| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
We demonstrated that (1) bovine oocytes and preimplantation embryos express methylation pathway enzymes ; (2) among the metabolites in methylation pathway, homocysteine affects the level of DNA methylation, and methionine, thorough its conversion to S-adenosylmethionine, is involved in morula-to-blastocyst transition during bovine preimplantation development. The existence and importance of methylation pathway in bovine preimplantation development were suggested.
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