Synthetic Studies on Tryprostatins for the Development of Versatile Analogs
| Project/Area Number |
21790009
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SHIMOKAWA Jun The University of Tokyo, 大学院・薬学系研究科, 助教 (60431889)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 合成化学 / 生理活性物質の全合成 / ラジカル反応 / トリプロスタチン / 天然物全合成 / 天然物合成 |
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| Research Abstract |
Establishment of the reliable conditions for the radical-mediated indole construction has made it possible to achieve the highly efficient synthesis of tryprostatins A and B. Lowering the reaction temperature by means of V-70, a radical initiator, suppressed the radical rearrangement to give the desired indoles as the major products.
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Report
(3 results)
Research Products
(15 results)
