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Pathogenesis of rabies virus in neuronal cells

Research Project

Project/Area Number 21780271
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Applied veterinary science
Research InstitutionHokkaido University

Principal Investigator

SUNDEN Yuji  Hokkaido University, 大学院・獣医学研究科, 助教 (20451403)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords狂犬病 / 中和抗体 / 病原性 / 神経細胞 / ウイルス / 人獣共通感染 / 病原生 / 人獣共通感染症 / Nucleoprotein
Research Abstract

Rabies is a lethal zoonotic disease and its causative agent is rabies virus, which infects in neurons. In the present study, experimental studies using laboratory animals and cultured cells were performed to clarify following two questions ; which viral factors induce dysfunction of neurons? And which immune response is important for the virus clearance from central nervous system (CNS)? By experimental intracerebral vaccination, it was clearly shown that virus-specific antibodies were highly induced in CNS and may contribute to the virus neutralization. Further, virus nucleoprotein interacted with some transcripts of neuronal cells suggesting the interference of host gene expression which may have roles in the pathogenesis of rabies.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (14 results)

All 2011 2010 2009

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (5 results)

  • [Journal Article] The human polyoma JC virus agnoprotein acts as a viroporin.2010

    • Author(s)
      Suzuki T, Orba Y, Okada Y, Sunden Y, Kimura T, Tanaka S, Nagashima K, Hall WW, Sawa H.
    • Journal Title

      PLoS Pathog. 6(3)

    • NAID

      120002128723

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lipopolysaccharide treatment and inoculation of influenza A virus results in influenza virus-associated encephalopathy-like changes in neonatal mice.2010

    • Author(s)
      Tanaka T, Sunden Y, Sakoda Y, Kida H, Ochiai K, Umemura T.
    • Journal Title

      J Neurovirol. 16(2)

      Pages: 125-132

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Natalizumab has no direct biological effect on JC virus infectivity in permissive human neural cell lines.2010

    • Author(s)
      Suzuki T, Yamanouchi S, Sunden Y, Orba Y, Kimura T, Sawa H.
    • Journal Title

      J Med Virol. 82(7)

      Pages: 1229-1235

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular cloning and expression analysis of bovine programmed death-1.2010

    • Author(s)
      Ikebuchi R, Konnai S, Sunden Y, Onuma M, Ohashi K.
    • Journal Title

      Microbiol Immunol. 54(5)

      Pages: 291-298

    • NAID

      10029544893

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intracerebral vaccination suppresses the spread of Rabies virus in the mouse brain.2010

    • Author(s)
      Sunden Y, Yano S, Ishida S, Ochiai K, Umemura T.
    • Journal Title

      Microbes Infect. 12(14-15)

      Pages: 1163-1169

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intracerebral vaccination suppresses the spread of Rabies virus in the mouse brain.2010

    • Author(s)
      Yuji Sunden
    • Journal Title

      Microbes and Infection

      Volume: 12(14-15) Pages: 1163-1169

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lipopolysaccharide treatment and inoculation of influenza A virus results in influenza virus-associated encephalopathy-like changes in neonatal mice.2010

    • Author(s)
      Tomobisa Tanaka
    • Journal Title

      Journal of Neurovirology

      Volume: 16(2) Pages: 125-132

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Natalizumab has no direct biological effect on JC virus infectivity in permissive human neural cell lines.2010

    • Author(s)
      Tadaki Suzuki
    • Journal Title

      Journal of Medical Virology

      Volume: 82(7) Pages: 1229-1235

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro propagation of rabies virus in mouse dorsal root ganglia cells2009

    • Author(s)
      Yoko Hara, Yuji Sunden, et al.
    • Journal Title

      Japanese Journal of Veterinary Research 56(4)

      Pages: 181-188

    • NAID

      120001152961

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 鞘内免疫による脳内への抗体誘導と発症予防効果に関する実験的研究2011

    • Author(s)
      寸田祐嗣、青島圭祐、石田幸代、梅村孝司
    • Organizer
      第10回狂犬病研究会
    • Place of Presentation
      ホテル由布院倶楽部(大分県)
    • Year and Date
      2011-03-04
    • Related Report
      2010 Final Research Report
  • [Presentation] 鞘内免疫による脳内への抗体誘導と発症予防効果に関する実験的研究2011

    • Author(s)
      寸田祐嗣
    • Organizer
      第10回狂犬病研究会
    • Place of Presentation
      大分県由布市
    • Year and Date
      2011-03-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Intracerebral vaccination against PRV showed efficient protection by inducing antibody secreting cells in CNS and lymphoid organs in mouse.2010

    • Author(s)
      李賢敬、寸田祐嗣、梅村孝司
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島県郷土文化会館
    • Related Report
      2010 Final Research Report
  • [Presentation] The role of cyclooxygenase-2 (COX-2) in suckling mice infected with H3N2 subtype influenza virus.2010

    • Author(s)
      Yuji Sunden, Saki Akita, Tomohisa Tanaka, Takashi Umemura.
    • Organizer
      The 2^<nd> Inernational Young Reseacher Seminar in Zoonosis Control
    • Place of Presentation
      Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
    • Related Report
      2010 Final Research Report
  • [Presentation] Suppression of rabies virus propagation in mice brain by intracerebral immunization of inactivated virus2009

    • Author(s)
      Yuji Sunden
    • Organizer
      The 1^<st> International Young Researcher Seminar in Zoonosis Control 2009
    • Place of Presentation
      ホテルニセコいこいの村(北海道、虻田郡ニセコ町)
    • Year and Date
      2009-08-20
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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