| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
We studied on the molecular mechanisms underlying the development of hormone therapy-resistant prostate cancer. The C-teminal truncated form of androgen receptor (AR) was produced when prostate cancer cells were incubated in the absence of ligand or in the presence of androgen antagonist. It was expected that the short form of AR acts as transcription factor in a ligand-independent manner. Resveratol inhibited DNA binding of AR, presumably by decreasing its level of acetylation. In addition, it was speculated that resveratrol inhibits the transcriptional activity of the short form of AR.
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