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Synthetic study of GKK1032s, directed toward the development of new anticancer drugs

Research Project

Project/Area Number 21790022
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Chemical pharmacy
Research InstitutionTokyo University of Pharmacy and Life Science (2010-2011)
Tohoku Pharmaceutical University (2009)

Principal Investigator

ABE Hideki  東京薬科大学, 生命科学部, 准教授 (00328551)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsGKK1032類 / 不斉合成 / 分子内Diels-Alder反応 / 合成化学 / 多環性アルカロイド / 抗腫瘍性 / 有機化学 / 薬学 / 抗腫瘍活性
Research Abstract

Stereoselective synthesis of the tricyclic decahydrofluorene core(ABC-ring system) of GKK1032s has been accomplished. All attempt for the construction of 13-membered ring of the target compounds(intramolecular Mitsunobu reaction, intramolecular Reformatsky reaction, intramolecular Still coupling reaction, ring closing metathesis, and intramolecular Friedel. Crafts reaction) was failed.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (2 results)

All 2010 2009

All Presentation (2 results)

  • [Presentation] 抗腫瘍活性物質GKK1032類の合成研究2010

    • Author(s)
      菊地拓也、阿部秀樹、渡邉一弘、加藤正
    • Organizer
      第21回万有仙台シンポジウム
    • Place of Presentation
      仙台国際センター(宮城県)
    • Year and Date
      2010-06-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 抗腫瘍活性物質GKK1032類の合成研究2009

    • Author(s)
      菊地拓也、阿部秀樹、渡邉一弘、加藤正
    • Organizer
      第48回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Year and Date
      2009-10-18
    • Related Report
      2011 Final Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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