The association among folate intakes, homocysteine and atherosclerosis.
Project/Area Number |
21770267
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Applied anthropology
|
Research Institution | Nagasaki University |
Principal Investigator |
NAKAZATO Mio 長崎大学, 大学院・医歯薬学総合研究科, 助教 (00380973)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 葉酸 / 動脈硬化 / 頸動脈内中膜複合体厚 / 心臓足首血管指数 / ホモシステイン / 離島 / へき地 / 頸動脈内中膜複合体 / 赤血球中葉酸 |
Research Abstract |
This study was investigated the association among homocysteine, folate, methylene-tetrahydrofolate reductase gene C677Tpolymorphism, and clinical evaluations of atherosclerosis on three remote islands with different populations. Although homocysteine reversely correlated to folate, homocysteine or folate were not correlate to clinical evaluations of atherosclerosis. The homocysteine has lower values in island with less population, and it has divergence among homocysteine, serum folate and erythrocyte folate values. They are suggested that homocysteine were affected by environmental factors excluding MTHFR gene polymorphism or folate intake, and erythrocyte folate was better than serum folate as indicator of folate status.
|
Report
(4 results)
Research Products
(26 results)
-
[Journal Article] Lack of an association between E-selectin gene polymorphisms and the risk of Kawasaki disease2012
Author(s)
Shirakawa T, Ikeda K, Nishimura S, Kuniba H, Nakashima K, Motomura H, Mizuno Y, Zaitsu M, Nakazato M, Maeda T, Hamasaki Y, Hara T, Moriuchi H
-
Journal Title
Related Report
-
-
-
[Journal Article] The association between atherosclerosis and plasma homocysteine concentration in the general population residing on remote islands in Japan2011
Author(s)
Nakazato M, Takamura N, Kadota K, Yamasaki H, Mukae H, Kusano Y, Nakashima K, Ozono Y, Aoyagi K, Kohno S, Maeda T
-
Journal Title
ACTA MEDICA NAGASAKIENSIA
Volume: (55)
Pages: 47-54
Related Report
-
[Journal Article] The association between atherosclerosis and plasma homocysteine concentration in the general population residing on remote islands in Japan.2011
Author(s)
Nakazato M, Takamura N, Kadota K, Yamasaki H, Mukae H, Kusano Y, Nakashima K, Ozono Y, Aoyagi K, Kohno S, Maeda T
-
Journal Title
ACTA MEDICA NAGASAKIENSIA
Volume: 55
Pages: 47-54
Related Report
Peer Reviewed
-
-
[Journal Article] Leptin to high-molecular-weight adiponectin ratio is independently correlated with carotid intima-media thickness in men, but not in women2010
Author(s)
Takamura N, Hayashida N, Hagane K, Kadota K, Yamasaki H, Abiru N, Ozono Y, Kamihira S, Aoyagi K, Ishibashi K, Nakazato M, Maeda T
-
Journal Title
Biomarkers
Volume: 15(4)
Pages: 340-4
Related Report
-
-
-
[Journal Article] Leptin to high-molecular-weight adiponectin ratio is independently correlated with carotid intima-media thickness in men, but not in women.2010
Author(s)
Takamura N, Hayashida N, Hagane K, Kadota K, Yamasaki H, Abiru N, Ozono Y, Kamihira S, Aoyagi K, Ishibashi K, Nakazato M, Maeda T.
-
Journal Title
Biomarkers
Volume: Jun15(4)
Pages: 340-4
Related Report
Peer Reviewed
-
[Journal Article] A validated HPLC-fluorescence method with a semi-micro column for routine determination of homocysteine, cysteine and cysteamine, and the relation between the thiol derivatives in normal human plasma2009
Author(s)
Ichinose S, Nakamura M, Maeda M, Ikeda R, Wada M, Nakazato M, Ohba Y, Takamura N, Maeda T, Aoyagi K, Nakashima K
-
Journal Title
Biomed Chromatogr
Volume: 23(9)
Pages: 935-9
Related Report
-
-
-
-
[Presentation] 動脈硬化関連遺伝子の多型解析2011
Author(s)
中里未央, 関田孝晴, 高村昇, 青柳潔, 草野洋介, 江村康佑, 前田隆浩
Organizer
日本生理人類学会第64回大会
Place of Presentation
九州大学大橋キャンパス
Year and Date
2011-06-11
Related Report
-
[Presentation] 動脈硬化関連遺伝子の多型解析2011
Author(s)
中里未央, 関田孝晴, 高村昇, 青柳潔, 草野洋介, 江村康佑, 前田隆浩
Organizer
日本生理人類学会第64回大会
Place of Presentation
九州大学大橋キャンパス多次元デザイン実験棟
Year and Date
2011-06-11
Related Report
-
-
-
-
-
-
-
-
-
-