| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
This study is aimed at construction of recombinant methylotrophic bacteria to produce flexible polyhydroxyalkanoate(PHA) copolymers from methanol using Methylobacterium extorquens AM1 as a host strain. The results revealed that M. extorquens wild-type strain accumulates PHA copolymer composed of mostly C4 monomer with a small amount of C_5 unit. The recombinant strains, which can accumulate PHA composed of C_4, C_5, and C_6 unit, was successfully obtained. These strains produced PHA more efficiently than wild-type strain.
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