The homocysteine has lower values in island with less population, and it has divergence among homocysteine, serum folate and erythrocyte folate values. They are suggested that homocysteine were affected by environmental factors excluding MTHFR gene polymorphism or folate intake, and erythrocyte folate was better than serum folate as indicator of folate status.

Research Products

• [Journal Article] Lack of an association between E-selectin gene polymorphisms and the risk of Kawasaki disease (2012)
  • Author(s): Shirakawa T, Ikeda K, Nishimura S, Kuniba H, Nakashima K, Motomura H, Mizuno Y, Zaitsu M, Nakazato M, Maeda T, Hamasaki Y, Hara T, Moriuchi H
  • Journal Title: Pediatr Int
• [Journal Article] Blood Folate Concentrations Analyzed by Microbiological Assay and Chemiluminescent Immunoassay Methods (2012)
  • Author(s): Mio Nakazato, Takahiro Maeda, Kosuke Emura, Mayu Maeda, Tsunenobu Tamura
  • Journal Title: J Nutr Sci Vitaminol Volume: (58) Pages: 59-62
• [Journal Article] Relation of body mass index to blood folate and total homocysteine concentrations in Japanese adults (2011)
  • Author(s): Nakazato M, Maeda T, Takamura N, Wada M, Yamasaki H, Johnston KE, Tamura T
  • Journal Title: Eur J Nutr Volume: 50(7) Pages: 581-5
• [Journal Article] The association between atherosclerosis and plasma homocysteine concentration in the general population residing on remote islands in Japan (2011)
  • Author(s): Nakazato M, Takamura N, Kadota K, Yamasaki H, Mukae H, Kusano Y, Nakashima K, Ozono Y, Aoyagi K, Kohno S, Maeda T
  • Journal Title: ACTA MEDICA NAGASAKIENSIA Volume: (55) Pages: 47-54
• [Journal Article] The association between atherosclerosis and plasma homocysteine concentration in the general population residing on remote islands in Japan. (2011)
  • Author(s): Nakazato M, Takamura N, Kadota K, Yamasaki H, Mukae H, Kusano Y, Nakashima K, Ozono Y, Aoyagi K, Kohno S, Maeda T
  • Journal Title: ACTA MEDICA NAGASAKIENSIA Volume: 55 Pages: 47-54
  • Peer Reviewed
• [Journal Article] Relation of body mass index to blood folate and total homocysteine concentrations in Japanese adults. (2011)
  • Author(s): Nakazato M, Maeda T, Takamura N, Wada M, Yamasaki H, Johnston KE, Tamura T
  • Journal Title: Eur J Nutr Volume: Jan 8(Epub 掲載確定)
  • Peer Reviewed
• [Journal Article] Leptin to high-molecular-weight adiponectin ratio is independently correlated with carotid intima-media thickness in men, but not in women (2010)
  • Author(s): Takamura N, Hayashida N, Hagane K, Kadota K, Yamasaki H, Abiru N, Ozono Y, Kamihira S, Aoyagi K, Ishibashi K, Nakazato M, Maeda T
  • Journal Title: Biomarkers Volume: 15(4) Pages: 340-4
• [Journal Article] White blood cell count and cardiovascular biomarkers of atherosclerosis (2010)
  • Author(s): Sekitani Y, Hayashida N, Kadota K, Yamasaki H, Abiru N, Nakazato M, Maeda T, Ozono Y, Takamura N
  • Journal Title: Biomarkers Volume: 15(5) Pages: 454-60
• [Journal Article] White blood cell count and cardiovascular biomarkers of atherosclerosis. (2010)
  • Author(s): Sekitani Y, Hayashida N, Kadota K, Yamasaki H, Abiru N, Nakazato M, Maeda T, Ozono Y, Takamura N
  • Journal Title: Biomarkers Volume: Aug15(5) Pages: 454-60
  • Peer Reviewed
• [Journal Article] Leptin to high-molecular-weight adiponectin ratio is independently correlated with carotid intima-media thickness in men, but not in women. (2010)
  • Author(s): Takamura N, Hayashida N, Hagane K, Kadota K, Yamasaki H, Abiru N, Ozono Y, Kamihira S, Aoyagi K, Ishibashi K, Nakazato M, Maeda T.
  • Journal Title: Biomarkers Volume: Jun15(4) Pages: 340-4
  • Peer Reviewed
• [Journal Article] A validated HPLC-fluorescence method with a semi-micro column for routine determination of homocysteine, cysteine and cysteamine, and the relation between the thiol derivatives in normal human plasma (2009)
  • Author(s): Ichinose S, Nakamura M, Maeda M, Ikeda R, Wada M, Nakazato M, Ohba Y, Takamura N, Maeda T, Aoyagi K, Nakashima K
  • Journal Title: Biomed Chromatogr Volume: 23(9) Pages: 935-9
• [Journal Article] Relationship between periodontal status and HbA1c in nondiabetics (2009)
  • Author(s): Hayashida H, Kawasaki K, Yoshimura A, Kitamura M, Furugen R, Nakazato M, Takamura N, Hara Y, Maeda T, Saito T
  • Journal Title: J Public Health Dent Volume: 69(3) Pages: 204-6
• [Journal Article] Relationship between periodontal status and HbAlc in nondiabetics (2009)
  • Author(s): Hayashida H
  • Journal Title: J Public Health Dent. 69 Pages: 204-206
  • Peer Reviewed
• [Journal Article] A validated HPLC-fluorescence method with a semi-micro column for routine determination of homocysteine, cysteine and cysteamine, and the relation between the thiol derivatives in normal human plasma (2009)
  • Author(s): Ichinose S
  • Journal Title: Biomed Chromatogr. 23 Pages: 935-939
  • Peer Reviewed
• [Presentation] 動脈硬化関連遺伝子の多型解析 (2011)
  • Author(s): 中里未央, 関田孝晴, 高村昇, 青柳潔, 草野洋介, 江村康佑, 前田隆浩
  • Organizer: 日本生理人類学会第64回大会
  • Place of Presentation: 九州大学大橋キャンパス
  • Year and Date: 2011-06-11
• [Presentation] 動脈硬化関連遺伝子の多型解析 (2011)
  • Author(s): 中里未央, 関田孝晴, 高村昇, 青柳潔, 草野洋介, 江村康佑, 前田隆浩
  • Organizer: 日本生理人類学会第64回大会
  • Place of Presentation: 九州大学大橋キャンパス多次元デザイン実験棟
  • Year and Date: 2011-06-11
• [Presentation] 健診受診者3,908名における、内膜中膜複合体厚(IMT)と心臓足首血管指数(CAVI)に影響を与える因子の検討 (2011)
  • Author(s): 中里未央, 関田孝晴, 江村康介, 門田耕一郎, 和田光弘, 前田隆浩, 太田幹也
  • Organizer: 第2回日本病院総合診療医学会学術総会
  • Place of Presentation: 仙台
  • Year and Date: 2011-02-04
• [Presentation] 動脈硬化関連遺伝子の多型解析 (2010)
  • Author(s): 江村康介, 中里未央, 関田孝晴, 小足公彦, 前田隆浩
  • Organizer: 第32回長崎県地域医療研究会
  • Place of Presentation: 長崎
  • Year and Date: 2010-10-30
• [Presentation] ホモシステインと頸動脈内中膜複合体厚(CIMT)及び心臓足首血管指数(CAVI)との関連 (2010)
  • Author(s): 中里未央, 関田孝晴, 門田耕一郎, 高村昇, 中島健一郎, 前田隆浩, 吉谷清光
  • Organizer: 第1回日本プライマリ・ケア連合学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-06-26
• [Presentation] 葉酸測定における微生物測定法(microbiologicalassay)と化学発光酵素免疫測定法(chemiluminescent enzyme immunoassay)の比較 (2010)
  • Author(s): 江村康佑, 中里未央, 関田孝晴, 前田隆浩, Kelly Johnston, 田村庸信, 太田幹也, 小足公彦
  • Organizer: 第59回日本医学検査学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-05-23
• [Presentation] Indices of atherosclerosis in relation to total homocysteine and blood folate levels in Japanese adults (2010)
  • Author(s): M. Nakazato, T. Maeda N. Takamura, K. Kadota, K. Nakashima and T. Tamura
  • Organizer: Experimental Biology 2010
  • Place of Presentation: Anaheim
  • Year and Date: 2010-04-26
• [Presentation] Indices of atherosclerosis in relation to total homocysteine and blood folate levels in Japanese adults. (2010)
  • Author(s): M.Nakazato, T.Maeda N.Takamura, K.Kadota, K.Nakashima, T.Tamura.
  • Organizer: Experimental Biology 2010
  • Place of Presentation: Anaheim
  • Year and Date: 2010-04-26
• [Presentation] 本邦における赤血球中葉酸濃度とホモシステイン、動脈硬化との関連 (2010)
  • Author(s): 中里未央, 前田隆浩, 青柳潔, 高村昇, 門田耕一郎, 大園惠幸, 山崎浩則
  • Organizer: 第1回日本病院総合診療医学会学術総会
  • Place of Presentation: IP HOTEL Fukuoka
  • Year and Date: 2010-02-05
• [Presentation] 葉酸測定における微生物測定法(microbiological assay)と化学発光免疫測定法(chemiluminescent immunoassay)の比較 (2010)
  • Author(s): 中里未央
  • Organizer: 日本病院総合診療医学会
  • Place of Presentation: IP HOTEL Fukuoka
  • Year and Date: 2010-02-05
• [Presentation] 離島住民における赤血球中葉酸とホモシステインとの関連 (2009)
  • Author(s): 中里未央, 草野洋介, 高村昇, 中島憲一郎, 青柳潔, 大園惠幸, 前田隆浩
  • Organizer: 日本生理人類学会第60回大会
  • Place of Presentation: 北海道大学学術交流会館
  • Year and Date: 2009-06-06
• [Presentation] 離島住民における赤血球中葉酸とホモシステインとの関連 (2009)
  • Author(s): 中里未央
  • Organizer: 日本生理人類学会
  • Place of Presentation: 北海道大学学術交流会館
  • Year and Date: 2009-06-06